Genetically Engineered Polypeptide Adhesive Coacervates for Surgical Applications

Sun, Jing; Xiao, Lizu; Li, Bo; Zhao, Kelu; Wang, Zili; Zhou, Yu; Ma, Chao; Li, Jingjing; Zhang, Hongjie; Herrmann, Andreas; Li, Kai

doi:10.1002/anie.202100064

Cited by 95 publications

(93 citation statements)

References 53 publications

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“…For example, supercharged polypeptides (SUPs) and biomimetic synthetic surfactants can form non-swelling adhesive materials through electrostatic complexation. [93] SUP glue exhibited tissue adhesion and hemostatic effects in pig liver and kidney bleeding models, with bleeding inhibited within 10 s. [93] Peptide-based materials have excellent potential for wound hemostasis due to their ability to self-assemble into nanofibrous hydrogels. However, most hemostatic materials are only suitable for wounds with regular shapes and low blood flow.…”

Section: Rapid Hemostasismentioning

confidence: 99%

“…For example, supercharged polypeptides (SUPs) and biomimetic synthetic surfactants can form non‐swelling adhesive materials through electrostatic complexation. [ 93 ] SUP glue exhibited tissue adhesion and hemostatic effects in pig liver and kidney bleeding models, with bleeding inhibited within 10 s. [ 93 ]…”

Section: Rational Design Of Peptide‐based Hydrogels For Wound Treatmentmentioning

confidence: 99%

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Self‐Assembling Peptide‐Based Hydrogels for Wound Tissue Repair

et al. 2022

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Wound healing is a long-term, multistage biological process that includes hemostasis, inflammation, proliferation, and tissue remodeling and requires intelligent designs to provide comprehensive and convenient treatment. The complexity of wounds has led to a lack of adequate wound treatment materials, which must systematically regulate unique wound microenvironments. Hydrogels have significant advantages in wound treatment due to their ability to provide spatiotemporal control over the wound healing process. Self-assembling peptide-based hydrogels are particularly attractive due to their innate biocompatibility and biodegradability along with additional advantages including ligand-receptor recognition, stimulus-responsive self-assembly, and the ability to mimic the extracellular matrix. The ability of peptide-based materials to self-assemble in response to the physiological environment, resulting in functionalized microscopic structures, makes them conducive to wound treatment. This review introduces several self-assembling peptide-based systems with various advantages and emphasizes recent advances in self-assembling peptide-based hydrogels that allow for precise control during different stages of wound healing. Moreover, the development of multifunctional self-assembling peptide-based hydrogels that can regulate and remodel the wound immune microenvironment in wound therapy with spatiotemporal control has also been summarized. Overall, this review sheds light on the future clinical and practical applications of self-assembling peptide-based hydrogels.

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Section: Rapid Hemostasismentioning

confidence: 99%

Section: Rational Design Of Peptide‐based Hydrogels For Wound Treatmentmentioning

confidence: 99%

Self‐Assembling Peptide‐Based Hydrogels for Wound Tissue Repair

et al. 2022

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“…Such adhesion perfor mance might be related to the high potential for both chemical interactions and mechanical interlocking between PPTB and the surface. [32,33] A cycling test was then performed and showed that the adhesion performance could be recovered after recy cling (Figure S11, Supporting Information). Additionally, the adhesion strength was maintained in the air even after seven months (Figure S12, Supporting Information).…”

