Grafting of functionalized polymer on porous silicon surface using Grignard reagent

Functionalization of Oxide‐Free Silicon Surfaces for Biosensing Applications

“…An interesting alternative is the electrochemical functionalization by ethynyl groups via electrochemical oxidation of ethynyl‐MgBr, forming a thin alkyne terminated polymer that may be further functionalized via a click a coupling reaction. [ 70,71 ]…”

“…An interesting alternative is the electrochemical functionalization by ethynyl groups via electrochemical oxidation of ethynyl-MgBr, forming a thin alkyne terminated polymer that may be further functionalized via a click a coupling reaction. [70,71] While the above-mentioned four grafting strategies are the most frequently applied to form SiC bonded monolayer, several new approaches have been reported the last decade.…”

“…In similar manners, proteins and peptides have been coupled to non-oxidized Si. [71,86,87] The reversed coupling between an amine terminated surface and the carboxylic acid functionality of biomolecules have also been reported by applying a variety of approaches such as light activated grafting of ethylenediamine [88] and hydrosilylation of protected amines [89] The amine functionality may also be useful in order to attach bifunctional polyethylene glycol (PEG) linkers that prevents biofouling or as a way of attaching other functionalities such as thiol, biotin, [82] or maleimide. [90]…”

Porous Silicon-Based Photonic Biosensors: Current Status and Emerging Applications

“…PSi matrices are attractive and versatile scaffolds for the incorporation of polymers and hydrogels. ,− ,− The principle concepts of designing and fabricating PSi/polymer hybrids were recently reviewed by Segal and co-workers . The integrated polymer can provide mechanical and chemical stability to the PSi host and offer new functionalities for molecular recognition and sensing. ,, Moreover, the integration of polymers within nanostructured PSi enables rational device design that can display a combination of controlled chemical and physical characteristics that are not exhibited by either individual component. , These hybrids have been extensively studied for drug delivery applications, − but few studies have reported their use for sensing and biosensing applications. , For example, a design of responsive devices through various mechanisms, ,, the development of dual-mode platforms, and the ability to improve the biosensor sensitivity were reported. Krepker et al developed a dual-functionalized PSi/hydrogel hybrid for the detection of organophosphorus compounds (OPCs) .…”

“…132 The integrated polymer can provide mechanical and chemical stability to the PSi host and offer new functionalities for molecular recognition and sensing. 89,127,133 Moreover, the integration of polymers within nanostructured PSi enables rational device design that can display a combination of controlled chemical and physical characteristics that are not exhibited by either individual component. 86,134 These hybrids have been extensively studied for drug delivery applications, 135−139 but few studies have reported their use for sensing and biosensing applications.…”