Glucose Oxidase-Instructed Traceable Self-Oxygenation/Hyperthermia Dually Enhanced Cancer Starvation Therapy

He, Ting; Xu, Han; Zhang, Yifan; Yi, Shijian; Cui, Run; Xing, Shaojun; Wei, Chaoliang; Lin, Jing; Huang, Peng

doi:10.7150/thno.40439

Cited by 144 publications

(74 citation statements)

References 46 publications

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“…[ 123 ] The process is known as GOx‐based starvation therapy and owing to its inherent biosecurity has attracted increasing interest in cancer management. [ 124 ] Nevertheless, because of the continuous consumption of O 2 molecules and nutrients during the procedure, it is difficult to eliminate tumors by relying on GOx alone. On this account, it is highly desirable to combine GOx with other therapies to improve therapeutic efficacy.…”

Section: Sonodynamic Therapy Combined With Other Treatmentsmentioning

confidence: 99%

Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

et al. 2020

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Ultrasound (US)-triggered sonodynamic therapy (SDT), as a promising noninvasive therapeutic modality, has received ever-increasing attention in recent years. Its specialized chemical agents, named sonosensitizers, are activated by low-intensity US to produce lethal reactive oxygen species (ROS) for oncotherapy. Compared with phototherapeutic strategies, SDT provides many noteworthy opportunities and benefits, such as deeper penetration depth, absence of phototoxicity, and fewer side effects. Nevertheless, previous studies have also demonstrated its intrinsic limitations. Thanks to the facile engineering nature of nanotechnology, numerous novel nanoplatforms are being applied in this emerging field to tackle these intrinsic barriers and achieve continuous innovations. In particular, the combination of SDT with other treatment strategies has demonstrated a superior efficacy in improving anticancer activity relative to that of monotherapies alone. Therefore, it is necessary to summarize the nanomaterial-assisted combinational sonodynamic cancer therapy applications. Herein, the design principles in achieving synergistic therapeutic effects based on nanomaterial engineering methods are highlighted. The ultimate goals are to stimulate the design of better-quality combined sonodynamic treatment schemes and provide innovative ideas for the perspectives of SDT in promoting its future transformation to clinical application.

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Section: Sonodynamic Therapy Combined With Other Treatmentsmentioning

confidence: 99%

Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

et al. 2020

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“…Reprinted with permission from Ref. [ 158 ] B: T1-weigthed MR images of mice treated with MNS or MNS-GOx at 0, 1, 8, 24 h post-injection [ 157 ]. Reprinted with permission from Ref.…”

Section: Classification Of Stimuli Responsive Two-dimensional Materiamentioning

confidence: 99%

“…5 B). He et al [ 157 ] used melanin as a biotemplate to prepare MnO 2 nanosheets with a size of ~70 nm and a thickness of ~2 nm under neutral conditions. Due to abundant catechol groups, melanin can be adsorbed on the surface of MnO 2 nanosheets effectively and achieve enhanced stability, water solubility and photothermal effect.…”

Section: Classification Of Stimuli Responsive Two-dimensional Materiamentioning

confidence: 99%

Recent advances of two-dimensional materials in smart drug delivery nano-systems

Zhang

Fan

Chen

et al. 2020

Bioactive Materials

145

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Smart drug delivery nano-systems show significant changes in their physical or chemical properties in response to slight change in environmental physical and/or chemical signals, and further releasing drugs adjusted to the progression of the disease at the right target and rate intelligently. Two-dimensional materials possess dramatic status extend all over various scientific and technological disciplines by reason of their exceptional unique properties in application of smart drug delivery nano-systems. In this review, we summarized current progress to highlight various kinds of two-dimensional materials drug carriers which are widely explored in smart drug delivery systems as well as classification of stimuli responsive two-dimensional materials and the advantages and disadvantages of their applications. Consequently, we anticipate that this review might inspire the development of new two-dimensional materials with smart drug delivery systems, and deepen researchers’ understanding of smart nano-carries based on two-dimensional materials.

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“…Cancer starvation therapy could noninvasively exhaust tumor cells by depriving crucial nutrients of tumor cells, such as glucose and oxygen [9][10][11]. Among various cancer starving agents, glucose oxidase (GOx) could catalyze the decomposition of glucose, the main energy supply of tumor cells, and simultaneously produces H 2 O 2 and H + for triggering subsequent treatment modalities, so GOx has attracted enormous interest in tailoring synergistic cancer therapeutic patterns [12][13][14][15][16][17][18][19][20]. For example, our group firstly integrated GOx-mediated starvation therapy with NO gas therapy mediated by L-arginine in the hollow mesoporous organo-silica nanoparticles (L-Arg-HMON-GOx) [21].…”

Section: Introductionmentioning

confidence: 99%

Janus γ-Fe2O3/SiO2-based nanotheranostics for dual-modal imaging and enhanced synergistic cancer starvation/chemodynamic therapy

et al. 2020

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Tracing drug release process with dual-modal hyperbranched polymer-gold nanoparticle complexes SCIENCE CHINA Chemistry 59, 1600 (2016); Sonodynamic therapy (SDT): a novel strategy for cancer nanotheranostics SCIENCE CHINA Life Sciences 61, 415 (2018); Bistratal Au@Bi2S3 nanobones for excellent NIR-triggered/multimodal imaging-guided synergistic therapy for liver cancer Bioactive Materials 6, 386 (2021); Environmentally responsive dual-targeting nanotheranostics for overcoming cancer multidrug resistance

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Glucose Oxidase-Instructed Traceable Self-Oxygenation/Hyperthermia Dually Enhanced Cancer Starvation Therapy

Cited by 144 publications

References 46 publications

Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

Recent advances of two-dimensional materials in smart drug delivery nano-systems

Janus γ-Fe2O3/SiO2-based nanotheranostics for dual-modal imaging and enhanced synergistic cancer starvation/chemodynamic therapy

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