This report represented of pig diseases from the Special Region of Yogyakarta, Indonesia during 2018-2019. This research was done to describe the incidence rate of pig diseases and aimed to treat, prevent and control the pig diseases so as not to cause deaths, economic losses and prevention of disease to human (zoonoses). This study have been based on disease cases in Pathology Laboratory of Faculty of Veterinary Medicine, University of Gadjah Mada (FKH UGM), the Special Region of Yogyakarta since 2018-2019. A total of 80 cases of pig diseases have been examined at the Pathology Laboratory of FKH UGM since 2018-2019. The result of data analysis showed that the highest infection was caused by bacterial infections, 48/80 (60%). The bacteria included Pasteurella sp., Salmonella sp., Bordetella sp., E.coli, and Actinobacillus sp.. Beside of bacteria, The infections were caused by parasite and viral infection. The case of parasite infection was 30/80 (37.5%), as Trichuris sp., Metastrongylus sp., Ascaris sp., and Eimeria sp. There was only two cases of viral infection, Clasical Swine Fewer. Generally, clinical signs of pigs were respiratory disorder, nasal discharge, cough, and weak. Pathological changes in cases of the disease included rhinitis, tracheitis, pneumonia, enteritis, and hepatitis. The conclusion of this study showed that the highest cases of pigs diseases in the Special Region of Yogyakarta was bacterial and parasitic infections. They caused pathological changes in various organs such as lung, intestine, nasal sinuse, trachea and hepar.