Genetic variants in MIR17HG affect the susceptibility and prognosis of glioma in a Chinese Han population

Abstract

Background: lncRNA MIR17HG was upregulated in glioma, and participated in promoting proliferation, migration and invasion of glioma. However, the role of MIR17HG polymorphisms in the occurrence and prognosis of glioma is still unclear.Methods: In the study, 592 glioma patients and 502 control subjects were recruited. Agena MassARRAY platform was used to detect the genotype of MIR17HG polymorphisms. Logistic regression analysis was used to evaluate the relationship between MIR17HG single nucleotide polymorphisms (SNPs) and glioma risk by odds ratio (OR) and 95% confidence intervals (CIs). Kaplan–Meier curves, Cox hazards models were performed for assessing the role of these SNPs in glioma prognosis by hazard ratios (HR) and 95% CIs.Results: We found that rs7318578 (OR = 2.25, p = 3.18´10-5) was significantly associated with glioma susceptibility in the overall participants. In the subgroup with age < 40 years, rs17735387 (OR = 1.53, p = 9.05´10-3) and rs7336610 (OR = 1.35, p = 0.016) were related to the higher glioma susceptibility. More importantly, rs17735387 (HR = 0.82, log-rank p = 0.026) were associated with the longer survival of glioma patients. The GA genotype of rs17735387 had a better overall survival (HR = 0.75, log-rank p = 0.013) and progression free survival (HR = 0.73, log-rank p = 0.032) in patients with Ⅰ-Ⅱ glioma. We also found that rs72640334 was related to the poor prognosis (HR = 1.49, Log-rank p = 0.035) in female patients. In the subgroup of patients with age ³ 40 years, rs17735387 was associated with a better prognosis (HR = 0.036, Log-rank p = 0.002).Conclusion: Our study firstly reported that MIR17HG rs7318578 was a risk factor for glioma susceptibility and rs17735387 was associated with the longer survival of glioma among Chinese Han population, which might help to enhance the understanding of MIR17HG gene in gliomagenesis.

Long non‑coding RNA MIR17HG sponges microRNA‑21 to upregulate PTEN and regulate homoharringtonine‑based chemoresistance of acute myeloid leukemia cells

“…Recently, it has been reported that MIR17HG was associated with several types of cancer, such as non-small cell lung cancer and cervical squamous cell carcinoma (22,23). Notably, genetic variants in MIR17HG were found to be associated with the susceptibility and prognosis of glioma in a Chinese Han population (24). These findings support the role of MIR17HG as a key regulator in cancer biology and as a potential target for cancer treatment.…”

The Expression of Serum lncRNA MIR17HG in Patients with Multiple Myeloma and Its Clinical Significance

“…DS and ISS are well-known prognostic tools, which stratify newly diagnosed MM patients into diferent risk groups based on widely used serum markers (such as ALB, β2-MG, and LDH) and represent a critical modality in predicting the survival of MM patients at diagnosis [30]. Te genetic variants in MIR17HG also exert a signifcant impact on the prognosis of glioma and susceptibility of head and neck squamous cell carcinoma in Chinese Han populations [31,32]. Moreover, we unraveled that MM patients at DS stage III possess higher serum MIR17HG expression levels than those at DS stages I-II, and the serum MIR17HG levels exhibited an increase with the development of ISS stages.…”