BACKGROUND
Gradient non-linearity (GNL) leads to biased apparent diffusion coefficients (ADCs) in diffusion weighted imaging. A gradient non-linearity correction (GNLC) method has been developed for whole body systems, but yet to be tested for the new compact 3T (C3T) scanner which exhibits more complex GNL due to its asymmetrical design.
PURPOSE
To assess the improvement of ADC quantification with GNLC for the C3T scanner.
STUDY TYPE
Phantom measurements and retrospective analysis of patient data.
PHANTOM/SUBJECTS
A diffusion quality control phantom with vials containing 0-30% polyvinylpyrrolidone in water was used. For in-vivo data, 12 patient exams were analyzed (median age =33).
FIELD STRENGTH/SEQUENCE
Imaging was performed on the C3T and two commercial 3T scanners. A clinical DWI (TR = 10000 ms, TE = min, b = 1000 s/mm2) sequence was used for phantom imaging and 10 patient cases and a clinical DTI (TR = 6000-10000 ms, TE = min, b = 1000s/mm2) sequence was used for two patient cases.
ASSESSMENT
The 0% vial was measured along three orthogonal axes, and at two different temperatures. The ADC for each concentration was compared between the C3T and two whole body scanners. Cerebrospinal fluid and white matter ADCs were quantified for patient and compared to values in literature.
STATISTICAL TEST
Paired t-test and two-way ANOVA
RESULTS
For all PVP concentrations, the corrected ADC was within 2.5% of the reference ADC. On average, the ADC of cerebrospinal fluid and white matter post-GNLC were within 1% and 6% of values reported in literature respectively and were significantly different from the uncorrected data (p<0.05).
DATA CONCLUSION
This study demonstrated that GNL effects were more severe for the C3T due to the asymmetric gradient design, but our implementation of a GNLC compensated for these effects, resulting in ADC values that are in good agreement with values from literature.