Fundamental Research for the Pharmacological Activity of Oriental Drugs. I

Kimura, Masashi; Yoshizaki, Masao; Muro, Ikuko; Shiho, Den-itsu

doi:10.1248/yakushi1947.85.7_570

Cited by 5 publications

(3 citation statements)

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“…It has long been used for treatment of headaches and nasal diseases, as a tranquilizer and analgesic, and is considered to be especially efficacious for empyem, chronic inflammation of paranasal sinuses. It has been pharmacologically found to act as an inhibitor on the central nervous system (1,2), to effect neuro-muscular blocking (3,4), and to possess anti-allergic effects (5).…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Effect of Neolignans Newly Isolated from the Crude Drug “Shin-i” (Flos Magnoliae)

Kimura

Suzuki²,

Yamada³

et al. 1985

Planta Med

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The anti-inflammatory effects of the major components of the dried flower buds of MAGNOLIA SALICIFOLIA were determined using the pouch granuloma method in mice. Though alkaloids, fatty acids, essential oils, and lignans had no anti-inflammatory effects, neolignans (magnoshinin and magnosalin) significantly inhibited the granuloma tissue formation. The inhibitory effect of magnoshinin was particularly strong, being nearly half of that of hydrocortisone acetate when administered orally. Some differences were noted in the mode of action between the neolignans and the steroidal drugs as the neolignans selectively inhibited the granuloma tissue formation but did not affect the exudation of pouch fluid. The structural specificity of neolignans was also found on their anti-inflammatory effect.

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Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Effect of Neolignans Newly Isolated from the Crude Drug “Shin-i” (Flos Magnoliae)

Kimura

Suzuki²,

Yamada³

et al. 1985

Planta Med

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“…It should be noted that the so-called "base-A11" [1] was found to be identical with 1 hydrochloride. …”

Section: Chemicalmentioning

confidence: 96%

“…In the previous paper [1], we reported that crude alkaloidal fractions prepared from "Shin-i" (dried buds of Magnolia salicifolia MAXIM and Magnolia fargesii CHENG) [2] inhibited acetylcholine (ACh)-induced contractions in the rectus abdominous muscles of frogs. We also reported the isolation of a crystalline phenolic alkaloid, tentatively named base-A11, which had curare-like activity.…”

Section: Introductionmentioning

confidence: 99%

Neuromuscular Blocking Action of Alkaloids from a Japanese Crude Drug “Shin-I” (Flos Magnoliae) in Frog Skeletal Muscle

Kimura

Yoshizaki

et al. 1983

Planta Med

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Fromthe dried buds of Magnolia salicifolia MAXIM, d-coclaurine (1), d-reticuline (2), 1-N-methylcoclaurifle (3) and yuzirine (4) were isolated. Fifty percent inhibitory doses (1iM) in acetyicholine (ACh, 27.5 tM)-induced contraction of frog skeletal muscle were as follows: d-tubocuraine (d-TC) 3.09, 2 93.2, 3211, 1 467 and 4 more than 945. 4 (94.5 and 315 tM) increased the ACh-induced contraction. Indirectly stimulated twitching of frog nerve-muscle preparations were completely blocked by the following doses (.tM): d-TC 1.47, 1 31.1, 2 239 and 3 more than 257. 1, 2 and 3 did not or only slightly block directly stimulated twitching. In contrast 271 1tM 4 blocked the directly stimulated twitching.

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