Gnotobiology

Foster, Henry L.

doi:10.1016/b978-0-12-742150-6.50013-x

Cited by 4 publications

(6 citation statements)

References 27 publications

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“…The birth weights shown in Table 1 for newborn preterm rabbits of different gestational ages are similar to those reported by others for preterm rabbits of comparable ages (12,14). Average body weights were related directly to gestational age (Table 1) but inversely to litter size (Table 2).…”

Section: Resultssupporting

confidence: 71%

“…This was equivalent to the daily amount of milk ingested during the first 2 postnatal days by term pups weighed prior to and after being fed by the dam. Initially, the preterm pups were fed a pasteurized milk formula (Charles-River Breeding Lab., Willmington, MA) reported to be nutritionally adequate for newborn rabbits delivered gnotobiotically just before term (12). Subsequently, since the pups failed to thrive on the formula rabbit milk was substituted (3).…”

Section: Methodsmentioning

confidence: 99%

“…The fastest photochemical reaction is a Z to E isomerization reaction (5,8) which in human infants yields primarily the 4Z,15E-bilirubin isomer (6). This reaction is readily reversible and up to 20% of the total bilirubin can be converted to this isomer during phototherapy (9)(10)(11)(12).…”

mentioning

confidence: 99%

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The Preterm Rabbit: A Model for the Study of Acute and Chronic Effects of Premature Birth

Lorenzo

1985

Pediatr Res

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Section: Resultssupporting

confidence: 71%

Section: Methodsmentioning

confidence: 99%

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The Preterm Rabbit: A Model for the Study of Acute and Chronic Effects of Premature Birth

Lorenzo

1985

Pediatr Res

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“…After being mated to expand their number and associated with a cocktail of nonpathogenic bacteria to prime their immune system, rederived rodents were transferred to so-called barrier rooms for large-scale production. The room-level barrier to infection entailed HEPA filtration of incoming air, disinfection of room equipment and supplies, and limited access to trained and properly gowned personnel (Dubos and Schaedler 1960;Foster 1980;Schaedler and Orcutt 1983;Trexler and Orcutt 1999).…”

Section: Rederivation and Barrier Room Productionmentioning

confidence: 99%

Role of Housing Modalities on Management and Surveillance Strategies for Adventitious Agents of Rodents

Shek¹

2008

ILAR Journal

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Specific pathogen-free (SPF) rodents for modern biomedical research need to be free of pathogens and other infectious agents that may not produce disease but nevertheless cause research interference. To meet this need, rodents have been rederived to eliminate adventitious agents and then housed in room- to cage-level barrier systems to exclude microbial contaminants. Because barriers can and do fail, routine health monitoring (HM) is necessary to verify the SPF status of colonies. Testing without strict adherence to biosecurity practices, however, can lead to the inadvertent transfer of unrecognized, inapparent agents among institutions and colonies. Microisolation caging systems have become popular for housing SPF rodents because they are versatile and provide a highly effective cage-level barrier to the entry and spread of adventitious agents. But when a microisolation-caged colony is contaminated, the cage-level barrier impedes the spread of infection and so the prevalence of infection is often low, which increases the chance of missing a contamination and complicates the corroboration of unexpected positive findings. The expanding production of genetically engineered mutant (GEM) rodent strains at research institutions, where biosecurity practices vary and the risk of microbial contamination can be high, underscores the importance of accurate HM results in mitigating the risk of the introduction and spread of microbial contaminants with the exchange of mutant rodent strains among investigators and institutions.

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“…For many years, colonies of germfree animals have been important tools in the study of diseases of suspected microbial background (Foster, 1980;Coates, 1982;Sasaki, 1985). In recent years, the athymic nude rat has found application in several studies dealing with the thymic dependence of various diseases (Hinrichs & Humphres, 1983;Ito & Kamiyama, 1984;Taubman et al, 1984).…”

Section: Abstract: Rats Mutant Strain; Laboratory Animals Germfree;mentioning

confidence: 99%

Quantitative studies of lymphoid organs, blood and lymph in inbred athymic and euthymic LEW rats under germfree and specified-pathogen-free conditions

Klausen

Hougen²

1987

Lab Anim

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SummaryFour groups of inbred male LEW rats were examined: A, germfree athymicj B, specified pathogen free (SPF) athymicj C, germfree euthymicj D, SPF euthymic. All animals were killed at 18 weeks and compared with respect to body weight, histological appearance and cell density of the lymphoid organs, haematological values and differential counts of bone marrow, peripheral blood and lymph.Athymic rats had a lower body weight, less densely populated lymphoid organs, and fewer lymphocytes in the blood and lymph compared with euthymic animals. No difference was seen between athymic rats under germfree and SPF conditions, and in general the differences between athymic and euthymic animals were less pronounced under germfree conditions.

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Gnotobiology

Cited by 4 publications

References 27 publications

The Preterm Rabbit: A Model for the Study of Acute and Chronic Effects of Premature Birth

The Preterm Rabbit: A Model for the Study of Acute and Chronic Effects of Premature Birth

Role of Housing Modalities on Management and Surveillance Strategies for Adventitious Agents of Rodents

Quantitative studies of lymphoid organs, blood and lymph in inbred athymic and euthymic LEW rats under germfree and specified-pathogen-free conditions

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