“Green-reduced” graphene oxide induces in vitro an enhanced biomimetic mineralization of polycaprolactone electrospun meshes

Marrella, Alessandra; Tedeschi, Giacomo; Giannoni, Paolo; Lagazzo, Alberto; Sbrana, Francesca; Barberis, Fabrizio; Quarto, Rodolfo; Puglisi, Francesca; Scaglione, Silvia

doi:10.1016/j.msec.2018.08.052

Cited by 44 publications

(32 citation statements)

References 67 publications

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“…We and others have shown that graphene-based materials are capable of supporting and enhancing stem cell growth and differentiation towards osteogenic lineage [16][17][18][19]. Most recently, we have reported the development of graphene-cellulose (G-C) 'paper' for 3D human ADSC support and osteoinduction [20].…”

Section: Introductionmentioning

confidence: 99%

Electrical stimulation-induced osteogenesis of human adipose derived stem cells using a conductive graphene-cellulose scaffold

Liu

Crook

et al. 2020

Materials Science and Engineering: C

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Section: Introductionmentioning

confidence: 99%

Electrical stimulation-induced osteogenesis of human adipose derived stem cells using a conductive graphene-cellulose scaffold

Liu

Crook

et al. 2020

Materials Science and Engineering: C

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“…Composite structures of rGO with various polymers typically demonstrate improvements in their physicochemical and biological features [31][32][33][34][35][36][37][38] . Added as a filler to PCL-based scaffolds, rGO increases the strength, stiffness, and toughness of the scaffolds and produces structures that are more mechanically competent and suitable for load-bearing applications 32,33 . The physicochemical properties of rGO increase the hydrophilicity of various scaffolds and their capacity to adsorb proteins and growth factors 33,34 .…”

mentioning

confidence: 99%

Fabrication and characterization of mechanically competent 3D printed polycaprolactone-reduced graphene oxide scaffolds

Seyedsalehi

Daneshmandi

Barajaa

et al. 2020

Sci Rep

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The ability to produce constructs with a high control over the bulk geometry and internal architecture has situated 3D printing as an attractive fabrication technique for scaffolds. Various designs and inks are actively investigated to prepare scaffolds for different tissues. In this work, we prepared 3D printed composite scaffolds comprising polycaprolactone (PCL) and various amounts of reduced graphene oxide (rGO) at 0.5, 1, and 3 wt.%. We employed a two-step fabrication process to ensure an even mixture and distribution of the rGO sheets within the PCL matrix. The inks were prepared by creating composite PCL-rGO films through solvent evaporation casting that were subsequently fed into the 3D printer for extrusion. The resultant scaffolds were seamlessly integrated, and 3D printed with high fidelity and consistency across all groups. This, together with the homogeneous dispersion of the rGO sheets within the polymer matrix, significantly improved the compressive strength and stiffness by 185% and 150%, respectively, at 0.5 wt.% rGO inclusion. The in vitro response of the scaffolds was assessed using human adipose-derived stem cells. All scaffolds were cytocompatible and supported cell growth and viability. These mechanically reinforced and biologically compatible 3D printed PCL-rGO scaffolds are a promising platform for regenerative engineering applications.

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“…Titanium (Ti) is a metal that is lightweight and used for replacement of bone because of its outstanding biocompatibility, corrosion-resistant, mechanical, and physical properties. Moreover, it is used as an implant material for effective osseointegration and bone ingrowth at the implant interface [ 297 , 298 , 299 , 300 ]. Due to the strong non-covalent binding abilities of graphene and graphene oxide (GO), it endorses osteogenesis and stem cell differentiation [ 301 ] To enhance the osteogenic potential of scaffolds graphene and its derivatives can be combined with other biomaterials [ 302 , 303 ].…”

Section: Biomimetic Tissue-engineering Aspectsmentioning

confidence: 99%

Biomimetic Aspects of Restorative Dentistry Biomaterials

et al. 2020

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Biomimetic has emerged as a multi-disciplinary science in several biomedical subjects in recent decades, including biomaterials and dentistry. In restorative dentistry, biomimetic approaches have been applied for a range of applications, such as restoring tooth defects using bioinspired peptides to achieve remineralization, bioactive and biomimetic biomaterials, and tissue engineering for regeneration. Advancements in the modern adhesive restorative materials, understanding of biomaterial–tissue interaction at the nano and microscale further enhanced the restorative materials’ properties (such as color, morphology, and strength) to mimic natural teeth. In addition, the tissue-engineering approaches resulted in regeneration of lost or damaged dental tissues mimicking their natural counterpart. The aim of the present article is to review various biomimetic approaches used to replace lost or damaged dental tissues using restorative biomaterials and tissue-engineering techniques. In addition, tooth structure, and various biomimetic properties of dental restorative materials and tissue-engineering scaffold materials, are discussed.

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“Green-reduced” graphene oxide induces in vitro an enhanced biomimetic mineralization of polycaprolactone electrospun meshes

Cited by 44 publications

References 67 publications

Electrical stimulation-induced osteogenesis of human adipose derived stem cells using a conductive graphene-cellulose scaffold

Electrical stimulation-induced osteogenesis of human adipose derived stem cells using a conductive graphene-cellulose scaffold

Fabrication and characterization of mechanically competent 3D printed polycaprolactone-reduced graphene oxide scaffolds

Biomimetic Aspects of Restorative Dentistry Biomaterials

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