1959
DOI: 10.1152/jappl.1959.14.6.1026
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Glucose biokinetics in normal and ketotic cows

Abstract: The size, turnover time and transfer rate of the glucose pool were estimated with glucose–C14 in normal and ketotic cows. The size and turnover time of the pool were both about 1/5 greater in the ketotic than in the normal cows, so that the transfer rate remained similar, being about 1 gm/min. The hypoglycemia which is characteristic of the disease appeared to be associated with an expansion of the glucose space, which in the normal cows approximated the extracellular volume, into the intracellular compartment… Show more

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Cited by 24 publications
(3 citation statements)
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“…When the values of glucose space for the young lambs were calculated with allowance for the erythrocyte volume and glucose content, values 10-15 % lower than those shown in Tables 1 and 2 were obtained. Kronfeld, Tombropoulos & Kleiber (1959) reported that the glucose space in ketotic cows was between 54 % and 80 % of body weight, and considered that this could be attributed to an expansion of the glucose space into the intracellular 'compartment'.…”
Section: Discussionmentioning
confidence: 99%
“…When the values of glucose space for the young lambs were calculated with allowance for the erythrocyte volume and glucose content, values 10-15 % lower than those shown in Tables 1 and 2 were obtained. Kronfeld, Tombropoulos & Kleiber (1959) reported that the glucose space in ketotic cows was between 54 % and 80 % of body weight, and considered that this could be attributed to an expansion of the glucose space into the intracellular 'compartment'.…”
Section: Discussionmentioning
confidence: 99%
“…Isotope-dilution techniques, which provide the only satisfactory methods for the measurement of turnover rates in the intact animal, have been used to determine glucose-utilization rates in rats (Feller, Strisower & Chaikoff, 1950;Baker, Shipley, Clark & Incefy, 1959), man (Baker, Shreeve, Shipley, Incefy & Miller: 1954) and dogs (Searle, Strisower & Chaikoff, 1954;Steele, Wall, de Bodo & Altszuler, 1956). Studies of ruminants, however, have been limited to those of Baxter, Kleiber & Black (1955) and Kronfeld, Tombropoulos & Kleiber (1959), who used single-injection procedures to measure glucose-turnover rates in cows. In the present investigation glucose-utilization rates in fed and starved sheep have been determined by isotope dilution with the constantinfusion method of Steele et al (1956).…”
mentioning
confidence: 99%
“…(1964). and Kronfeld et al (1959). The rate of net formation, or irreversible loss, of glucose was estimated from the integration of an exponential equation as described by White et al (1969).…”
Section: Methods Of Calculationmentioning
confidence: 99%