Genetic Relationship Between <i>IL-6</i> rs1800796 Polymorphism and Susceptibility to Periodontitis

Zhao, Bo; Li, Xiaoqian; Li, Ronghua

doi:10.1080/08820139.2018.1517365

Cited by 16 publications

(14 citation statements)

References 46 publications

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“…A recent meta-analysis included 18 studies as well as the suspected duplicated ones from two groups of studies 20,46,51,55 exploring relationship between rs1800796 and periodontitis reported significant association between the two, be that Asians only or all subjects included. 22 The present report, excluding the suspected duplicated data, adding data from two latest studies 20,51 and current report confirmed such observation. However, because of putting central Asian participants' data under Caucasians, Zhao et al 22 reported rs1800796 did not associate with periodontitis in the latter.…”

Section: F I G U R E 5 Forest Plot On 18 Studies For the Association Between The G Allele Of The Il6 Rs1800796 And Periodontitis In (A) Asupporting

confidence: 84%

“…We postulated that the same SNPs reported by Song et al 21 . and Zhao et al 22 . would be significantly associated with periodontitis in the cohorts followed.…”

Section: Introductionmentioning

confidence: 56%

“…Here we carried out a candidate gene study on periodontitis, based upon the aforementioned hypothesis, to investigate the association between periodontal disease and SNPs of genes known to control or regulate Th2 cell differentiation (CD28, CTLA4, IL-4R, GATA3, STAT6) and Th2 cell effector molecules production (IL-4, IL-5, IL-6, IL-9, IL-10, IL-13) in Chinese nonsmokers. We postulated that the same SNPs reported by Song et al 21 and Zhao et al 22 would be significantly associated with periodontitis in the cohorts followed.…”

mentioning

confidence: 56%

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Th2 cell regulatory and effector molecules single nucleotide polymorphisms and periodontitis

Zheng

Chai²,

Fan

et al. 2020

Journal of Leukocyte Biology

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Section: F I G U R E 5 Forest Plot On 18 Studies For the Association Between The G Allele Of The Il6 Rs1800796 And Periodontitis In (A) Asupporting

confidence: 84%

“…We postulated that the same SNPs reported by Song et al 21 . and Zhao et al 22 . would be significantly associated with periodontitis in the cohorts followed.…”

Section: Introductionmentioning

confidence: 56%

mentioning

confidence: 56%

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Th2 cell regulatory and effector molecules single nucleotide polymorphisms and periodontitis

Zheng

Chai²,

Fan

et al. 2020

Journal of Leukocyte Biology

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“…[27–30] The genetic variation for IL-6 is associated with diseases caused by abnormal inflammatory responses. [14,31] Studies have shown that IL-6 expression levels are abnormally elevated after acute inflammatory response, [32] so we believe that the abnormal expression of IL-6 , caused by IL-6 gene polymorphism, may be related to the occurrence and development of ARDS. It can be seen from the results of this study that the G allele at IL-6 rs1800796 is a risk factor for ARDS, and the plasma IL-6 level in the population carrying the G allele is significantly higher than in the C allele carrier population, which may be one of the main causes of ARDS.…”

Section: Discussionmentioning

confidence: 99%

TLR4/NF-κB signaling pathway gene single nucleotide polymorphisms alter gene expression levels and affect ARDS occurrence and prognosis outcomes

