Genome-wide integrated analysis reveals functions of lncRNA-miRNA-mRNA interactions in Atlantic salmon challenged by Aeromonas salmonicida

Xia, Yuqing; Cheng, Jianxin; Liu, Ya‐fang; Li, Chenghua; Liu, Ying; Liu, Pengfei

doi:10.1016/j.ygeno.2021.12.013

Cited by 11 publications

(7 citation statements)

References 65 publications

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“…However, a wide infection caused by A. salmonicida has been reported in different species of fish worldwide, including rainbow trout ( Oncorhynchus mykiss ), Atlantic salmon ( Salmo salar ), arctic char ( Salvelinus alpinus ), brook trout ( Salvelinus fontinalis ), brown trout ( Salmo trutta ), carp ( Cyprinus carpio ), goldfish ( Carassius auratus ), orange‐spotted grouper ( Epinephelus coioiaes ) and sablefish ( Anoplopoma fimbria ) from Canada, USA, Switzerland, Norway, France, South Korea, Spain, Chile, China and so on (Bartkova et al, 2010; Charette et al, 2012; Evenberg et al, 1986; Huang, Qi, Zuo, Alias, & Xu, 2020; Humphrey & Ashburner, 1993; Pylkkö et al, 2005; Valderrama et al, 2019; Vasquez et al, 2020). In particular, it is worth noting that, more and more studies in China on infection (Lian et al, 2020; Meng et al, 2020; Wang et al, 2020), pathogenicity (Chen et al, 2022; Meng et al, 2017; Yi et al, 2022) and interaction with hosts of A. salmonicida (Huang, Qi, Zuo, Alias, & Xu, 2020; Long et al, 2015; Xia et al, 2022; Xue et al, 2021) have been reported in recent years, implying the popularity and importance of this bacterium in China.…”

Section: Introductionmentioning

confidence: 99%

Comparative genomic analysis provides insights into taxonomy and temperature adaption of Aeromonas salmonicida

Long

Fan

Gan

et al. 2023

Journal of Fish Diseases

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Aeromonas salmonicida is an important pathogen to both freshwater and marine fish in aquaculture (Dallaire-Dufresne et al., 2014).There are five subspecies reported so far: salmonicida, smithia, achromogenes, masoucida and pectinolytica (Cipriano & Bullock, 2001;Garrity et al., 2005). Initially, A. salmonicida is popular and often reported in areas with a relatively low average atmospheric temperature, for example, Canada (Morin, 2010), European countries (Bartkova et al., 2017), etc. However, a wide infection caused by A. salmonicida has been reported in different species of fish worldwide, including rainbow trout (Oncorhynchus mykiss), Atlantic salmon (Salmo salar), arctic char (Salvelinus alpinus), brook trout (Salvelinus fontinalis), brown trout (Salmo trutta), carp (Cyprinus carpio), goldfish (Carassius auratus), orange-spotted grouper (Epinephelus coioiaes) and sablefish (Anoplopoma fimbria) from

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Section: Introductionmentioning

confidence: 99%

Comparative genomic analysis provides insights into taxonomy and temperature adaption of Aeromonas salmonicida

Long

Fan

Gan

et al. 2023

Journal of Fish Diseases

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“…Some studies have used microarrays or high-throughput RNA sequencing (RNA-Seq) to understand the effects of A. salmonicida subsp. salmonicida infection in fish, including rainbow trout (Rebl et al, 2014;Long et al, 2015;Ji et al, 2020), Atlantic salmon (Ewart et al, 2005;Xia et al, 2022) and turbot (Millań et al, 2011). Millań et al (2011), using an immuneenriched oligo-microarray, partially characterized the transcriptome response of different tissues (spleen, liver and head kidney) from turbot to infection with A. salmonicida.…”

Section: Discussionmentioning

confidence: 99%

Transcriptome Analysis of Turbot (Scophthalmus maximus) Infected With Aeromonas salmonicida Reveals a Direct Effect on Leptin Synthesis as a Neuroendocrine Mediator of Inflammation and Metabolism Regulation

Librán-Pérez

Pereiro²,

Figueras³

et al. 2022

Front. Mar. Sci.

