Glutamatergic Control of Food Intake in Pigeons

Zeni, Lucia; Seidler, Heinrich; Carvalho, Nestor Antonio Schmidt de; Freitas, Candido Geraldo; Marino–Neto, José; Paschoalini, Marta Aparecida

doi:10.1016/s0091-3057(99)00153-7

Cited by 36 publications

(6 citation statements)

References 28 publications

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“…The results of this study were also consistent with the research result that ICV injection of glutamate in pigeons was able to decrease feed intake, in a study to explore the possible involvement of glutamatergic mechanisms in the control of food intake [12]. On the other hand, inhibition of vesicular glutamate uptake could increase feed intake in broilers [39].…”

Section: Discussionsupporting

confidence: 89%

“…Glutamate was previously demonstrated to be an endogenous agent involved in the neural control of food intake and body weight in mammals [12,13]. Systemic, ICV or local administration of glutamate or glutamate agonists into the lateral hypothalamus could evoke a dose-related stimulation of food intake in mammals [12,14]. Nonetheless, currently there is still little information on the impact of glutamate on feeding behavior in chickens, and results have contrasted those obtained in mammals [15-17].…”

Section: Introductionmentioning

confidence: 99%

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Effects of "Bioactive" amino acids leucine, glutamate, arginine and tryptophan on feed intake and mRNA expression of relative neuropeptides in broiler chicks

Wang

Khondowe

et al. 2012

J Animal Sci Biotechnol

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Feed intake control is vital to ensuring optimal nutrition and achieving full potential for growth and development in poultry. The aim of the present study was to investigate the effects of L-leucine, L-glutamate, L-tryptophan and L-arginine on feed intake and the mRNA expression levels of hypothalamic Neuropeptide involved in feed intake regulation in broiler chicks. Leucine, glutamate, tryptophan or arginine was intra-cerebroventricularly (ICV) administrated to 4d-old broiler chicks respectively and the feed intake were recorded at various time points. Quantitative PCR was performed to determine the hypothalamic mRNA expression levels of Neuropeptide Y (NPY), agouti related protein (AgRP), pro-opiomelanocortin (POMC), melanocortin receptor 4 (MC4R) and corticotrophin releasing factor (CRF). Our results showed that ICV administration of L-leucine (0.15 or 1.5 μmol) significantly (P < 0.05) increased feed intake up to 2 h post-administration period and elevated both hypothalamic NPY and AgRP mRNA expression levels. In contrast, ICV administration of L-glutamate (1.6 μmol) significantly (P < 0.05) decreased feed intake 0.25, 0.5 and 2 h post-injection, and increased hypothalamic CRF and MC4R mRNA expression levels. Meanwhile, both L-tryptophan (10 or 100 μg) and L-arginine (20 or 200 μg) had no significant effect on feed intake. These findings suggested that L-leucine and L-glutamate could act within the hypothalamus to influence food intake, and that both orexigenic and anorexigenic Neuropeptide genes might contribute directly to these effects.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Effects of "Bioactive" amino acids leucine, glutamate, arginine and tryptophan on feed intake and mRNA expression of relative neuropeptides in broiler chicks

Wang

Khondowe

et al. 2012

J Animal Sci Biotechnol

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“…However, PCP works primarily as an NMDA receptor antagonist, which blocks the activity of the NMDA receptor [3,20]. Various studies demonstrated that NMDA glutamatergic system has a role on the modu lation of feeding behaviors [5,18,21]. Some previous studies showed that systemic injection of the non competitive NMDA antagonist, MK801, increased food intake in rats [22].…”

Section: Discussionmentioning

confidence: 99%

“…Each mouse was immediately returned to its cage after injection and a weighed hop per of food was placed in the cage. The amount of con sumed cumulative food (standard laboratory mice chow) was measured (1-12 h) after injection of the solutions [5,15,16].…”

Section: Food Intake Evaluationmentioning

confidence: 99%

“…However, various studies showed that different receptors in the central nervous system such as dopaminergic, seretonergic, and nicotinic cholin ergic systems are involved in the modulation of behav ioral effect of PCP and its analogues. All of the above mentioned neural systems are main parts of central systems that are involved in control of different behav iors including food and water intake [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

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Pyrrole analogues of Phencyclidine decrease food and water consumption in mice

et al. 2011

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Various studies have shown that Phencyclidine (1 [1 phenylcyciohexyl] piperidine, PCP, I) and many of its analogues demonstrate pharmacological effects. In this paper effects of some new pyrrole derivatives of, (1 [1 phenylcyclohexyl] pyrrole I, II, and 1 [1 [4 methylphenyl][cyclohexyl]] pyrrole III) on food and water intake in mice were investigated. Animals were deprived for 24 h before initial of each test for food and water intake evaluation. PCP and its derivatives were injected intraperitoneally (i.p.) and then in 1-12 hour and 30-180 min post injection, the treated groups were measured for food and water intake, respectfully. The results obtained from the present study show that the pyrrole derivatives of PCP (II and III), decrease food and water intake in the deprived mice dramatically in comparison with the vehicle treated control groups. Our results sug gest that the pyrrole derivatives of phencyclidine (II and III) affect those parts of central nervous systems that are involved in feeding behavior.

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A novel procedure for assessing the effects of drugs on satiation in baboons: effects of memantine and dexfenfluramine

2008

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Rationale-Procedures for studying the effects of medications on satiation will assist the development of obesity medications.Objectives-Develop a procedure for measuring satiation during consumption of bland and highly palatable food, and determine the effect of acute intramuscular administration of dexfenfluramine (DFEN), which increases serotonin levels, and memantine (MEM), which blocks N-methyl-Daspartate receptors.Methods-A modified progressive ratio (PR) procedure was used to track changes in reinforcing strength when a food was consumed. The response requirement increased after each reinforcement, and reinforcing strength was estimated using the breakpoint (BP), which was the last completed response cost. There was one preferred food (sweet candy) and one chow pellet PR session per week. During each session, 4 male and 4 female adult baboons experienced three 1-hr PR trials, separated by 30 min. Chow pellets were available at all other times. We examined the BP for 1 to 20 candies or chow pellets. Drug effects were examined when baboons had access to 1 and 10 candies/pellets.Results-Breakpoints for candy were greater than for pellets. Varying the pellet/candy pieces per delivery, produced an inverted U-shaped function on the first trial, i.e., maximal BP was observed for 3 items, and the BP for multiple items, but not a single item, decreased across trials, i.e., BP decreased with food intake and satiation. DFEN and MEM decreased responding with the greatest effects at 10 deliveries suggesting that DFEN and MEM enhanced satiation.Conclusion-Drugs that enhance satiation for several types of food may be particularly effective for decreasing food intake.

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Glutamatergic Control of Food Intake in Pigeons

Cited by 36 publications

References 28 publications

Effects of "Bioactive" amino acids leucine, glutamate, arginine and tryptophan on feed intake and mRNA expression of relative neuropeptides in broiler chicks

Effects of "Bioactive" amino acids leucine, glutamate, arginine and tryptophan on feed intake and mRNA expression of relative neuropeptides in broiler chicks

Pyrrole analogues of Phencyclidine decrease food and water consumption in mice

A novel procedure for assessing the effects of drugs on satiation in baboons: effects of memantine and dexfenfluramine

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