Section: Resultsmentioning

confidence: 99%

An Engineered Protein−Au Bioplaster for Efficient Skin Tumor Therapy

et al. 2022

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specificity in targeting melanoma cells and often harm surrounding healthy organs and tissues. [4,5] Besides, these conven tional therapies cannot effectively elimi nate tumors, thereby undertaking a high risk of recurrence. [6][7][8] The significant skin defects caused by surgery are also suscep tible to colonization by pathogenic bac teria, further leading to chronic wounds. On the other hand, multidrug resistance and autologous cell rejection are inevi table for emerging targeted therapies and immunotherapy. Alternatively, photo thermal therapies (PTT) have received tremendous attention for the treatment of tumors due to their minimal damage to tissues and low intrusiveness. [9][10][11][12][13] Nearinfrared (NIR) light has great tissue penetration depth, low autofluorescence, and absorption in the NIR region, which is suitable for melanoma's PTT treat ment. [14,15] Various NIRlightresponsive materials such as organic agents and inorganic nanoparticles (NPs) have been well investigated. [16][17][18] In particular, gold nanorods (GNRs) show exceptional optical absorption based on their tunable aspect ratios, which have served as promising photothermal agents in PTT due to their facile preparation, good biocompatibility, low toxicity, stable photothermal performance, and excellent photothermal con version efficiency. [19] Moreover, GNRs can lead to the covalent Melanoma is the most lethal malignancy in skin cancer and may occur at any site and express melanocytes. Due to malignant melanoma's invasion and migration nature, conventional therapies make it challenging to remove the whole tumor tissue while undertaking the high risks of tumor recurrence. Regarding the emerging targeted therapies and immunotherapy, drug resistance and low immunotherapeutic activity remain significant challenges. It is thus becoming urgently important to develop alternative strategies for melanoma therapy. Herein, a novel bifunctional protein-based photothermal bioplaster (PPTB) is developed for non-invasive tumor therapy and skin tissue regeneration. The complexation of adhesive protein and gold nanorods (GNRs) endow the obtained PPTB with good biocompatibility, controllable near-infrared (NIR) light-mediated adhesion performance, and high photothermal performance. Therefore, the PPTB bioagent facilitates skin adhesion and effectively transfers heat from skin to tumor. This behavior endows PPTB capability to eradicate skin tumors conveniently. Thus, the assembly strategy enables this hybrid bioplaster to hold great potential for skin-related tumor treatment.The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/adma.202110062.

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“…Recently, various functional hydrogels have been widely used to promote wound healing. [108][109][110][111][112][113][114][115][116][117][118] Chang and coworkers developed a unique bioglass (BG)/oxidized sodium alginate (OSA) composite hydrogel that showed excellent bioactivity to promote vascularization and accelerate tissue regeneration. 119 On the one hand, the BG improves the tissue bonding strength by providing an alkaline microenvironment to stimulate bond formation between the OSA and the amino groups on the surrounding tissue.…”

Section: Wound Healingmentioning

confidence: 99%

Mechanisms and applications of bioinspired underwater/wet adhesives

Cai

Жен

Chen

et al. 2021

Journal of Polymer Science

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In nature, many organisms can effectively fix to contact substrates and move and prey in complex living environments, such as underwater, seawater, and tidal environments, owing to special secreted chemical components and/or special micro/nanostructures on the adhesive surface of these organisms.Inspired by the adhesive performance of organisms, extensive research related to adhesive components and adhesive surfaces has been conducted recently.To better understand the underlying adhesive mechanisms and facilitate further continuous inspiration, a brief overview of recent wet/underwater adhesive materials is provided herein. First, the adhesive processes and underlying mechanisms of commonly researched organisms, such as mussels, octopuses, clingfish, and tree frogs, are discussed, and the corresponding bioinspired artificial adhesives are presented. Then, the applications of these bioinspired adhesives, such as intelligent robots (signal monitoring and sensing devices), wearable devices (including wet climbing and electronic skin), biomedicines (including wound dressings, bone adhesion, and rapid hemostasis), are presented and summarized. Finally, we offer our perspective on the future challenges and development of bioinspired artificial adhesives. K E Y W O R D S adhesive surfaces, applications, artificial components, natural organisms 1 | INTRODUCTION Recently, the development of wet/underwater adhesives inspired by natural organisms has attracted increasing attention and achieved significant progress based on various Chao Cai and Zhen Chen contributed equally to this work

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Genetically Engineered Polypeptide Adhesive Coacervates for Surgical Applications

Cited by 95 publications

References 53 publications

Self‐Assembling Peptide‐Based Hydrogels for Wound Tissue Repair

Self‐Assembling Peptide‐Based Hydrogels for Wound Tissue Repair

An Engineered Protein−Au Bioplaster for Efficient Skin Tumor Therapy

Mechanisms and applications of bioinspired underwater/wet adhesives

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