Formation, Physicochemical Stability, and Redispersibility of Curcumin-Loaded Rhamnolipid Nanoparticles Using the pH-Driven Method

Abstract

The aim of the present work was to fabricate the curcumin-loaded rhamnolipid nanoparticles using the pH-driven method to enhance the physicochemical stability and redispersibility of curcumin. The mixture of curcumin and rhamnolipid could be spontaneously assembled into the curcumin-loaded rhamnolipid nanoparticles with a small size (107 nm) and negative charge (−45.5 mV). Curcumin molecules could bind to rhamnolipid molecules through hydrophobic effects and hydrogen bonds. The effect of different mass ratios of rhamnolipid and curcumin (1:2, 1:1, 2:1, 4:1, 6:1, and 8:1) on the functional property of the curcumin-loaded rhamnolipid nanoparticles was investigated. With the rise of rhamnolipid and curcumin mass ratio, the encapsulation efficiency of curcumin in the nanoparticles was increased from 44.59% to 81.12% and the loading capacity of curcumin was elevated from 10.14% to 31.67%. When the mass ratio of rhamnolipid and curcumin was 4:1, the curcumin-loaded rhamnolipid nanoparticles exhibited better physical stability, pH stability, and redispersibility. Moreover, the nanoparticles could effectively protect curcumin against the photodegradation and thermal degradation. Therefore, the rhamnolipid nanoparticles have the potential to be applied as a nanodelivery system for bioactive molecules in functional foods.

Fabrication and Characterization of Quercetagetin-Loaded Nanoparticles Based on Shellac and Quaternized Chitosan: Improvement of Encapsulation Efficiency and Acid and Storage Stabilities

“…When quercetagetin was combined with shellac and QCS, no sharp peak was detected, indicating that quercetagetin was successfully encapsulated into the nanoparticles, which was consistent with the FTIR. Besides, similar results were also presented by Ma et al and Liang et al, who found that curcumin lost its crystallinity and was transferred into the amorphous state after being embedded inside nanoparticles.…”

Photo-Sono Interfacial Engineering Exciting the Intrinsic Property of Herbal Nanomedicine for Rapid Broad-Spectrum Bacteria Killing

“…The peak at 1500 cm –1 corresponded to the stretching vibration of conjugated carbonyl (CO). The peaks at 1256 and 1155 cm –1 were related to the C–O stretching vibration . The decreased intensity of these peaks compared to the corresponding one obtained from pure Cur may be ascribed to the interaction of CuS and lower content of Cur in the hybrid.…”

Encapsulation of Hydrophobic and Low-Soluble Polyphenols into Nanoliposomes by pH-Driven Method: Naringenin and Naringin as Model Compounds

“…Subsequently, a series of studies on the colloidal delivery systems based on the pH-driven method began to emerge, especially for curcumin encapsulation. The successful preparation of a series of colloidal carrier systems loaded with curcumin enhanced its water solubility and bioavailability, which proved the feasibility of preparing the delivery system with the pH-driven method [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ]. However, the pH-driven method has rarely been applied for the encapsulation of other hydrophobic polyphenols.…”