FORMULATION AND CHARECTERISATION OF COLON TARGETED pH DEPENDENT MICROSPHERES OF CAPECITABINE FOR COLORECTAL CANCER

Agarwal, Deepti; Ranawat, Mahendra Singh; Chauhan, Chetan Singh; Kamble, Ravindra

doi:10.22270/jddt.v3i6.747

Cited by 8 publications

(6 citation statements)

References 23 publications

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“…Microspheres were obtained, filtered, washed with distilled water, air-dried at room temperature and stored in desiccators. [20][21][22][23][24][25][26][27] Formulation Design…”

Section: Methodsmentioning

confidence: 99%

Formulation and Characterization of Microspheres of Nitazoxanide by Chemical Crosslinking Method

Sachan¹,

Gupta²,

Ansari³

2018

J. Drug Delivery Ther.

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The work investigated the design and evaluation of microspheres of Nitazoxanide by Ionotropic gelation technique met. 32 Factorial designs were used and concentration of polymer carbopol-934 (X1) and Ethyl cellulose (X2) were selected as the independent variables. The surface morphology study by SEM indicated that microspheres were spherical with smooth surface. There was no interaction between the drug and polymers, as studied by FTIR study. The prepared microspheres were characterized by entrapment efficiency, particle size micromeritic properties. It was observed that on increasing polymer concentration of formulations, % yield, the entrapment efficiency and particle size were increased whereas % drug release decreased. The In Vitro release study was done using U.S.P. dissolution rate basket type apparatus in phosphate buffer pH 7.4 for 10 hr. It shows that on increasing polymer concentration the drug release of all formulations was gradually decreased. In Vitro mucoadhesion study depicts that as the polymer concentration increased, mucoadhesive nature of the formulation was also increased. The microspheres of NTZ (formulation F9) showed best results due to highest drug entrapment efficiency (85.50%), and percentage drug release after 10.0 hr. was 50.25%. The rate of release followed First order kinetics. The microspheres exhibits good mucoadhesive properties in in- vitro wash-off test at pH 7.4 (Intestinal pH) than pH 1.2 (gastric pH),because the drug was completely absorbed in Gastrointestinal tract, Therefore, it can be concluded that Nitazoxanide Loaded algino-carbopol-934 microspheres can be formulated for sustained drug delivery of Nitazoxanide used in Chronic Hipatitis-C. Keywords: Mucoadhesive microspheres, Nitazoxanide, Carbopol-934, Ethyl cellulose, Sodium Alginate, Factorial design.

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“…Microspheres were obtained, filtered, washed with distilled water, air-dried at room temperature and stored in desiccators. [20][21][22][23][24][25][26][27] Formulation Design…”

Section: Methodsmentioning

confidence: 99%

Formulation and Characterization of Microspheres of Nitazoxanide by Chemical Crosslinking Method

Sachan¹,

Gupta²,

Ansari³

2018

J. Drug Delivery Ther.

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“…Surgery, chemotherapy, and radiotherapy are all cancer treatments. If identified early enough, certain tumours can be treated (8) .…”

Section: Advantages Of Herbal Drugs Over Allopathic Drugsmentioning

confidence: 99%

Medicinal Plant Used Against Cancer: A Review

Srivastava¹,

Tiwari

2022

Asian J Pharm Res Dev

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Nowadays natural products are considered protective markers compared to synthetic products that are considered unsafe for human health and the environment. Although a large number of synthetic drugs have been added to the world of current pharmacopoeia, there is still no drug system in the world that has been able to solve all health problems, including diseases such as Cancer. The extracts from plants have played an important role in the development of clinically effective anti-cancer agents. The plant kingdom produces naturally occurring secondary metabolites that are being investigated for their anti-cancer activities leading to the development of new clinical drugs. Global results continue to identify new anticancer compounds from plants. In recent years out of fear of adverse effects, people have chosen to make greater use of natural cancer products. This review attempted to summarize a few plants in India and outside India that have anti-cancer activity.

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“…Shi et al [7] studied about pH-sensitive and colon-targeting P(LE-IA-MEG) hydrogel microspheres used for ulcerative colitis therapy and demonstrated desirable colon targeting property from The pharmacokinetic studies. Agrawal et al [8] Formulated separately colon targeted pH pendent microspheres using pHsensitive polymer Eudragit L100, S100 of capecitabine for colorectal cancer to reduce dosing frequency and improve patient compliance.…”

Section: Nanoparticles/ Microparticles/microspheresmentioning

confidence: 99%

Colon Targeting Using pH Sensitive Materials

Jain¹

2018

ARGH

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The oral route is the preferred route for drug delivery, among oral delivery Intestine and colon drug delivery have been used for molecules aimed at local treatment of colonic diseases such as Colon Cancer, Polyp, Colorectal, Crohn's Disease, Inflammatory Bowel Disease (IBD), Ulcerative Colitis (UC) etc. and for delivery of molecules susceptible to enzymatic degradation such as peptides. There are various methods have been reported for colon targeting, among them use of pH sensitive polymers for coating and formulation of drug delivery system is most beneficial. The formulations of pH sensitive nanoparticles, hydrogel, microspheres, Polymeric Micelles are commonly reported for colon targeting. This review focuses on advancements of pH sensitive drug delivery system for colon targeting.

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FORMULATION AND CHARECTERISATION OF COLON TARGETED pH DEPENDENT MICROSPHERES OF CAPECITABINE FOR COLORECTAL CANCER

Cited by 8 publications

References 23 publications

Formulation and Characterization of Microspheres of Nitazoxanide by Chemical Crosslinking Method

Formulation and Characterization of Microspheres of Nitazoxanide by Chemical Crosslinking Method

Medicinal Plant Used Against Cancer: A Review

Colon Targeting Using pH Sensitive Materials

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