Genetic polymorphisms of phase I and phase II metabolic enzymes as modulators of lung cancer susceptibility

Mota, Paula; Silva, Henriqueta Coimbra; Soares, Mafalda; Pêgo, Alice; Loureiro, Melina Bezerra; Cordeiro, Carlos Robalo; Regateiro, Fernando

doi:10.1007/s00432-014-1868-z

Cited by 21 publications

(15 citation statements)

References 38 publications

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“…This inverse association was greater in GSTM1/ GSTT1-null subjects than non-null subjects, particularly in those with a deletion of both genes. An interaction between alcohol intake and GSTM1 or GSTT1 was reported previously in cancer of the breast, lung, and stomach [33][34][35]. Our study is the first report of such an interaction in thyroid cancer.…”

Section: Interaction With Alcohol Drinking and Tobacco Smokingsupporting

confidence: 81%

Role of GSTM1 and GSTT1 genotypes in differentiated thyroid cancer and interaction with lifestyle factors: Results from case-control studies in France and New Caledonia

et al. 2020

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Background GSTM1 and GSTT1 are involved in detoxification of xenobiotics, products of oxidative stress and in steroid hormones metabolism. We investigated whether GSTM1 and GSTT1 gene deletion was associated with DTC risk and explored interaction with non-genetic risk factors of DTC. MethodsThe study included 661 DTC cases and 736 controls from two case-control studies conducted in France and New Caledonia. Odds ratios (OR) and their confidence interval (CI) for DTC associated with GST genotypes, alcohol drinking, tobacco smoking, body mass index and hormonal factors were calculated using logistic regression models. ResultsResults are presented for Europeans and Melanesians combined, as no heterogeneity between groups was detected. We found that DTC risk increased with obesity and decrease with alcohol drinking. After stratification by gene deletion status, the OR for obesity was 5.75, (95%CI 2.25-14.7) among individuals with GSTT1 and GSTM1-deleted genotype, and 1.26, (95%CI 0.89-1.77) in carriers of both genes (p-interaction = 0.02). The OR for drinking �1 glass/week was 0.33 (95%CI 0.15-0.74) in GSTT1-null individuals while it was 1.01 (95%CI 0.67-1.52) in non-null carriers of the gene (p-interaction = 0.01). No interaction between GST genotypes and other non-genetic risk factors was detected.

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Section: Interaction With Alcohol Drinking and Tobacco Smokingsupporting

confidence: 81%

Role of GSTM1 and GSTT1 genotypes in differentiated thyroid cancer and interaction with lifestyle factors: Results from case-control studies in France and New Caledonia

et al. 2020

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“…Studies have shown that abnormal expression levels of genes related to the metabolism of carcinogens in cells, such as those that encode the CYP superfamily of proteins, the GST superfamily of proteins, or the DNA repair-associated proteins, might lead to an increase in the risk of developing cancer (Li et al, 2014;Mota et al, 2015;Zhao et al, 2015). In the present study, we used PCR and PCR-RFLP to investigate gene polymorphisms in key respiratory chain genes that take part in DNA damage repair, including CYP1A1, GSTP1, ERCC2, XRCC1, and XRCC3.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, DNA damage repair-related gene expression levels have a major impact on the incidence of malignant tumors (Brosh, 2013). Mota et al (2015) found that genetic polymorphisms can influence the expression of genes and the activity of the proteins they encode, which may ultimately affect an individual's risk of developing cancer (Chen et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Correlation between gene polymorphisms of CYP1A1, GSTP1, ERCC2, XRCC1, and XRCC3 and susceptibility to lung cancer

Liu

2016

Genet. Mol. Res.