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Aeromonas salmonicida subsp. salmonicida is the causative agent of furunculosis, a disease affecting numerous fish species worldwide. It is a highly pathogenic bacterium for turbot, whose farming production represents an important economic activity in several European countries and China. To better understand the response of this organism to A. salmonicida, we conducted RNA-Seq analysis of the head kidney from experimentally infected and uninfected turbot juveniles at 24 hours post-infection (hpi). As expected, among the differentially expressed genes (DEGs) between infected and uninfected fish, we observed the modulation of a multitude of immune-related genes but also a high representation of genes linked to metabolism. Interestingly, one of the most upregulated genes was that encoding the hormone leptin. Leptin is a multifunctional hormone/cytokine that has been shown to play roles in the immune system, stress response, food intake, metabolism and energy balance. We used recombinant human leptin to elucidate its role during infection with A. salmonicida in turbot (anorexigenic activity, ability to modulate metabolism and the immune response, and its effect on survival and bacterial load during infection). We found that the intraperitoneal administration of leptin was able to alter the response to the bacteria at the immune level, but especially at the metabolic level, which resulted in a higher survival rate without affecting the bacterial load. Based on this, we hypothesized that leptin could offer great potential as a therapeutic treatment during furunculosis outbreaks by reducing the impact of sepsis. Our results reveal the complex interplay between bacterial activity and the regulation of food intake, metabolism and inflammation.

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“…Based on the identified lncRNAs, miRNAs, and mRNAs that were differentially expressed in gills of Atlantic salmon ( Salmo salar , S. salar ) infected with A. salmonicida , an immune-related lncRNA-miRNA-mRNA ceRNA network was constructed ( 72 ). This network includes 32 lncRNAs, 10 miRNAs, and 16 mRNAs, which are associated with many immune-related signaling pathways, such as p53, (Wnt)/β-chain protein (β-catenin), mammalian target of rapamycin (mTOR), Janus kinase (JAK)/signal transducer and activators of transcription (STAT), and Toll-like receptor (TLR).…”

Section: The Regulatory Roles Of the Lncrna-mirna-mrna Axis In Teleos...mentioning

confidence: 99%

The potential regulatory role of the lncRNA-miRNA-mRNA axis in teleost fish

Zhou

Leng²,

Wang³

et al. 2023

Front. Immunol.

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Research over the past two decades has confirmed that noncoding RNAs (ncRNAs), which are abundant in cells from yeast to vertebrates, are no longer “junk” transcripts but functional regulators that can mediate various cellular and physiological processes. The dysregulation of ncRNAs is closely related to the imbalance of cellular homeostasis and the occurrence and development of various diseases. In mammals, ncRNAs, such as long noncoding RNAs (lncRNAs) and microRNAs (miRNAs), have been shown to serve as biomarkers and intervention targets in growth, development, immunity, and disease progression. The regulatory functions of lncRNAs on gene expression are usually mediated by crosstalk with miRNAs. The most predominant mode of lncRNA-miRNA crosstalk is the lncRNA-miRNA-mRNA axis, in which lncRNAs act as competing endogenous RNAs (ceRNAs). Compared to mammals, little attention has been given to the role and mechanism of the lncRNA-miRNA-mRNA axis in teleost species. In this review, we provide current knowledge about the teleost lncRNA-miRNA-mRNA axis, focusing on its physiological and pathological regulation in growth and development, reproduction, skeletal muscle, immunity to bacterial and viral infections, and other stress-related immune responses. Herein, we also explored the potential application of the lncRNA-miRNA-mRNA axis in the aquaculture industry. These findings contribute to an enhanced understanding of ncRNA and ncRNA-ncRNA crosstalk in fish biology to improve aquaculture productivity, fish health and quality.

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Genome-wide integrated analysis reveals functions of lncRNA-miRNA-mRNA interactions in Atlantic salmon challenged by Aeromonas salmonicida

Cited by 11 publications

References 65 publications

Comparative genomic analysis provides insights into taxonomy and temperature adaption of Aeromonas salmonicida

Comparative genomic analysis provides insights into taxonomy and temperature adaption of Aeromonas salmonicida

Transcriptome Analysis of Turbot (Scophthalmus maximus) Infected With Aeromonas salmonicida Reveals a Direct Effect on Leptin Synthesis as a Neuroendocrine Mediator of Inflammation and Metabolism Regulation

The potential regulatory role of the lncRNA-miRNA-mRNA axis in teleost fish

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