Glycerol monolaurate improves performance, intestinal development, and muscle amino acids in yellow-feathered broilers via manipulating gut microbiota

Liu, Tao; Tang, Jun; Feng, Fengqin

doi:10.1007/s00253-020-10919-y

Cited by 34 publications

(60 citation statements)

References 40 publications

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“…It has been reported that higher weight gain, feed intake, nutrient utilization as well as better quality of poultry products can be obtained by manipulating gut microbiota ( Khan et al., 2020 ). Liu et al. (2020b) pointed that better performance, intestinal development and muscle composition in broilers were due to its strong antimicrobial capacity.…”

Section: Resultsmentioning

confidence: 99%

Research Note: Effects of glycerol monolaurate supplementation on egg production, biochemical indices, and gut microbiota of broiler breeders at the late stage of production

et al. 2021

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The objective of the present study was to determine the effect of glycerol monolaurate ( GML ) supplementation on egg production, biochemical indices, and gut microbiota of broiler breeders at the late stage of production. Total of 180 healthy Qingyuan Partridge broiler breeders were randomly assigned to 2 groups: 1) corn-soybean meal based diet, and 2) basal diet supplemented with 300 mg glycerol monolaurate/kg. Each treatment group had 6 replicates with 15 birds within each replicate. The experiment started at wk 33 and lasted for 8 weeks. Feed conversion rate, egg weight, egg shape index, shell breaking strength, and shell thickness were not different between control and treatment groups. Supplementation of GML significantly decreased the egg breaking rate. All blood chemical indices and antioxidant parameters were not affected by GML except total antioxidant capacity which increased significantly with GML supplementation. Alpha diversity indices (Shannon, Simpson, Chao1, Ace, goods_coverage, and PD_whole tree) were not different between the 2 groups. Composition of cecal microbiota was not affected by GML supplementation except Euryarchaeota and Proteobacteria at phylum level. Overall, supplementation of glycerol monolaurate at 300 mg/kg level improved eggshell quality but its effect on cecal microbiota composition was limited on broiler breeders at the late stage of production.

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Section: Resultsmentioning

confidence: 99%

Research Note: Effects of glycerol monolaurate supplementation on egg production, biochemical indices, and gut microbiota of broiler breeders at the late stage of production

et al. 2021

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“…Zhao, et al [ 69 ] reported improved Intestinal morphology by GML supplementation indicated by increased VH and VH: CD ratio. Liu, et al [ 70 ] reported improved growth, muscle amino acids, and intestinal morphology in broilers by GML supplementation (300, 450, and 600 mg/kg) mostly by influencing the gut microbiota function and community. Pan and Yu [ 71 ] demonstrated that short chain fatty acids (SCFAs) can act as energy source for intestinal epithelial cells and enhance the growth and proliferation of intestinal cells.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, one possible clarification for improving gut morphology by GML may be derived from the high SCFAs levels in the gastrointestinal tract. Furthermore, increased SCFAs may improve the intestinal health and may assist the host in maintaining mucosal barrier integrity [ 70 , 72 ]. Mo, et al [ 73 ] showed that dietary GML improved the intestinal integrity and gut barrier function in mice.…”

Section: Discussionmentioning

confidence: 99%

Effect of Dietary Medium-Chain α-Monoglycerides on the Growth Performance, Intestinal Histomorphology, Amino Acid Digestibility, and Broiler Chickens’ Blood Biochemical Parameters

Amer

A-Nasser

Al-Khalaifah

et al. 2020

Animals

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This trial was conducted to assess the impact of medium-chain α-monoglycerides, glycerol monolaurate (GML) supplementation on the growth performance, apparent ileal digestibility coefficient (AID%) of amino acids, intestinal histomorphology, and blood biochemical parameters of broiler chickens. Three-day-old chicks (76.82 g ± 0.40, n = 200) were haphazardly allocated to four experimental groups with five replicates for each (10 chicks/replicate). The treatments consisted of basal diets supplemented with four glycerol monolaurate levels; 0, 1, 3, or 5 g kg−1 (GML0, GML1, GML3, and GML5, respectively). Growth performance was determined at three periods (starter, grower, and finisher). Dietary GML had no significant effect on the growth performance parameters (body weight, weight gain, and feed conversion ratio) through all the experimental periods. GML1 diet increased the AID% of leucine and decreased the AID% of arginine. GML1 diet increased the duodenal and jejunal villous height and the jejunal muscle thickness. GML3 and GML5 diets increased the goblet cell count in the duodenum. GML supplementation increased the serum level of high density lipoprotein (HDL)-cholesterol. GML5 diet increased the serum levels of IgM and interleukin 10 compared to the control group. We could conclude that dietary supplementation of glycerol monolaurate can supplement broiler chicken diets up to 5 g kg−1 to enhance the immune status and intestinal histomorphology of birds with no improving effect on growth performance.

