Giant Cell Tumor (Osteoclastoma) of the Mandible: A Diagnostic Dilemma and a Therapeutic Challenge

Tumor de células gigantes mandibular

“…Giant cell tumor is defined as a primary benign neoplasm of the bone that is locally aggressive. 1,[3][4][5][6] It was first described by Sir Astley Cooper en 1818. 6 1,4,6 It more commonly affects women between the 2 nd and 3 rd decades in life.…”

“…1,[3][4][5][6] It was first described by Sir Astley Cooper en 1818. 6 1,4,6 It more commonly affects women between the 2 nd and 3 rd decades in life. 2,4,[5][6][7][8]13 Between 1 and 3% occur in children under the age of 14.…”

“…6 1,4,6 It more commonly affects women between the 2 nd and 3 rd decades in life. 2,4,[5][6][7][8]13 Between 1 and 3% occur in children under the age of 14. 6 It has a high prevalence in China and in Southern India (Andhra Pradesh State).…”

Primary Giant Cell Tumor of Soft Tissue in the Mental Region

“…The giant cell tumor (GCT), as previously defined the nature of the entity by Jaffe et al 1) , is generally benign neoplasm but has propensity for recurrence [2][3][4] , malignant transformation 5,6) or distant metastasis 7,8) because of its aggressive clinical behavior. As previously reported 5) , approximately 80-90 % cases of GCT have been occurred in the extremities, especially in the lower extremities 1) .…”

“…In the oral and maxillofacial region, not frequent site for GCT, most cases affect the mandible and maxilla 2,11,12) and some cases located in the salivary gland [13][14][15][16][17][18][19][20][21][22][23][24] or nasal cavity 25) have been reported as primary soft tissue analogue in this region. Despite the majority of GCT in the oral and maxillofacial region are histologically comprised of an abundance of multinucleate giant cells and homogeneous population of round to polygonal mononuclear cells in the background 11) with poor cellular atypia and mitotic figures, some of them have revealed a carcinomatous component [13][14][15][17][18][19][20][22][23][24] , local recurrence 2,3) or malignant transformation like those in the extremities. Here we report a case of 37-year old woman with a well-defined mental subcutaneous giant cell tumor rapidly growing over the mandibular gingivae and mandibular intraosseous tissue.…”