Ding

Feng²,

Chen

et al. 2019

Medicine

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Background: To study the occurrence and prognosis of acute respiratory distress syndrome (ARDS) using single nucleotide polymorphisms (SNPs) of TNF-α rs1800629, IL-6 rs1800796, and MyD88 rs7744 loci in the TLR4/NF-κB pathway. Methods: Genotypes were analyzed for TNF-α rs1800629, IL-6 rs1800796, and MyD88 rs7744 loci. Plasma TNF-α and IL-6 levels and MyD88 mRNA expression in peripheral blood mononuclear cells (PBMCs) of 300 ARDS patients and 300 non-ARDS patients (control group) were examined. The patients were followed up for 60 days, and the prognosis outcome was recorded. Results: The TNF-α rs1800629 locus A allele and the IL-6 rs1800796 locus G allele were found to be risk factors for ARDS (adjusted OR = 1.452, 95% CI: 1.211–1.689, P < .001 and adjusted OR = 1.205, 95% CI: 1.058–1.358, P = .005, respectively). The G allele at MyD88 rs7744 locus was a protective factor against ARDS (adjusted OR = 0.748, 95% CI: 0.631–0.876, P < .001). Compared with the other groups, homozygotes for TNF-α rs1800629, IL-6 rs1800796, and MyD88 rs7744 loci had higher expression levels, of which homozygotes for TNF-α rs1800629 and IL-6 rs1800796 loci had lower 60-day survival rates, while MyD88 rs7744 locus homozygotes had a higher 60-day survival rate. Conclusion: The effect of TNF-α rs1800629, IL-6 rs1800796, and MyD88 rs7744 SNPs on gene expression level is a likely cause of ARDS occurrence and poor prognosis.

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“…The levels of salivary IL-6 appear to be increased in patients affected by Chronic Periodontitis as compared to healthy controls [95]. Interleukin-6 572C/G and RS1800796 polymorphisms appear as genetic risk factors for periodontitis patients in the Asian population [96,97]. Its sensitivity ranged from 52% to 80%, and specificity ranged from 48% to 87% [31,84,85,93]; • Hemoglobin(HB): This has a sensitivity value of 72% and a specificity value of 75% [19].…”

mentioning

confidence: 99%

Predictive Periodontitis: The Most Promising Salivary Biomarkers for Early Diagnosis of Periodontitis

Cafiero

Spagnuolo

Marenzi

et al. 2021

JCM

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The primary cause of tooth loss in the industrialized world is periodontitis, a bacterial anaerobic infection whose pathogenesis is characterized by composite immune response. At present, the diagnose of periodontitis is made by a complete status check of the patient’s periodontal health; full-mouth plaque score, full-mouth bleeding score, probing depth, clinical attachment level, bleeding on probing, recessions, mobility, and migration are evaluated in order to provides a clear picture of the periodontal conditions of a single patient. Chair-side diagnostic tests based on whole saliva could be routinely used by periodontists for a very early diagnosis of periodontitis, monitoring, prognosis, and management of periodontal patients by biomarker detection, whose diagnostic validity is related to sensitivity and specificity. Recent paper reviews and meta-analyses have focused on five promising host derived biomarkers as candidate for early diagnosis of periodontitis: MMP-8 (Metalloproteinase-8), MIP-1α (Macrophage inflammatory protein-1 alpha), IL-1 β (Interleukin-1 beta), IL-6 (Interleukin-6), and HB (Hemoglobin), and their combinations. Chair-side Lab-on-a-chip (LOC) technology may soon become an important part of efforts to detect such biomarkers in saliva medium to improve worldwide periodontal health in developed nations as well as in underserved communities and poor countries. Their applications in preventive and predictive medicine is now fundamental, and is aimed at the early detection of risk factors or the presence or evolution of the disease, and in personalized medicine, which aims to identify tailor-made treatments for individual patients. The aim of the present paper is to be informative about host derived periodontal biomarkers and, in particular, we intend to report information about the most important immune response derived biomarkers and Hemoglobin as candidates to be routinely utilized in order to obtain a chair-side early diagnosis of periodontal disease.

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Genetic Relationship Between IL-6 rs1800796 Polymorphism and Susceptibility to Periodontitis

Cited by 16 publications

References 46 publications

Th2 cell regulatory and effector molecules single nucleotide polymorphisms and periodontitis

Th2 cell regulatory and effector molecules single nucleotide polymorphisms and periodontitis

TLR4/NF-κB signaling pathway gene single nucleotide polymorphisms alter gene expression levels and affect ARDS occurrence and prognosis outcomes

Predictive Periodontitis: The Most Promising Salivary Biomarkers for Early Diagnosis of Periodontitis

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