Genotypic Variation in the Transforming Growth Factor-??1 Gene

Awad, Mohammed; El‐Gamel, Adam; Hasleton, Philip; Turner, David M.; Sinnott, Paul J.; Hutchinson, Ian V.

doi:10.1097/00007890-199810270-00009

Cited by 586 publications

(144 citation statements)

References 23 publications

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“…We hypothesized that the increased frequency of hyperexpression of TGF-␤ 1 may contribute to the excess burden of ESRD in blacks. We also have suggested that hyperexpression of TGF-␤ 1 might be genetically determined, because DNA polymorphisms in codon 25 of the TGF-␤ 1 gene have been associated with hypertension (20) and codon 10 polymorphisms have been associated with lung fibrosis (21).…”

mentioning

confidence: 99%

Transforming growth factor-beta 1 hyperexpression in African-American hypertensives: A novel mediator of hypertension and/or target organ damage

Suthanthiran

Li²,

Song³

et al. 2000

Proceedings of the National Academy of Sciences

192

126

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Hypertension, a remediable risk factor for stroke, cardiovascular disease, and renal failure, affects 50 million individuals in the United States alone. African Americans (blacks) have a higher incidence and prevalence of hypertension and hypertension-associated target organ damage compared with Caucasian Americans (whites). Herein, we explored the hypotheses that transforming growth factor-␤1 (TGF-␤1) is hyperexpressed in hypertensives compared with normotensives and that TGF-␤1 overexpression is more frequent in blacks compared with whites. These hypotheses were stimulated by our recent demonstration that TGF-␤1 is hyperexpressed in blacks with end-stage renal disease compared with white end-stage renal disease patients and by the biological attributes of TGF-␤1, which include induction of endothelin-1 expression, stimulation of renin release, and promotion of vascular and renal disease when TGF-␤ 1 is produced in excess. TGF-␤1 profiles were determined in black and white hypertensive subjects and normotensive controls and included circulating protein concentrations, mRNA steady-state levels, and codon 10 genotype. Our investigation demonstrated that TGF-␤1 protein levels are highest in black hypertensives, and TGF-␤1 protein as well as TGF-␤1 mRNA levels are higher in hypertensives compared with normotensives. The proline allele at codon 10 (Pro 10 ) was more frequent in blacks compared with whites, and its presence was associated with higher levels of TGF-␤1 mRNA and protein. Our findings support the idea that TGF-␤ 1 hyperexpression is a risk factor for hypertension and hypertensive complications and provides a mechanism for the excess burden of hypertension in blacks.

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mentioning

confidence: 99%

Transforming growth factor-beta 1 hyperexpression in African-American hypertensives: A novel mediator of hypertension and/or target organ damage

Suthanthiran

Li²,

Song³

et al. 2000

Proceedings of the National Academy of Sciences

192

126

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“…Some of these polymorphisms seem to be correlated to its production [18][19][20][21][22][23][24][25], and potentially conferring flexibility to immune response. The presence of certain genotypes may influence the course of both viral and bacterial infections [13,[26][27][28][29], as well as be associated to susceptibility or resistance to auto-immune diseases [30,31], or influence both solid organ post-transplant rejection processes [32,33], and graft versus host disease post bone-marrow transplantation [34,35].…”

Section: Discussionmentioning

confidence: 99%

The Possible Protective Role of the Il6-174GC Genotype in Dengue Fever

Moreira¹,

Cardoso²,

Visentainer³

et al. 2008

TOTMJ

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Dengue is the most important viral disease transmitted by arthropod vectors. At present, it is known four types of virus serotypes, DEN 1, 2, 3 and 4. Differences in the host susceptibility to infection as well as the severity of disease can not be due only to viral virulence. Variations in immune response as a consequence of polymorphisms in regulatory regions of cytokine genes may have influence on the disease outcome. The aim of this study was to verify the occurrence of associations between cytokine gene polymorphisms and Dengue Fever.

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“…Polymorphisms in the regulatory regions of several cytokine genes may cause inter-individual differences in cytokine production (Wilson et al, 1997;Turner et al, 1997;Awad et al, 1998;Fishman et al, 1998;Pravica et al, 1999). As these polymorphisms segregate independently, each person is a mosaic of high-, intermediate-, and low-producing phenotypes.…”

Section: Cytokine Gene Polymorphismsmentioning

confidence: 99%

Importance of Non-HLA Gene Polymorphisms in Hematopoietic Stem Cell Transplantation

Visentainer¹,

Sell²

2012

New Advances in Stem Cell Transplantation

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Genotypic Variation in the Transforming Growth Factor-??1 Gene

Abstract: The production of TGF-beta1 is under genetic control, and this in turn influences the development of lung fibrosis. Hence, the TGF-beta1 genotype has prognostic significance in transplant recipients.

Cited by 586 publications

References 23 publications

Transforming growth factor-beta 1 hyperexpression in African-American hypertensives: A novel mediator of hypertension and/or target organ damage

Transforming growth factor-beta 1 hyperexpression in African-American hypertensives: A novel mediator of hypertension and/or target organ damage

The Possible Protective Role of the Il6-174GC Genotype in Dengue Fever

Importance of Non-HLA Gene Polymorphisms in Hematopoietic Stem Cell Transplantation

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