Fully Integrated Biochip Platforms for Advanced Healthcare

Carrara, Sandro; Ghoreishizadeh, Sara S.; Olivo, Jacopo; Taurino, Irene; Baj-Rossi, Camilla; Cavallini, Alberto; Beeck, Maaike Op de; Dehollain, Catherine; Burleson, Wayne; Moussy, Francis; Guiseppi‐Elie, Anthony; Micheli, Giovanni De

doi:10.3390/s120811013

Cited by 70 publications

(32 citation statements)

References 251 publications

(313 reference statements)

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“…Novel detection platforms have the potential to develop robust, multiplexed ultrasensitive protein detection devices with high efficiency, high data quality, and cost-effectiveness for the identification of pathogens and disease biomarkers in both well-equipped and/or limited clinical facilities [84].…”

Section: Parasite Testing: Biosensor Based Platformsmentioning

confidence: 99%

Sensing parasites: Proteomic and advanced bio-detection alternatives

Sánchez-Ovejero

Benito‐Lopez

Díez

et al. 2016

Journal of Proteomics

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Journal of Proteomics 136 : 145-156 (2016) This work is made available online in accordance with publisher policies. To see the final version of this work please visit the publisher's website. Access to the published online version may require a subscription. This review provides the most recent methodological and technological advances with great potential for bio-sensing parasites in their hosts, showing the newest opportunities offered by modern "-omics" and platforms for parasite detection and control. Link to publisher's version

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Section: Parasite Testing: Biosensor Based Platformsmentioning

confidence: 99%

Sensing parasites: Proteomic and advanced bio-detection alternatives

Sánchez-Ovejero

Benito‐Lopez

Díez

et al. 2016

Journal of Proteomics

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“…Thanks to sharing some of the main blocks among different circuits, the power consumption of the IC is limited to 711 µW from 1.8 V supply voltage, and its area is 1.5 mm × 3.2 mm, making it suitable for implantable applications [15].…”

Section: Temperature Measurementmentioning

confidence: 99%

A configurable IC to contol, readout, and calibrate an array of biosensors

Ghoreishizadeh

Carrara

Micheli

2013

2013 European Conference on Circuit Theory and Design (ECCTD)

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Abstract-We present a novel integrated circuit for a biosensing data acquisition chain. The circuit controls and reads out five bimolecular sensors as well as pH and temperature sensors for biosensor calibration. The IC supports both chronoamperometry (CA) and cyclic voltammetry (CV) measurements, which are commonly used in biosensing. Different voltage waveforms are generated to control CV by using a single configurable waveform generator and programmable constant voltage levels are produced to enable CA. To reduce the area and power consumption of the interface electronics, a unified circuit is designed for CV, CA and pH readout. The biosensors produce currents that are converted by a 13.5-bit sigma delta analog to digital converter. The circuit has been designed and realized in 0.18 µm technology. It consumes 711 µW from a 1.8 V supply voltage, making it suitable for remotely powered and implantable applications.

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“…6,7 These fabrication methods generate portable, compact devices in which the transducers are directly integrated with the circuitry. 8,9 However, although microchips containing electrochemical transducers can be mass-produced, the manufacturing cost of these devices is still too high for certain applications in which the sensor cannot be reutilised or recycled. Electrical readers are also expensive, and therefore their utilisation can only be justified in routine tests, for example in diagnostic tests required by chronic patients (e.g.…”

Section: Introductionmentioning

confidence: 99%

Solution-based nanosensors for in-field detection with the naked eye

Paterson

Rica

2015

Analyst

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This version is available at https://strathprints.strath.ac.uk/52490/ Strathprints is designed to allow users to access the research output of the University of Strathclyde. Unless otherwise explicitly stated on the manuscript, Copyright © and Moral Rights for the papers on this site are retained by the individual authors and/or other copyright owners. Please check the manuscript for details of any other licences that may have been applied. You may not engage in further distribution of the material for any profitmaking activities or any commercial gain. You may freely distribute both the url (https://strathprints.strath.ac.uk/) and the content of this paper for research or private study, educational, or not-for-profit purposes without prior permission or charge.Any correspondence concerning this service should be sent to the Strathprints administrator: strathprints@strath.ac.ukThe Strathprints institutional repository (https://strathprints.strath.ac.uk) is a digital archive of University of Strathclyde research outputs. It has been developed to disseminate open access research outputs, expose data about those outputs, and enable the management and persistent access to Strathclyde's intellectual output.Journal Name Nanomaterials are revolutionising analytical applications with low-cost tests that enable detecting a target molecule in a few steps and with the naked eye. With this approach, nonexperts can perform analyses on-site and without utilising electronic readers. This is advantageous in point-of-care diagnostics, in-field measurements and analyses performed in resource-constrained settings. Here we review the main strategies adopted for detecting analytes with the naked eye and at the point of need using plasmonic nanosensors, catalytic nanoparticles and fluorescent nanomaterials. Examples of the detection of ions, glucose, small molecules, peptides and proteins with the nanosensors are explained in detail. IntroductionThe design of sensors for in-field measurements has been a central issue of analytical chemistry for decades. From the diagnosis of diseases at the point of care 1 to the detection of hazardous levels of pollutants 2,3 and the identification of pathogens in food samples, 4,5 there is a growing need for obtaining accurate information about the composition of a sample rapidly and at the point of need. For many years electrochemical sensors have dominated the area of in-field sensing due to the possibility of fabricating all the elements of the sensor with well-known microfabrication techniques. 6,7 These fabrication methods generate portable, compact devices in which the transducers are directly integrated with the circuitry. 8,9 However, although microchips containing electrochemical transducers can be mass-produced, the manufacturing cost of these devices is still too high for certain applications in which the sensor cannot be reutilised or recycled. Electrical readers are also expensive, and therefore their utilisation can only be justified in routine tests, for example in diagnostic tests r...

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Fully Integrated Biochip Platforms for Advanced Healthcare

Cited by 70 publications

References 251 publications

Sensing parasites: Proteomic and advanced bio-detection alternatives

Sensing parasites: Proteomic and advanced bio-detection alternatives

A configurable IC to contol, readout, and calibrate an array of biosensors

Solution-based nanosensors for in-field detection with the naked eye

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