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ABSTRACT. Lung cancer is a common malignant tumor that is characterized by high morbidity and poor prognosis. Studies suggest that an individual's genetic background affects the risk of developing lung cancer. Therefore, we investigated the relationship between gene polymorphisms and susceptibility to lung cancer. We recruited 308 primary lung cancer patients as subjects and 253 healthy adults as controls. After extraction of DNA from blood samples, gene polymorphisms in CYP1A1, GSTP1, ERCC2, XRCC1, and XRCC3 were investigated by polymerase chain reaction and restriction fragment length polymorphism. The frequencies of the genotypes in both groups were investigated to obtain odds ratios and 95% confidence intervals, and correlation analysis was carried out. The analysis results showed that the following polymorphisms were correlated with susceptibility to lung cancer: rs4646903 in CYP1A1 (P < 2 H.X. Liu et al.Genetics and Molecular Research 15 (4): gmr15048813 0.001), rs1048943 in CYP1A1 (P < 0.001), rs1695 in GSTP1 (P < 0.05), rs13181 in ERCC2 (P < 0.001), and rs25487 in XRCC1 (P < 0.05); no such correlation existed in rs861539 in XRCC3 (P > 0.05). The study revealed that the more high-risk gene polymorphisms a patient carries, the greater the risk of developing lung cancer. Carriers of rs4646903 in CYP1A1, rs1048943 in CYP1A1, rs1695 in GSTP1, rs13181 in ERCC2, and rs25487 in XRCC1 are more likely to develop lung cancer.

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“…Some studies found no effect of NAT2 polymorphism on lung cancer risk [9,12,19,20,22]. In other studies, the slow acetylation phenotype of NAT2 may increase the risk of lung cancer [6,10,14,15,21,24,25]. However, other researchers have suggested that rapid acetylation phenotypes may increase the risk of lung cancer [16][17][18]26].…”

Section: Discussionmentioning

confidence: 99%

“…Individual differences in activities of these enzymes can in uence the biological responses to xenobiotic exposure, cancer susceptibility, and eventual adverse drug reactions [5,6]. N-acetyltransferase 2 (NAT2) is polymorphic and widely exists in lung, colon, breast, prostate and liver [7].…”

Section: Introductionmentioning

confidence: 99%

Effects of NAT2 Polymorphism on Lung Cancer Risk, and the Interaction Between Smoking and NAT2: A Meta-analysis

Zhu

Xu²,

Zhang

et al. 2020

Preprint

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Background Lung cancer is the most common cancer in the world, and cancer death is mainly caused by lung cancer. At present, the etiology and pathogenesis of lung cancer are not clear. N-acetyltransferase 2 (NAT2) is an enzyme found in the lungs, colon, breast, prostate, and liver. NAT2 is polymorphic and can metabolize carcinogens from tobacco smoke. At present, many studies have explored the effects of NAT2 polymorphism on lung cancer, but we found inconsistent results. Methods We conducted a research of 19 published studies, involving 4,130 patients and 6,057 controls, to more accurately assess the effects of NAT2 polymorphism on lung cancer risk and to investigate whether smoking is associated. We used STATA software to analyze the extracted data and used STATA for subgroup analysis, sensitivity analysis, and to perform publication bias tests. To determine the correlation, we used the crude odds ratio (ORs) with 95% confidence interval (CIs). Results From the major results, we found that there was no significant correlation between NAT2 polymorphism and lung cancer (OR = 1.00, 95% CI: 0.84–1.19, I² = 63.3%, P < 0.001 for heterogeneity). We also found no significant results in stratified analyses of smoking, ethnicity, gender, and source of controls. However, we learned from the subgroup analysis that the lung cancer risk in NAT2 patients with intermediate-slow acetylation may be increased (OR = 1.83, 95% CI: 1.22–2.73, I² = 39.6%, P = 0.191 for heterogeneity). Conclusions This research showed that no sufficient evidence was found to prove the effect of NAT2 polymorphism on lung cancer risk; however the increased acetylation capacity of NAT2 might reduce the risk of lung cancer.

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Genetic polymorphisms of phase I and phase II metabolic enzymes as modulators of lung cancer susceptibility

Cited by 21 publications

References 38 publications

Role of GSTM1 and GSTT1 genotypes in differentiated thyroid cancer and interaction with lifestyle factors: Results from case-control studies in France and New Caledonia

Role of GSTM1 and GSTT1 genotypes in differentiated thyroid cancer and interaction with lifestyle factors: Results from case-control studies in France and New Caledonia

Correlation between gene polymorphisms of CYP1A1, GSTP1, ERCC2, XRCC1, and XRCC3 and susceptibility to lung cancer

Effects of NAT2 Polymorphism on Lung Cancer Risk, and the Interaction Between Smoking and NAT2: A Meta-analysis

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