GC–MS metabolomics revealed protocatechuic acid as a cytotoxic and apoptosis-inducing compound from black rice brans

Yuliana, Nancy Dewi; Tuarita, Mirna Zena; Khatib, Alfi; Laila, Farida; Sukarno, Sukarno

doi:10.1007/s10068-019-00725-2

Cited by 8 publications

(6 citation statements)

References 33 publications

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“…MDA-MB-231 is a more aggressive late-stage model of breast cancer, which would explain the difference in activity observed between MCF-7 and MDA-MB-231. Contrary to our results, a previous study with protocatechuic acid from black rice bran has indicated that purified protocatechuic acid can induce apoptosis in cells even with range of low concentrations such as 10-50 µg/ml (20). Similarly, numerous studies have reported the effect of procyanidin B type dimer and trimers to be effective against cancer cells (22,23,41).…”

Section: Discussioncontrasting

confidence: 99%

“…A human study demonstrated an increase in antioxidant activity even with a single dose of date seed products such as DSE, date seed powder (DSP), and date seed supplemented Arabic pita bread (DSB) (18). Moreover, many polyphenols such as catechin, epicatechin, p-hydroxybenzoic acid, protocatechuic acid, and procyanidins have reported anti-tumour property (19)(20)(21)(22)(23)(24). Although these compounds are abundant in DS, there is no detailed investigation of the anti-tumour potential of DS.…”

Section: Introductionmentioning

confidence: 99%

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In-vitro Investigation of Polyphenol-Rich Date (Phoenix dactylifera L.) Seed Extract Bioactivity

et al. 2021

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Date seeds are a by-product of the date fruit processing industry with minimal human use; however, they are a rich source of polyphenols with a range of potential biological properties. The current study investigates the cytotoxicity of date seed polyphenols against cancer cell lines, its ability to combat hyperglycemia, its antioxidant potential and its anti-adipogenic effect. The present work aimed to establish the usefulness of date seeds in the food industry as a functional ingredient. The anti-tumour activity of DSE was tested in a panel of cell lines such as MCF-7, MDA-MB-231, Hep-G2, Caco-2, and PC-3 by measuring cell viability and cleaved PARP. Lipid accumulation and effect on the differentiation of 3T3-L1 cells (adipocytes) were tested with date seed extract treatments. The influence of date seed polyphenols on glucose uptake was studied in 3T3-L1 cells and C2C12 cells (muscle cells). The antioxidant activity of the polyphenols from date seed products such as date seed extract (DSE), date seed powder (DSP), and date seeds fortified bread (DSB) was tested following in-vitro digestion to study their stability in the gastrointestinal milieu. DSE treatment resulted in significantly reduced viability in MCF-7 and Hep-G2 cells with 48-h treatments. Glucose uptake increased in the adipocytes with DSE treatments; moreover, it inhibited adipocyte differentiation and lipid accumulation. DSE decreased the expression levels of PPAR-γ, C/EBPα, adiponectin and upregulated GLUT-4, and phospho-AMPK. This study also found that date seed samples retained antioxidant activity in the digestive milieu and concludes that the date seed polyphenols remain active in the digestive milieu and exhibit potential anti-hyperglycemic and anti-adipogenic activity.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In-vitro Investigation of Polyphenol-Rich Date (Phoenix dactylifera L.) Seed Extract Bioactivity

et al. 2021

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“…Histopathological examination commonly contains immature tissue in various amounts. Most common are neuroectodermal (16) tubules and rosettes, but occasionally with active glial cell components, mitosis in significant amounts mixed with ectodermal and endodermal elements with varying levels of maturation. Neuroectodermal tubules are coated by hyperchromatic cells arranged in a stacked way with many mitose and may also contain pigments.…”

Section: Discussionmentioning

confidence: 99%

Immature Teratoma Ovarium in Young Women: Two Case Reports and Literature Reviews

et al. 2022

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“…At the same dose level, it also activated the extrinsic pathway by modulating caspase-8. On the other hand, PCA showed positive regulation of caspase-1 and caspase-7 at higher doses (25-50 µg/mL), suggesting its possible involvement in proinflammatory cell death [79].…”

Section: Mechanism Of Apoptotic Action In Pcamentioning

confidence: 93%

The Cancer-Protective Potential of Protocatechuic Acid: A Narrative Review

Cadena-Iñiguez,

Santiago-Osorio,

Sánchez-Flores

et al. 2024

Molecules

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Cancer is one of the leading causes of death worldwide, making the search for alternatives for its control a critical issue. In this context, exploring alternatives from natural sources, such as certain vegetables containing a variety of secondary metabolites with beneficial effects on the body and that play a crucial role in the fight against cancer, is essential. Among the compounds with the greatest efficacy in controlling this disease, those with antioxidant activity, particularly phenolic com-pounds, stand out. A remarkable example of this group is protocatechuic acid (PCA), which has been the subject of various revealing research on its activities in different areas. These studies sustain that protocatechuic acid has anti-inflammatory, antimutagenic, antidiabetic, antiulcer, antiviral, antifibrogenic, antiallergic, neuroprotective, antibacterial, anticancer, antiosteoporotic, anti-aging, and analgesic properties, in addition to offering protection against metabolic syndrome and con-tributing to the preservation of hepatic, renal, and reproductive functionality. Therefore, this paper aims to review the biological activities of PCA, focusing on its anticancer potential and its in-volvement in the control of various molecular pathways involved in tumor development, sup-porting its option as a promising alternative for cancer treatment.

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GC–MS metabolomics revealed protocatechuic acid as a cytotoxic and apoptosis-inducing compound from black rice brans

Cited by 8 publications

References 33 publications

In-vitro Investigation of Polyphenol-Rich Date (Phoenix dactylifera L.) Seed Extract Bioactivity

In-vitro Investigation of Polyphenol-Rich Date (Phoenix dactylifera L.) Seed Extract Bioactivity

Immature Teratoma Ovarium in Young Women: Two Case Reports and Literature Reviews

The Cancer-Protective Potential of Protocatechuic Acid: A Narrative Review

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