Functional Drink Containing the Extracts of Purple Corn Cob and Pandan Leaves, the Novel Cognitive Enhancer, Increases Spatial Memory and Hippocampal Neuron Density Through the Improvement of Extracellular Signal Regulated Protein Kinase Expression, Cholinergic Function, and Oxidative Status in Ovariectomized Rats

Kirisattayakul, Woranan; Suriharn, Bhalang; Lertrat, Kamol

doi:10.1089/rej.2017.2009

Cited by 10 publications

(7 citation statements)

References 33 publications

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“…In addition, 1 mg/ml cob extract was able to activate GR activity. These results agreed with those of a previous study in which in vivo antioxidant activity played a critical role in ameliorating diseases, such as diabetes, Opisthorchis viverrini infection and diabetic cataract [14,40,41] .…”

Section: Resultssupporting

confidence: 92%

Protective Effects of Purple Waxy Corn on Aflatoxin B1-induced Oxidative Stress and Micronucleus in HepG2 Cells

Singto¹,

Tassaneeyakul²,

Porasuphatana³

2020

Indian J Pharm Sci

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The purpose of this study was to investigate the protective effects of purple waxy corn extract (Zea may L.) on aflatoxin B1-induced cytotoxicity, oxidative stress and micronuclei in HepG2 cells. Purple waxy corn extract contained phenolics (187.15-341.65 µg gallic acid/mg), flavonoids (0.55-21.35 µg quercetin/ mg) and anthocyanins (43.70-220.43 mg cyanidin-3-glucoside/l). Antioxidant activities of the extracts were measured using oxygen radical absorbance capacity (1410.70-2214.49 µM trolox/mg) and ferric reducing/ antioxidant power (292.38-612.38 µM trolox/mg) assays. There were significant correlations between phenolic, flavonoid and anthocyanin content and antioxidant activities (R=0.740-0.778) of purple waxy corn extract. Studies in HepG2 cells found that 0.5 and 1 mg/ml purple waxy corn extract increased cell viability in AFB1-treated HepG2 cells. Purple waxy corn extract reduced intracellular ROS production, increased GSH content and antioxidant enzyme GR, GPx and GST activities and micronucleus in aflatoxin B1-treated HepG2 cells. Therefore, purple waxy corn extract reduced aflatoxin B1 toxicity through induction of antioxidant activities and, thus, inhibited oxidative stress-induced DNA damage caused by aflatoxin B1s.

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Section: Resultssupporting

confidence: 92%

Protective Effects of Purple Waxy Corn on Aflatoxin B1-induced Oxidative Stress and Micronucleus in HepG2 Cells

Singto¹,

Tassaneeyakul²,

Porasuphatana³

2020

Indian J Pharm Sci

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“…It has been shown that anthocyanin-rich substance can protect against brain damage induced by oxidative stress [12, 50–54]. Therefore, the anthocyanin content in the combined extract of O. sativa and A. graveolens may contribute the role on the improvement of brain infarction and dysfunction observed in this study.…”

Section: Discussionmentioning

confidence: 54%

Cerebroprotective Effect against Cerebral Ischemia of the Combined Extract ofOryza sativaandAnethum graveolensin Metabolic Syndrome Rats

Ohnon

Thukham-mee

Muchmapura

et al. 2019

Oxidative Medicine and Cellular Longevity

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The novel strategy against ischemic stroke in metabolic syndrome (MetS) targeting at oxidative stress and inflammation has gained attention due to the limitation of the current therapy. Due to the antioxidant and anti-inflammation of the combined extract of Oryza sativa and Anethum graveolens, the cerebroprotective effect against cerebral ischemia in MetS condition has been focused. Since no data were available, this study was set up to determine the effects of the combined extract of Oryza sativa L. and Anethum graveolens Linn. against ischemic stroke in the animal model of metabolic syndrome. The possible underlying mechanism was also further investigated. Male Wistar rats (180-220 g) were fed with high-carbohydrate high-fat diet (HCHF diet) to induce metabolic syndrome-like condition. Then, MetS rats were subjected to reperfusion injury at the right middle cerebral artery. The combined extract of O. sativa and A. graveolens (OA extract) at doses of 0.5, 5, and 50 mg/kg BW was fed once daily for 21 days. Neurological assessment was performed every 7 days throughout the experimental period. At the end of study, brain infarction volume, neuron and glial fibrillary acidic protein- (GFAP-) positive cell density, the oxidative stress status, the expressions of proinflammatory cytokines (NF-κB, IL-6), and eNOS in the cortical area together with the expression of VCAM-1 and the histological changes of common carotid artery were determined. It was found that OA extract decreased brain infarction, neurological score, oxidative stress status, and inflammatory mediators but increased eNOS expression in the cortical area; the increased VCAM-1 and intima-media thickness together with the reduction of lumen diameter of common carotid artery of MetS eats with MCAO were also mitigated by OA extract. These data suggest the cerebroprotective effect of OA, and the underlying mechanism may occur partly via the improvement of oxidative stress status, inflammation, and brain blood supply.

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“…MAO activity was measured according to the protocol described previously [ 53 ]. An aliquot of brain homogenate at a volume of 50 μL was incubated with a mixture of 50 μL of chromogenic solution, and 200 μL of 500 μM of tyramine for 30 min at room temperature.…”

Section: Methodsmentioning

confidence: 99%

Anxiety, Insomnia, and Memory Impairment in Metabolic Syndrome Rats Are Alleviated by the Novel Functional Ingredients from Anacardium occidentale

2022

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Despite an increase in the coexistence of metabolic syndrome (MetS) and psychological disorders, together with their great impact on socio-economic burdens, no protective strategies that focus on these situations are available. Due to the role of oxidative stress in the pathophysiology of metabolic syndrome (MetS) and psychological disorders, we hypothesized that substances possessing antioxidant activity such as the novel functional ingredients from Anacardium occidentale (AO) could mitigate common psychological disorders in MetS rats. Male Wistar rats, weighing 200–250 g, were induced with MetS through a 12-week high-fat and high-cholesterol diet (HFHC). Then, they were given AO orally via a gastric gavage needle at doses of 1, 10 and 100 mg/kg BW for 14 days. Spatial memory, anxiety, depression, and sleep behaviors, together with changes in oxidative stress status and neurotransmitters, were assessed. All doses of AO significantly improved memory, anxiety, and sleep, together with the suppression of oxidative stress, AChE, and GABA-T in the cerebral cortex and hippocampus. These results suggest the protective effect of AO against anxiety, insomnia, and memory impairment that coexist with the MetS condition via an improvement in oxidative stress and the functions of the cholinergic and GABAergic systems. However, this benefit requires clinical confirmation.

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Cited by 10 publications

References 33 publications

Protective Effects of Purple Waxy Corn on Aflatoxin B1-induced Oxidative Stress and Micronucleus in HepG2 Cells

Protective Effects of Purple Waxy Corn on Aflatoxin B1-induced Oxidative Stress and Micronucleus in HepG2 Cells

Cerebroprotective Effect against Cerebral Ischemia of the Combined Extract ofOryza sativaandAnethum graveolensin Metabolic Syndrome Rats

Anxiety, Insomnia, and Memory Impairment in Metabolic Syndrome Rats Are Alleviated by the Novel Functional Ingredients from Anacardium occidentale

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