Genome and stress-reaction in animals and humans

Abstract

Current data on the effects of stress at the level of the cell genomes of the central nervous system and peripheral organs in animals are discussed. Regulatory and structural genomic changes in the cells of the central nervous system under stress are considered as a mechanism for regulating the functions of the brain and peripheral organs that form the organism manifestations of stress. Based on the Yu.Ya. Kerkis and M.E. Lobashev point of view, we consider stress as a special physiological state of the nervous system, affecting the work and integrity of the genome in target cells in animals, and thus playing a major role in microevolutionary transformations.

Effects of psychogenic stress on some peripheral and central inflammatory markers in rats with the different level of excitability of the nervous system

“…The genetically determined level of excitability of the nervous system also affects epigenetic milieu that have different dynamics in the brain areas associated with emotions. Therefore, low and high levels of excitability can be considered as risk factors for the development of post-stress pathologies such as PTSD and compulsive disorders [15]. The study of the influence of the genetically determined level of nervous system excitability on the development of immune dysfunctions in response to stressors can help us to understand the nature of individual differences in the pathogenesis of post-stress mental disorders.…”

Disadaptive genetic-evolutionary processes in human populations of industrial cities

“…Анализ показал, что деятельность генома человека находится под контролем системной (нейроэндокринной) регуляции генетических процессов [6]. Но все же экстремальное действие стрессора индуцирует перестройку генетического материала клетки, вплоть до его полной дезинтеграции, что в конечном счете, приводит к невозможности человека адаптироваться к условиям внешним среды.…”