Glucose intolerance during prolonged sevoflurane anaesthesia

Iwasaka, Hideo; Itoh, Kouji; Miyakawa, Hiroshi; Kitano, Takaaki; Taniguchi, Kazuo; Honda, Natsuo

doi:10.1007/bf03011909

Cited by 26 publications

(21 citation statements)

References 5 publications

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“…However, in previous studies [5,6,14], nitrous oxide was used as an anesthetic. Nitrous oxide was used to prevent the patient from becoming awake, especially with 0.5 MAC of inhaled anesthetics.…”

Section: Discussionmentioning

confidence: 99%

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Insulin secretion and glucose utilization are impaired under general anesthesia with sevoflurane as well as isoflurane in a concentration-independent manner

2005

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Section: Discussionmentioning

confidence: 99%

“…Insulin secretion and glucose tolerance during sevoflurane anesthesia have been studied in pigs [4] and in humans during surgery [5]. In addition, studies in human subjects have shown that isofluranenitrous oxide anesthesia has dose-independent effects on insulin secretion [6].…”

mentioning

confidence: 99%

Insulin secretion and glucose utilization are impaired under general anesthesia with sevoflurane as well as isoflurane in a concentration-independent manner

2005

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“…Saho et al suggested that sevoflurane and nitrous oxide anesthesia do not alter carbohydrate metabolism in comparison with combinations of nitrous oxide and other fluorocarbon anesthetics [17]. However, sevoflurane has been reported to lower insulin excretion in patients under prolonged anesthesia [18]. It is possible that even 0.2 g·kg Ϫ1 ·h Ϫ1 of glucose would induce hyperglycemia during prolonged sevoflurane anesthesia.…”

Section: Discussionmentioning

confidence: 98%

What is the optimal dose of glucose administration during minor surgery under sevoflurane anesthesia?

Terajima

Ogawa

2000

Journal of Anesthesia

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“…12,13 Even though the duration of surgery was significantly shorter in the VH group, the transvaginal procedure was associated with a higher plasma glucose concentration further emphasizing the greater stress potential of this surgical approach.…”

Section: Statisticsmentioning

confidence: 99%

“…Since the choice of surgical technique was entirely left to the attending surgeon, selection bias cannot be excluded in this study. However, in order to minimize bias from factors with known or potential metabolic impact such as duration of surgery 12,13 and inflammatory disease, patients with an anticipated long duration of surgery (ovarian pathology, previously known dense adhesions, inaccessible uterus) or endometriosis were not admitted to the study protocol.…”

Section: Statisticsmentioning

confidence: 99%

Laparoscopic-assisted vaginal hysterectomy and the hyperglycemic response to surgery: an observational study

Lattermann

Schricker

Wachter

et al. 2001

Can J Anesth/J Can Anesth

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P Pu ur rp po os se e: : To test the hypothesis that laparoscopic-assisted vaginal hysterectomy (LAVH) attenuates the hyperglycemic response to surgery when compared to vaginal hysterectomy (VH).M Me et th ho od ds s: : Fourteen patients received either LAVH (n=7) or VH (n=7). Whole body glucose production was measured before and three hours after surgery using [6.6 2 H 2 ] glucose. Before, during and after the operation, plasma concentrations of glucose, insulin, glucagon, cortisol, epinephrine and norepinephrine were determined.R Re es su ul lt ts s: : Plasma glucose concentration increased in both groups during and after surgery showing a significantly higher value after VH than after LAVH (VH: 8.3 ± 1.4 mmol·L 1 ; LAVH: 6.6 ± 0.9 mmol·L 1 , P <0.05). The postoperative increase in glucose production was comparable in both groups. While plasma concentrations of insulin and glucagon remained unchanged, intra-and postoperative plasma cortisol concentrations were significantly higher in the VH group than in the LAVH group. Plasma catecholamine concentrations significantly increased after both types of surgery to the same extent.C Co on nc cl lu us si io on n: : In this observational study, LAVH appears to blunt the hyperglycemic and cortisol response to surgery when compared to VH.Objectif : Vérifier lhypothèse selon laquelle lhystérectomie vaginale avec assistance laparoscopique (HVAL), comparée à lhystérectomie vaginale (HV), diminue la réponse hyperglycémique à lintervention chirurgicale.Méthode : Quatorze patientes ont subi une HVAL (n = 7) ou un HV (n = 7). La production corporelle totale de glucose a été mesurée avant lopération et trois heures après au moyen de glucose [6,6 2 H 2 ]. Avant, pendant et après lopération, les concentrations plasmatiques de glucose, dinsuline, de glucagon, de cortisol, dépinéphrine et de norépinéphrine ont été déterminées.Résultats : La concentration plasmatique de glucose a augmenté chez les patientes des deux groupes pendant et après lopération, affichant une valeur significativement plus élevée après lHV quaprès lHVAL (VH : 8,3 ± 1,4 mmol·L 1 ; HVAL : 6,6 ± 0,9 mmol·L 1 , P <0,05). Laugmentation postopératoire de production de glucose était comparable dun groupe à lautre. Les concentrations dinsuline et de glucagon sont demeurées les mêmes, mais celles du cortisol peropératoire et postopératoire ont été significativement plus élevées chez les patientes du groupe HV comparé au groupe HVAL. Les concentrations de catécholamine ont augmenté de façon significative, et avec la même importance, après les deux types dopérations. Conclusion

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Glucose intolerance during prolonged sevoflurane anaesthesia

Abstract: Brief ReportGlucose intolerance during prolonged sevoflurane anaesthesia Purpose

Cited by 26 publications

References 5 publications

Insulin secretion and glucose utilization are impaired under general anesthesia with sevoflurane as well as isoflurane in a concentration-independent manner

Insulin secretion and glucose utilization are impaired under general anesthesia with sevoflurane as well as isoflurane in a concentration-independent manner

What is the optimal dose of glucose administration during minor surgery under sevoflurane anesthesia?

Laparoscopic-assisted vaginal hysterectomy and the hyperglycemic response to surgery: an observational study

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