Functionality of cow milk naturally enriched with polyunsaturated fatty acids and polyphenols in diets for diabetic rats

Abstract

The increasing incidence of diabetes mellitus is becoming a serious threat to human health in various parts of the world. Studies with dairy products have shown a potential beneficial effect against diabetes. This experiment evaluated the supplementation of milk naturally enriched with polyunsaturated fatty acids (PUFA) and polyphenols in rats with streptozotocin-induced diabetes. Forty male 28-day-old Wistar rats were distributed in four experimental treatments of diabetic animals (streptozotocin induction) and a normal group (non-induced). Experimental treatments were: control (water), whole common milk (COM-M), milk enriched with PUFA (PUFA-M), milk enriched with PUFA and polyphenols (PUFA/P-M) through a special diet offered to dairy cows. Milk supplementation at a dose 5 mL/kg body weight was performed for 77 days, 42 days before and 35 days after diabetes induction. The COM-M supplementation increased brown fat deposits, reduced post-induction glucose levels, reduced blood fructosamine levels, and improved glucose tolerance. Milk enriched with PUFA reduced final fasting glucose, LDL levels, and improved blood antioxidant capacity. Milk enriched with PUFA and polyphenols promoted an increase in gastrocnemius muscle mass, and a reduction in mesenteric fat and LDL levels. Milk intake, with an emphasis on milk enriched with PUFA and polyphenols, attenuated the metabolic disorders of streptozotocin-induced diabetes in rats.

Effects of Flaxseed Oil and Vitamin E Supplementation on Digestibility and Milk Fatty Composition and Antioxidant Capacity in Water Buffaloes

“…It has been shown that PUFA are deleterious to microorganisms [ 11 ] and mainly affect those that degrade the cell wall, since these FA have a cytotoxic effect [ 35 ]. The reduction in the total digestibility of NDF and ADF differs from the findings of Yoshimura et al [ 36 ], who added the same amount of flaxseed oil into the diets of dairy cows and did not have differences in these parameters.…”

Fatty acids, health indices and sensory properties of Ricotta cheese from sheep fed three different diets

“…Human studies have shown the benefits of naturally enriched products on atherosclerotic markers and low‐density lipoprotein (LDL) levels in various studies such as Wang et al () and Pintus et al (). Yoshimura et al () performed a laboratory experiment to evaluate their effect on patients suffering from diabetes. Implementing oilseed as a natural enrichment to the typical diet of dairy ewes is a common method for improving milk quality by increasing the UFA content, both for pasture‐based diets and for farm‐rationed diets (Cabiddu et al ).…”

Effect of cow’s milk with different PUFA n-6: n-3 ratios on performance, serum lipid profile, and blood parameters of grower gilts

“…Milk enriched with PUFA showed a reduction in the concentration of LDL in the blood of rats [ 14 ], and in gilts supplemented with cow’s milk naturally enriched with n-3 and n-6 from 34 days of age until the end of lactation also showed a reduction in LDL for the n-3 and n-6 treatments and improved the performance of weaned piglets [ 15 ]. However, we did not find studies evaluating the effects of providing PUFA-enriched milk on the development of pigs, considering the pig as an animal model for humans.…”