Global frequency and distribution of head and neck cancer in pediatrics, a systematic review

Arboleda, Lady Paola Aristizábal; Mendonça, Regina Maria Holanda de; Lopez, Eliana Elisa Muñoz; Araujo, André; Palmier, Natália Rangel; Paglioni, Mariana de Pauli; Fonsêca, Jéssica Montenegro; Hoffmann, Iva Loureiro; Cardinalli, Izilda Aparecida; Chaves, Aline Lauda Freitas; Aranda, Saray; Brandão, Thaís Bianca; Lopes, Márcio Ajudarte; Ribeiro, Ana Carolina Prado; Troconis, Cristhian Camilo Madrid; Santos‐Silva, Alan Roger

doi:10.1016/j.critrevonc.2020.102892

Cited by 26 publications

(38 citation statements)

References 27 publications

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“…Interestingly, among children, males over 10 years of age are more affected by lymphomas, followed by carcinomas and sarcomas regarding head and neck malignant tumours. 23 In our series, mantle cell lymphoma (MCL), plasmablastic lymphoma (PBL), Burkitt's lymphoma (BL), and B-ALL/LBL, NOS, also affected infants. According to Triantafillidou et al, 24 MCL of the oral cavity occurs in middle-aged to older individuals, with a mean age of 55.7 years and no involvement of children or adolescents; however, we found three cases affecting paediatric patients.…”

Section: Discussionmentioning

confidence: 66%

“…25 In addition, it is well recognized that there is a high incidence of BL in childhood, particularly in the scenario of its endemic variant on the African continent. 23 Conversely, B-ALL/LBL is exceedingly rare in the oral cavity, although children and adolescents are frequently affected by this disease. 26 In our study, most individuals were in the seventh and sixth decades of life, in agreement with a multicentre study from Iran, in which most affected individuals were males in their 50s and 60s.…”

Section: Discussionmentioning

confidence: 99%

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Oral and oropharyngeal lymphomas: A multi‐institutional collaborative study

Arruda

Schuch

Neto

et al. 2021

J Oral Pathology Medicine

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Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Oral and oropharyngeal lymphomas: A multi‐institutional collaborative study

Arruda

Schuch

Neto

et al. 2021

J Oral Pathology Medicine

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“…Taking this into consideration, we rationalized that comparing results from leukemia datasets with those from solid tumors would not be feasible. We considered thyroid cancer as part of the head/neck category since it is often treated as part of this class in the medical field and in the scientific literature (Arboleda et al, 2020). No cancer derived from skin and uterine cancers fitted the entire filtering criteria (i.e., from dataset filtering to preprocessing steps) for microarray datasets, whereas no datasets for bone, bladder, pancreatic, brain, gastric, and ovarian cancers could be selected for RNA-seq.…”

Section: Data Gathering Differential Expression and Feature Selectionmentioning

confidence: 99%

Multi-Approach Bioinformatics Analysis of Curated Omics Data Provides a Gene Expression Panorama for Multiple Cancer Types

et al. 2020

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Studies describing the expression patterns and biomarkers for the tumoral process increase in number every year. The availability of new datasets, although essential, also creates a confusing landscape where common or critical mechanisms are obscured amidst the divergent and heterogeneous nature of such results. In this work, we manually curated the Gene Expression Omnibus using rigorous filtering criteria to select the most homogeneous and highest quality microarray and RNA-seq datasets from multiple types of cancer. By applying systems biology approaches, combined with machine learning analysis, we investigated possible frequently deregulated molecular mechanisms underlying the tumoral process. Our multi-approach analysis of 99 curated datasets, composed of 5,406 samples, revealed 47 differentially expressed genes in all analyzed cancer types, which were all in agreement with the validation using TCGA data. Results suggest that the tumoral process is more related to the overexpression of core deregulated machinery than the underexpression of a given gene set. Additionally, we identified gene expression similarities between different cancer types not described before and performed an overall survival analysis using 20 cancer types. Finally, we were able to suggest a core regulatory mechanism that could be frequently deregulated.

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“…NHL is also common in adults, but with only 5.6% comprising Burkitt lymphoma in the head and neck (BLHN) region. [1][2][3][4] BL was first described by Dennis Burkitt in 1958 as a sarcoma involving the jaws of African children. In 2017, it was defined by the World Health Organization (WHO) classification as a highly aggressive NHL composed of monomorphic intermediate-sized B cells with basophilic cytoplasm and numerous mitotic figures.…”

Section: Introductionmentioning

confidence: 99%

Burkitt lymphoma of the head and neck: An international collaborative study

Arboleda

Rodrigues-Fernandes

Mariz

et al. 2021

J Oral Pathology Medicine

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Background: Burkitt lymphoma (BL) is an aggressive B-cell lymphoma with three variants (endemic, sporadic, and immunodeficiency-associated), presenting with specific epidemiological and clinical features. Burkitt lymphoma affects the head and neck region (BLHN) in approximately 10% of cases. The aim of this study was to undertake a comparative analysis of the clinicopathologic and immunohistochemical (IHC) features of BLHN diagnosed in patients from Africa, Guatemala, and Brazil. Methods: Cases diagnosed as BLHN were collected from the files of six oral pathology laboratory services (Brazil, South Africa, and Guatemala) and one Brazilian pediatric oncology hospital from 1986 to 2020. Clinicopathological and IHC data, and Epstein-Barr virus (EBV) status by in situ hybridization data for each case were reviewed and described. Results: Of the 52 cases, BLHN was predominant in pediatric patients [43 (82.69%)] and males [43 (82.69%)], with a mean age of 11.26 ± 9.68 years (range, 1-39 years). Neck and cervical lymph nodes [14 (26.92%)], and involvement of both maxilla and mandible [8 (15.38%)], were the most common anatomical sites. Clinically, tumor/ swelling [40 (31.25%)], cervical lymphadenopathy [14 (10.94%)], pain [12 (9.38%)], and bone destruction [12 (9.38%)] were frequent findings. All cases showed typical morphological characteristics of BL. IHC profiles included positivity for CD20 [52 (100%)], CD10 [38 (79.17%)], Bcl6 [29 (87.88%)], and c-Myc protein [18 (81.82%)]. EBV was positive in 18 cases (62.07%). The Ki-67 index ranged from 90 to 100%. Special issue "Lymphomas and lymphoid lesions of the oral cavity".| 573 ARBOLEDA Et AL.

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Global frequency and distribution of head and neck cancer in pediatrics, a systematic review

Cited by 26 publications

References 27 publications

Oral and oropharyngeal lymphomas: A multi‐institutional collaborative study

Oral and oropharyngeal lymphomas: A multi‐institutional collaborative study

Multi-Approach Bioinformatics Analysis of Curated Omics Data Provides a Gene Expression Panorama for Multiple Cancer Types

Burkitt lymphoma of the head and neck: An international collaborative study

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