Graphene Oxide–Based Nanomaterials: An Insight into Retinal Prosthesis

Yang, Jia; Yu, Zih Yu; Cheng, Shui-Ming; Chung, Johnson; Liu, Xiao; Wu, Chien-Tung; Lin, Shien Fong; Chen, Guan Yu

doi:10.3390/ijms21082957

Cited by 19 publications

(15 citation statements)

References 130 publications

(147 reference statements)

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“…Given this, a study showed that micropatterned graphene oxide (GO), when integrated with a retinal prosthesis, enabled the adhesion of retinal cells. In addition, GO-based nanomaterials provide enhanced safety, improved tissue regeneration, and repair [ 147 ]. Ranibizumab is an active humanized monoclonal antibody that neutralizes vascular endothelial growth factor A. Yan et al synthesized a formulation based on ranibizumab-conjugated iron oxide (Fe 3 O 4 )/PEGylated polylactide-co-glycolide (PEG-PLGA) for the treatment of neovascular age-related macular degeneration.…”

Section: Challenges and Future Perspectivesmentioning

confidence: 99%

Section: Challenges and Future Perspectivesmentioning

confidence: 99%

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Nano-Biomaterials for Retinal Regeneration

Sharma

Hazlett

et al. 2021

Nanomaterials

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Nanoscience and nanotechnology have revolutionized key areas of environmental sciences, including biological and physical sciences. Nanoscience is useful in interconnecting these sciences to find new hybrid avenues targeted at improving daily life. Pharmaceuticals, regenerative medicine, and stem cell research are among the prominent segments of biological sciences that will be improved by nanostructure innovations. The present review was written to present a comprehensive insight into various emerging nanomaterials, such as nanoparticles, nanowires, hybrid nanostructures, and nanoscaffolds, that have been useful in mice for ocular tissue engineering and regeneration. Furthermore, the current status, future perspectives, and challenges of nanotechnology in tracking cells or nanostructures in the eye and their use in modified regenerative ophthalmology mechanisms have also been proposed and discussed in detail. In the present review, various research findings on the use of nano-biomaterials in retinal regeneration and retinal remediation are presented, and these findings might be useful for future clinical applications.

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Section: Challenges and Future Perspectivesmentioning

confidence: 99%

Section: Challenges and Future Perspectivesmentioning

confidence: 99%

Nano-Biomaterials for Retinal Regeneration

Sharma

Hazlett

et al. 2021

Nanomaterials

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“…Despite all the promising results summarized in this article, there remain many hurdles to be resolved to enable successful restoration of vision. For example, not discussed in this article focusing on the visual acuity enhancement, proximate interfacing with the retinal tissue is another important issue of current retinal prostheses, thus newer materials such as conducting polymers, carbon nanotubes, and graphene oxide have been recently explored [205][206][207][208][209]. Future endeavors are expected to overcome the existing technological and physiological limitations.…”

Section: Other New Approachesmentioning

confidence: 99%

Retinal Prosthetic Approaches to Enhance Visual Perception for Blind Patients

et al. 2020

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Retinal prostheses are implantable devices that aim to restore the vision of blind patients suffering from retinal degeneration, mainly by artificially stimulating the remaining retinal neurons. Some retinal prostheses have successfully reached the stage of clinical trials; however, these devices can only restore vision partially and remain insufficient to enable patients to conduct everyday life independently. The visual acuity of the artificial vision is limited by various factors from both engineering and physiological perspectives. To overcome those issues and further enhance the visual resolution of retinal prostheses, a variety of retinal prosthetic approaches have been proposed, based on optimization of the geometries of electrode arrays and stimulation pulse parameters. Other retinal stimulation modalities such as optics, ultrasound, and magnetics have also been utilized to address the limitations in conventional electrical stimulation. Although none of these approaches have been clinically proven to fully restore the function of a degenerated retina, the extensive efforts made in this field have demonstrated a series of encouraging findings for the next generation of retinal prostheses, and these could potentially enhance the visual acuity of retinal prostheses. In this article, a comprehensive and up-to-date overview of retinal prosthetic strategies is provided, with a specific focus on a quantitative assessment of visual acuity results from various retinal stimulation technologies. The aim is to highlight future directions toward high-resolution retinal prostheses.

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“…Such retinal stimulation methods that have been used to restore visual functions include electrical retinal prosthesis [ 4 , 9 , 10 ], optogenetics [ 11 ], photochemistry [ 12 ], ultrasonic stimulation [ 13 ], etc. Among them electrical stimulation based retinal prosthesis have been well studied for decades and recognized as the mainstream for practical applications [ 14 ]. In recent years, such retinal prostheses have achieved great progress in the device safety, integration and miniaturization, including microelectrode arrays, stimulator, wireless circuits, chip packaging, and implantation surgery [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

A facile and comprehensive algorithm for electrical response identification in mouse retinal ganglion cells

Qin²,

Lu³

et al. 2021

PLoS ONE

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Retinal prostheses can restore the basic visual function of patients with retinal degeneration, which relies on effective electrical stimulation to evoke the physiological activities of retinal ganglion cells (RGCs). Current electrical stimulation strategies have defects such as unstable effects and insufficient stimulation positions, therefore, it is crucial to determine the optimal pulse parameters for precise and safe electrical stimulation. Biphasic voltages (cathode-first) with a pulse width of 25 ms and different amplitudes were used to ex vivo stimulate RGCs of three wild-type (WT) mice using a commercial microelectrode array (MEA) recording system. An algorithm is developed to automatically realize both spike-sorting and electrical response identification for the spike signals recorded. Measured from three WT mouse retinas, the total numbers of RGC units and responsive RGC units were 1193 and 151, respectively. In addition, the optimal pulse amplitude range for electrical stimulation was determined to be 0.43 V-1.3 V. The processing results of the automatic algorithm we proposed shows high consistency with those using traditional manual processing. We anticipate the new algorithm can not only speed up the elaborate electrophysiological data processing, but also optimize pulse parameters for the electrical stimulation strategy of neural prostheses.

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Graphene Oxide–Based Nanomaterials: An Insight into Retinal Prosthesis

Cited by 19 publications

References 130 publications

Nano-Biomaterials for Retinal Regeneration

Nano-Biomaterials for Retinal Regeneration

Retinal Prosthetic Approaches to Enhance Visual Perception for Blind Patients

A facile and comprehensive algorithm for electrical response identification in mouse retinal ganglion cells

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