Goblet cell carcinoid of appendix: A rare case with literature review

Mitra, Bhaskar; Pal, Mallika; Paul, Biswanath; Saha, Tarak Nath; Maiti, Ananda

doi:10.1016/j.ijscr.2013.01.007

Cited by 6 publications

(5 citation statements)

References 16 publications

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“…Older age seems to be associated with GCC, where mean age of GCC patients is around 52 years [24] , and others have reported appendicular GCC in two females (60 and 54 year olds) and a male (>60 years) [25] , [26] , [27] , [28] . Although a case of 31-year-old man has also been described in the literature [29] . In our cohort, the treatment for appendicular GCC is in agreement with others, where the main treatment of appendicular GCC is appendectomy and right hemicolectomy [25] , [30] .…”

Section: Discussionmentioning

confidence: 99%

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Frequency, characteristics and outcomes of appendicular neuroendocrine tumors: A cross-sectional study from an academic tertiary care hospital

Abdelaal

Ansari

Al‐Bozom

et al. 2017

Annals of Medicine &Amp; Surgery

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BackgroundAppendicular neuroendocrine tumors (NET, Carcinoid tumors) of the appendix are rare and mostly diagnosed incidentally on the post-operative histopathological examination. NET are usually associated with good 5-year survival rates. We aimed to assess our experience for the diagnosis and management of NET over 11 years.MethodIt is a retrospective chart review of all clinically suspected patients with acute appendicitis who underwent emergent appendectomy with intention to treat between January 2004–December 2014, and were clinically followed up until 2016.ResultsDuring the study period, a total of 13641 patients underwent emergency appendectomy, of which 32 were histologically confirmed NET. The mean age of the NET cases was 25.3 ± 7.9 years; 78% were males and all were clinically presented with acute appendicitis. The mean leucocyte was 15 ± 14 × 109 per Liter, and mean tumor size was 4.86 ± 3.18 (ranged 1.5–13) mm. The median length of hospital stay was 4 (2–15) days. One patient had right hemicolectomy; diagnosed with right colonic cancer with NET being an incidental finding as part of histopathological assessment. Another patient required a second stage procedure; he was diagnosed as goblet cell carcinoid with positive margin. None of the patients died 30-day postoperatively and all of them survived on clinical follow-up that ranged between 2 and 13 years.ConclusionCarcinoid tumors of the appendix are rare and typically diagnosed incidentally. Detailed examination of routine appendectomy specimens is the key for diagnosis. Simple appendectomy suffices for tumors <2 cm for adequate clearance. Appendicular carcinoid tumors are associated with good long-term outcomes.

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Section: Discussionmentioning

confidence: 99%

“…The current literature suggests inconsistency for the exact biological behavior of GCC [29] , it could be metastasized in 15–30% of cases, particularly among higher age group [31] . Therefore, clinical follow-up of such patients is highly recommended.…”

Section: Discussionmentioning

confidence: 99%

Frequency, characteristics and outcomes of appendicular neuroendocrine tumors: A cross-sectional study from an academic tertiary care hospital

Abdelaal

Ansari

Al‐Bozom

et al. 2017

Annals of Medicine &Amp; Surgery

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“…However, there are several authors who do not find this treatment approach adequate and recommend more aggressive surgical resection 23 . In the literature, there are studies suggesting that right hemicolectomy should be performed in patients with high-grade malignant NET, particularly in tumours located in the root of the appendix 24 . In one patient in the present study, the tumour was located in the appendix radix and the surgical margin was positive; therefore, right hemicolectomy was performed for this patient as the second operation.…”

Section: Discussionmentioning

confidence: 99%

Neuroendocrine tumours in patients operated for acute appendicitis: a retrospective clinical study

