2011
DOI: 10.1523/jneurosci.3869-10.2011
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GluA2 (GluR2) Regulates Metabotropic Glutamate Receptor-Dependent Long-Term Depression through N-Cadherin-Dependent and Cofilin-Mediated Actin Reorganization

Abstract: The GluA2 (GluR2) subunit is critical for the regulation of AMPA receptor properties and synaptic plasticity, but the underlying mechanisms remain unclear. Here, we demonstrate that GluA2 regulates metabotropic glutamate receptor-dependent long-term depression (mGluR-LTD) through a previously unknown mechanism involving N-cadherin-dependent and cofilin-mediated actin reorganization. We show that GluA2 is indispensable for mGluR-LTD in the hippocampus, and surprisingly this action of GluA2 is mediated by its ex… Show more

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Cited by 79 publications
(91 citation statements)
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“…N-cadherin has been shown to critically stabilize the pre-and postsynaptic connection, both in synaptogenesis and during activity-dependent growth of synaptic contacts (6). In agreement with AMPARs and N-cadherin being involved in functional and structural synaptic plasticity, an interaction between their extracellular domains at the surface membrane was reported (7,8) that stimulates presynaptic development and dendritic spine formation.…”
mentioning
confidence: 79%
“…N-cadherin has been shown to critically stabilize the pre-and postsynaptic connection, both in synaptogenesis and during activity-dependent growth of synaptic contacts (6). In agreement with AMPARs and N-cadherin being involved in functional and structural synaptic plasticity, an interaction between their extracellular domains at the surface membrane was reported (7,8) that stimulates presynaptic development and dendritic spine formation.…”
mentioning
confidence: 79%
“…In particular, cofilin is indispensable for the expression of hippocampal LTD and associated spine plasticity (Zhou et al, 2004;Rust et al, 2010;Zhou et al, 2011;Eales et al, 2014). However, whether the involvement of cofilin in LTD is regulated by developmental stages remains unknown.…”
Section: Discussionmentioning
confidence: 99%
“…Electrophysiological recordings were conducted at the Schaffer/Collateral pathway in the hippocampus as previously described (Meng et al, 2002(Meng et al, , 2003Zhou et al, 2011). Briefly, the mouse brains of either sex were quickly removed and sagittal 300-400 µm hippocampal slices prepared in ice-cold artificial cerebrospinal fluid (ACSF) saturated with 95% O2/5% CO2.…”
Section: Electrophysiologymentioning
confidence: 99%
“…Cadherins form both direct and indirect associations with AMPA receptors (31)(32)(33), and stabilizing β-catenin/ cadherin interactions in vitro has been shown to prevent the internalization of both cadherin and AMPA receptors during conditions that induce LTD (5). Interestingly, mGluR-dependent LTD has also been shown to require interaction between N-cadherin and the GluR2 subunit of AMPA receptors, providing further evidence of an important functional relationship between cadherin and AMPA receptors at synapses (33). Because LTD is achieved through removal of AMPA receptors from the postsynaptic membrane (34), the physiological impairment in LTD observed in β-cat Δex3/+ mice is consistent with the deficits in AMPA receptor endocytosis observed by immunogold electron microscopy.…”
Section: Discussionmentioning
confidence: 99%