Genetic variability of the tumorous-head maternal effect in Drosophila melanogaster

A new homoeotic mutant, I127, showing abnormal growths in the head region including homoeotic transformation of eye to genitalia and antenna to leg, was isolated in a screen designed to find new alleles of the tumourous head (tuh-3), mutation. Similarities in the phenotype and genetics of the mutant, and complementation studies with tuh-I; tuh-3, suggest that I127 is indeed an allele of tuh-3. In combination with the first chromosome modifier tuh-1, the mutant is temperature-sensitive during the third larval instar, giving an increased penetrance of the tumorous head phenotype when reared at 25 degrees C as opposed to 18 degrees C. The isolation of further alleles at the tumorous-head locus are essential. The type of morphological defects which can result from mutations at this locus would enable us to establish if this is a complex locus, and if null mutations are lethal during development. The interactions of the tumorous-head gene with first chromosome modifiers and other homoeotic mutations will only be understood if we are able to induce a number of mutations at this locus, and as a consequence begin to elucidate the role of the wild-type gene product in normal development.

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Characterisation of a new tumorous-head mutant of Drosophila melanogaster

Bownes

Roberts

Dempster

et al. 1981

Molec. Gen. Genet.

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Thoracic abnormalities in tumorous-headDrosophila melanogaster

Nickla

Carney

1984

Wilhelm Roux' Archiv

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Developmental-genetic properties of thoracic abnormalities are described intumorous-head (tuh-1; tuh-3) Drosophila melanogaster. Approximately 7% of females from an unselected strain have abnormal thoracic appendages (primarily metathoracic) ranging from missing to duplicated. When multiple, these abnormalities are generally unilateral and contiguous. Results of reciprocal crosses indicated that, as with head defects, thoracic defects are maternally affected. A major modifier,enhancer of tuh-1, of the maternal effect shifts the distribution of thoracic defects anteriorly and increases the frequency of head defects. We suggest that thetumorous-head system illustrates a genetic influence over an anterior-posterior gradient inD. melanogaster.

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Tumorous-head-type mutants of the distal bithorax complex cause dominant gain and recessive loss of function in Drosophila melanogaster

Kuhn

Packert

1988

Developmental Biology

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Genetic variability of the tumorous-head maternal effect in Drosophila melanogaster

Cited by 6 publications

References 23 publications

Characterisation of a new tumorous-head mutant of Drosophila melanogaster

Characterisation of a new tumorous-head mutant of Drosophila melanogaster

Thoracic abnormalities in tumorous-headDrosophila melanogaster

Tumorous-head-type mutants of the distal bithorax complex cause dominant gain and recessive loss of function in Drosophila melanogaster

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