Arslan¹,

Kurt²

2021

Arch Balk Med Union

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Tumeurs neuroendocrines chez les patients opérés pour une appendicite aiguë: une étude clinique rétrospectiveIntroduction. L'objectif de l'étude était de déterminer l'incidence des tumeurs neuroendocrines chez les patients subissant une appendicectomie due à une appendicite aiguë et d'étudier le traitement et le suivi de ces tumeurs. Matériels et méthodes. Les données de 6592 patients opérés d'une appendicite aiguë dans deux centres de santé différents entre janvier 2012 et mai 2020 ont été obtenues grâce à un scan réalisé sur une base de données électronique. Quatorze patients atteints de pathologies neuroendocriniennes ont été inclus dans l'étude. Résultats. Parmi les 6592 patients subissant une appendicectomie inclus dans l'étude, 14 avaient des tumeurs neuroendocrines. Sur ces 14 patients, six étaient de sexe masculin et huit de sexe féminin. L'âge moyen des patients était de 36,71 ans. Six tumeurs étaient distales, sept médiales et une radicale. La taille moyenne des tumeurs était de 1,17 cm. Une hémicolectomie droite a été réalisée chez deux patients avec tumeurs

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“…The morphological alterations in the tracheal and lung tissues were observed by a routinely used staining protocol with haematoxylin and eosin (H&E). The goblet cells in the chicken tracheal epithelium were stained by periodic acid-Schiff (PAS) staining following a previously described protocol (Mitra et al, 2013). The number of goblet cells in the chicken tracheal epithelium was assessed by a computerized image analysis program, Image-Pro Plus version 6.0 (Media Cybernetics, Rockville, MD, USA).…”

Section: Haematoxylin and Eosin And Periodic Acid-schiff Stainingmentioning

confidence: 99%

Effects of lipopolysaccharide on the histomorphology and expression of toll-like receptor 4 in the chicken trachea and lung

Ansari

Huang

et al. 2016

Avian Pathology

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Endotoxin or lipopolysaccharide (LPS) exposure can cause injury to the respiratory airways and in response, the respiratory epithelia express toll-like receptors (TLRs) in many species. However, its role in the innate immunity in the avian respiratory system is poorly understood. The aim of the present study was to evaluate the effects of LPS on the chicken trachea and lung. After intraperitoneal LPS or saline injection, the trachea and lungs were harvested at 0, 12, 36 and 72 h (n = 6 at each time point) and histopathologically analysed using haematoxylin and eosin and periodic acid-Schiff staining, while TLR4 expression was determined by immunohistochemistry and secretory Immunoglobulin A (SIgA) levels by enzyme-linked immunosorbent assay. After LPS stimulation, we observed a remarkable decrease in the number of goblet cells along with obvious disruption and desquamation of the ciliated epithelium in the trachea, blurring of the boundary between pulmonary lobules, narrowed or indistinguishable lumen of the pulmonary atria and leukostasis in the lungs. Following LPS stimulation, TLR4 protein expression was up-regulated in both the trachea and the lungs and was found on the ciliated columnar cells as well as in the submucosa of the trachea, and in the lungs on parenchymal and immune cells. However, SIgA levels were only up-regulated in the trachea at 12 h following LPS stimulation. Hence, this report provides novel information about the effects of LPS on the microstructure of the lower respiratory tract and it is concluded that its intra-peritoneal administration leads to TLR4-mediated destruction of the tracheal epithelium and pulmonary inflammation along with increased SIgA expression in the tracheal mucosa.

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Goblet cell carcinoid of appendix: A rare case with literature review

Abstract: Considering the difficulty of clinical suspicion of this tumor, presenting as appendicitis and incidentally found during appendectomies, we review the goblet cell carcinoid of the appendix using an illustrative case report.

Cited by 6 publications

References 16 publications

Frequency, characteristics and outcomes of appendicular neuroendocrine tumors: A cross-sectional study from an academic tertiary care hospital

Frequency, characteristics and outcomes of appendicular neuroendocrine tumors: A cross-sectional study from an academic tertiary care hospital

Neuroendocrine tumours in patients operated for acute appendicitis: a retrospective clinical study

Effects of lipopolysaccharide on the histomorphology and expression of toll-like receptor 4 in the chicken trachea and lung

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