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“…In addition, no effects were reported on the BW, BWG, and FCR after dietary supplementation with four GML levels (0, 1, 3, or 5 g/kg) during all experimental periods (3). Conversely, increased ADFI and BW and reduced FCR were observed in the 28–56-day-old yellow-feathered broilers with dietary GML (18). Broilers fed with GML had increased BWG, ADG, and feed consumption and decreased FCR (9).…”

Section: Discussionmentioning

confidence: 99%

“…Intestinal integrity is a key factor for preventing the invasion of pathogenic microorganisms in broilers (28). Dietary GML tends to increase the VH and VCR and decrease the CD of the jejunum, thus improving growth performance (18). In this study, dietary GML decreased CD and increased VCR in the jejuna of broilers with increasing dose.…”

Section: Discussionmentioning

confidence: 99%

Glycerol monolaurate ameliorated intestinal barrier and immunity in broilers by regulating intestinal inflammation, antioxidant balance, and intestinal microbiota

Kong¹,

Wang

Xiao

et al. 2021

Preprint

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Extensive interactions occur between a poultry host and its gut microbiome. Glycerol monolaurate (GML) possesses a large range of antimicrobial and immunoregulatory properties. This study was conducted to investigate the impact of different doses of GML (basal diets complemented with 0, 300, 600, 900, or 1200 mg/kg GML) on growth performance, intestinal barrier, and cecal microbiota in broiler chicks. Results revealed that feed intake increased after 900 and 1200 mg/kg GML were administered during the entire 14-day experiment period. Dietary GML decreased crypt depth and increased the villus height-to-crypt depth ratio of the jejunum. In the serum and jejunum, supplementation with more than 600 mg/kg GML reduced interleukin-1β, tumor necrosis factor-α, and malondialdehyde levels and increased the levels of immunoglobulin G, jejunal mucin 2, total antioxidant capacity, and total superoxide dismutase. GML down-regulated jejunal interleukin-1β and interferon-γ expression and increased the mRNA level of zonula occludens 1 and occludin. A reduced expression of toll-like receptor 4 and a tendency of down-regulated nuclear factor kappa-B was shown in GML-treated groups. In addition, GML modulated the composition of the cecal microbiota of the broilers, improved microbial diversity, and increased the abundance of butyrate-producing bacteria. Spearman's correlation analysis revealed that the genera Barnesiella, Coprobacter, Lachnospiraceae, Faecalibacterium, Bacteroides, Odoriacter, and Parabacteroides were related to inflammation and intestinal integrity. In conclusion, GML ameliorated intestinal morphology and barrier function in broiler chicks probably by regulating intestinal immune and antioxidant balance, as well as intestinal microbiota.

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Glycerol monolaurate improves performance, intestinal development, and muscle amino acids in yellow-feathered broilers via manipulating gut microbiota

Cited by 34 publications

References 40 publications

Research Note: Effects of glycerol monolaurate supplementation on egg production, biochemical indices, and gut microbiota of broiler breeders at the late stage of production

Research Note: Effects of glycerol monolaurate supplementation on egg production, biochemical indices, and gut microbiota of broiler breeders at the late stage of production

Effect of Dietary Medium-Chain α-Monoglycerides on the Growth Performance, Intestinal Histomorphology, Amino Acid Digestibility, and Broiler Chickens’ Blood Biochemical Parameters

Glycerol monolaurate ameliorated intestinal barrier and immunity in broilers by regulating intestinal inflammation, antioxidant balance, and intestinal microbiota

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