GC–MS Quantitation and Identification of Bisphenol-A Isolated from Water

Abstract

b S Supporting Information O ne of the biggest challenges in trace organic analysis is concentrating any given sample enough to reliably identify and quantitate above the method detection limit. There are several ways to do this depending on the sample matrix. For aqueous samples, liquidÀliquid extraction can be used to partition an analyte to the organic solvent layer. Another example is solid-phase extraction (SPE) where the aqueous layer is passed through a solid phase to selectively extract the analyte of interest. SPE offers a variety of advantages over liquidÀliquid extraction because (i) different solid phases can be used to selectively partition analytes from the aqueous phase, (ii) large sample volumes can be passed through the SPE column, and (iii) organic solvent use is minimized. Similar experiments published in this Journal have used SPE to isolate and GCÀMS to quantitate and characterize trace organic components. 1À4 Trace organic analysis is especially important for compounds that pose human health and environmental risks. One compound that has received considerable research and public interest is bisphenol-A (4-4 0 -isopropylidenediphenol) (Figure 1) due to its endocrine disrupting properties. 5 Bisphenol-A (BPA) is a monomer used in polycarbonate plastic products and other products such as epoxy resins, adhesives, optical coatings, and so forth. 6 Recently, it has been shown that BPA is leached from a wide variety of products such as bottles, plastic food wrappers, and resin-lined food cans. 7,8 One method that is suitable for the detection and quantitation of trace organic compounds is gas chromatographyÀmass spectrometry (GCÀMS).GCÀMS is ideal for undergraduate level experiments because it is used in many fields of chemistry in both academic and industrial settings due to its low cost, ease of use, and minimum

Bisphenol A and Metabolites in Meat and Meat Products: Occurrence, Toxicity, and Recent Development in Analytical Methods

“…This is probably due to benzylic carbocation, resulting in the loss of methyl group from BPA. The resulting ion with m/z 213 was very stable resulting in it being the base peak in the mass spectrum [ 28 ]. Munguia–Lopez et al reported m/z 213 as the main ion with further fragments including m/z 228 (molecular ion), 110, and 91 [ 115 ].…”

“…For example, Denmark, France, Sweden, and Belgium have restricted the use of BPA in food packaging for young children. Denmark imposed a ban on the use of BPA for the manufacturing of plastic materials in contact with food intended for children aged 0–3 years [ 28 ]. In 2012, France adopted a law of suspending all BPA containing materials coming into contact with foods intended for children of 0–3 years of age from January 2013, and all other food contact materials from January 2015 [ 29 ].…”

Graphene grafted magnetic microspheres for solid phase extraction of bisphenol A and triclosan from water samples followed by gas chromatography-mass spectrometric analysis

“…Their high polarities require prior derivatization before the GC/MS analysis, so as to reduce their polarity and enhance their volatility. As a commonly used derivative agent for phenols or alcohols, BSTFA 28 was selected as the derivative agent for their derivatization in the current study.…”

A Sensitive Electrochemical Sensor Based on Co3O4‐CeO2 Composites Modified Glassy Carbon Electrode for the Determination of Bisphenol A

“…A variety of analytical approaches have been used to detect BPA, such as gas chromatography-mass spectrometry (GC-MS), [5] fluorometry, [6] enzyme-linked immunosorbent assay, [7] liquid chromatography-mass spectrometry (LC-MS), [8] high performance liquid chromatography (HPLC), [9] high performance liquid chromatography coupled to UV, [10] molecular imprinting technique, [11] electrochemical method. [12] Although these methods are accurate and sensitive, their application is often limited due to the complexity of the operation and the high cost of the instrument.…”