Giant condyloma acuminatum of the vulva: Successful management with imiquimod

Combaud, Vanessa; Verhaeghe, Caroline; Hachem, Hady El; Legendre, Guillaume; Descamps, Philippe; Martin, Ludovic; Bouet, Pierre‐Emmanuel

doi:10.1016/j.jdcr.2018.04.007

Cited by 17 publications

(24 citation statements)

References 4 publications

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“…Although imiquimod has been used in the past for treatment of BLT, excepting one case, that too of a vulvar BLT in a young woman, it was always combined with another modality (Table 1). 5–10 We successfully treated our patient, a noncandidate for surgery and oral retinoids, with 16 weeks of monotherapy with imiquimod resulting in complete lesional clearance and at least five-year relapse-free period. Although combination therapy remains the mainstay of treatment of BLT, standalone treatment with imiquimod may be attempted in a special case scenario.…”

Section: Discussionmentioning

confidence: 99%

Successful nonsurgical treatment of penile Buschke–Löwenstein tumor with 12 weeks of 5% imiquimod alone

Sonthalia¹,

Gandhi

Agrawal

et al. 2019

Int J STD AIDS

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Anogenital warts, also known as condylomata acuminata caused by human papillomavirus constitute the most common sexually transmitted infection. Rarely, the disease may evolve into a huge cauliflower-like growth called giant condyloma acuminatum or Buschke–Löwenstein tumor (BLT). In contrast with normal anogenital warts, BLT displays local invasion, lack of spontaneous resolution, posttreatment recurrence, and potential for malignant transformation. Although radical excision with split-thickness skin grafting is considered its first-line treatment, it is not always feasible. While many other treatments have shown variable success and recurrence rates, topical imiquimod 5%, a popular evidence-based therapy for warts has also been reported as an efficacious treatment for BLT. We present a case of penile BLT where the patient refused surgery but recovered completely with no recurrence at five years following 16 weeks’ therapy with topical 5% imiquimod. Excepting a single reported case, this might be another case where BLT resolved with imiquimod as a standalone therapy. We also present a succinct review of past cases of BLT treated with imiquimod.

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Section: Discussionmentioning

confidence: 99%

Successful nonsurgical treatment of penile Buschke–Löwenstein tumor with 12 weeks of 5% imiquimod alone

Sonthalia¹,

Gandhi

Agrawal

et al. 2019

Int J STD AIDS

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“…It is rare, the reported incidence being 0.1% in the general population. 1 GCA can present as a cauliflower-like lesion 2 with broad-based papillomas up to several centimeters in diameter or as large confluent plaques. These lesions mostly occur in the perineum, vulva, vagina, perianal region and rectum, 3 rarely developing in extragenital areas.…”

Section: Introductionmentioning

confidence: 99%

“…6 Radical surgery alone or combined with other treatment modalities such as chemotherapy or photodynamic therapy [6][7][8] has been recommended; however, this can have undesirable sequelae, such as scarring and poor functional and esthetic outcomes. 1 Some recently published studies have reported satisfactory outcomes after topical use of drugs, such as imiquimod, interferon, and the traditional Chinese medicine (TCM) preparation, paiteling. 1,[9][10][11] TCM preparations may be effective adjuncts to, or replacements for, mainstream medicines for GCA because they contain numerous ingredients and therefore probably have multiple mechanisms of action.…”

Section: Introductionmentioning

confidence: 99%

“…1 Some recently published studies have reported satisfactory outcomes after topical use of drugs, such as imiquimod, interferon, and the traditional Chinese medicine (TCM) preparation, paiteling. 1,[9][10][11] TCM preparations may be effective adjuncts to, or replacements for, mainstream medicines for GCA because they contain numerous ingredients and therefore probably have multiple mechanisms of action. Chinese researchers have reported that paiteling is effective in eradicating lesions, achieving better cosmetic outcomes, and improving quality of life.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy and Safety of Giant Condyloma Acuminatum with Monotherapy of Topical Traditional Chinese Medicine: Report of Eight Cases

Wang¹,

Li²,

Li³

2021

IDR

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Background: Giant condyloma acuminatum (GCA), also called Buschke-Löwenstein tumor, presents as a verrucous infiltrating lesion and is caused by sexual transmission of human papilloma virus. The optimal treatment is controversial and there are no standard guidelines because of its rarity and frequent recurrence. It has a relatively high local recurrence rate. Objective: We here report eight patients (six men and two women) with GCA whose lesions were successfully treated topically with traditional Chinese medicine (TCM) preparations, paiteling. Methods and Materials: We administered topical TCM preparations to eight patients diagnosed with GCA who had refused surgery. The treatment process included three stages, their durations depending on the speed of resolution of the lesions and the results of visual inspection with acetic acid. Results: No significant complications occurred in any patient. The functional and esthetic outcomes were satisfactory. No recurrences were detected during follow-up. Conclusion:Topical treatment with TCM preparations may be a good alternative to surgery or other traditional methods for the treatment of GCA. This treatment has the advantages of being non-invasive, painless, and having a low risk of recurrence, and may be a useful adjunct to mainstream medical treatments.

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“…Recently, a nonsurgical alternative especially topical imiquimod as monotherapy has been shown as an efficacious and tissue-preserving treatment for select cases of Bushke Lowenstein tumor (Combaud, Verhaeghe, El Hachem, et al, 2018;Sonthalia et al, 2019).…”

mentioning

confidence: 99%

“Giant Condyloma Acuminatum (Buschke–Lowenstein tumor): Combined treatment with surgery and chemotherapy.”—Further points to be discussed

Gómez¹

2020

Dermatologic Therapy

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Giant condyloma acuminatum of the vulva: Successful management with imiquimod

Cited by 17 publications

References 4 publications

Successful nonsurgical treatment of penile Buschke–Löwenstein tumor with 12 weeks of 5% imiquimod alone

Successful nonsurgical treatment of penile Buschke–Löwenstein tumor with 12 weeks of 5% imiquimod alone

Efficacy and Safety of Giant Condyloma Acuminatum with Monotherapy of Topical Traditional Chinese Medicine: Report of Eight Cases

“Giant Condyloma Acuminatum (Buschke–Lowenstein tumor): Combined treatment with surgery and chemotherapy.”—Further points to be discussed

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