Green synthesis of silver nanoparticles using Azadirachta indica aqueous leaf extract

Ahmed, Shakeel; Saifullah, -; Ahmad, Mudasir; Swami, Babu Lal; Ikram, Saiqa

doi:10.1016/j.jrras.2015.06.006

Cited by 904 publications

(494 citation statements)

References 27 publications

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“…The band 1506 cm -1 corresponds to N-H stretching vibrations in amide-II; 1382 cm -1 represents monosubstituted alkynes (Vani et al, 2011;Rajiv et al, 2013). The observed peak at 1116.72 cm -1 denote -C-OC-linkages, or -C-O-bonds (Ahmed et al, 2015). The observed peaks are mainly attributed to flavonoids and terpenoids present in plants extract.…”

Section: Ftir Spectroscopymentioning

confidence: 99%

Green synthesis of zinc oxide nanoparticles using Azadirachta indica A. Juss. leaves extract and its antibacterial activity against Xanthomonas orzyae pv. oryzae

Mankad¹,

Patil²,

Patel³

et al. 2016

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Section: Ftir Spectroscopymentioning

confidence: 99%

Green synthesis of zinc oxide nanoparticles using Azadirachta indica A. Juss. leaves extract and its antibacterial activity against Xanthomonas orzyae pv. oryzae

Mankad¹,

Patil²,

Patel³

et al. 2016

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“…The leaves were then grinded by denotes of motor pistal followed by filtration so as to abstract the solid waste. Solvent extraction [48][49][50] of leaves was then done using 30% ethanol and water. The extract was then stored at 4°C for further use [51][52][53].…”

Section: Collection Of Leaves and Extract Preparationmentioning

confidence: 99%

Effect of Silver Nanoparticle-Mediated Wound Therapy on Biochemical, Hematological, and Histological Parameters

Chauhan

Shrivastava

Prasad

et al. 2018

Asian J Pharm Clin Res

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Methods: Extraction of Syzygium cumini was done and was used for silver nanoparticle synthesis. The synthesized nanoparticles were characterized by ultraviolet-visible spectroscopy, Fourier transform infrared spectroscopy, scanning electron microscopy, and transmission electron microscopy, which confirms the availability of nanosilver particles with marginally spherical morphology. The particles were then carried forward for treating impaired diabetic wounds in Wistar rat models. Regular photography was done and wound healing parameters were monitored throughout the study along with analyzing other parameters such as biochemical, hematological, and histological parameters. Results:The study showed that the sizes of the synthesized nanoparticles are below 100 nm. The results obtained from in vivo studies showed efficient wound healing potential of silver nanoparticles as compared to pre-existing drug povidone-iodine, i.e., the percentage reduction in wound area after therapy is 96.09% in case of biosynthesized silver nanoparticle-treated group, 97.7% reduction in chemically synthesized silver nanoparticle-treated group, 64.28% reduction in case of pre-existing drug povidone-iodine-treated group, 37.5% reduction in case of diabetic control group (diabetic), and 97.5% reduction in normal control group (non-diabetic). Results showed that biosynthesized silver nanoparticles showed less toxicity with respect to liver and kidney functions. Skin histology results showed increased sign of wound healing in biosynthesized silver nanoparticles. Hematology results showed no such variation. Conclusion:The study will help to synthesize new economically viable potential biosynthesized nanoparticles along with providing the approach to develop the medication at nanoscale level.

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“…EPA announces registration of nanosilver pesticide product in food container. Because nanosilver pesticides causes severe nephrotoxic dilemma in which consumer led to acute renal shut down and fatal prognostic result appear due to this [20][21][22][23]. Gaillet et al in recent era discovered small size silver nanoparticles their potential negative effects after oral exposure executes severe nephrotoxic effect [24].…”

Section: Nephrotoxicity From Histological Point Of Viewmentioning

confidence: 99%

Small Size Silver Nanoparticle’s Corrosive and Hazardous Manifestations on Mature and Developing Kidney Following Accumulation in Pregnant Mice and Offspring’s after Serial Oral Bolus Experimental Application: A New Chapter in Teratogenicity and Toxicity Search

Prakash¹,

Singh²,

Pani³

2017

J Cytol Histol

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The most important and worldwide utilized nanomaterial is silver metal nanoparticle which after synthesis changed to colloidal or powdered form. After successful characterization different sizes of these particles measured if intermixed and confirmed to different size ranges. Different sizes segregates into various size groups. Specific small or large size silver in powder form also readily available in market for various applications and experiments after biological or herbal synthesis and characterization. 1 to 20 nm size ranges are grouped under inconsiderable or smaller size range whereas 20 to 100 nm size ranges or above sizes are grouped under considerable or bigger size range. Following serial oral ingestion for experiment, aqueous and magnetic stirred synthesized AgNps of less than 20 nm of null account size accumulate in mature and developing kidneys of pregnant Swiss Albino mice and their freshly born fetuses after passing through blood vessels of pregnant mice and after absorption from gastro intestinal tract and accumulate in mature kidney due to trap inside. These particles also crosses blood placental barrier reaches fetus body in womb and accumulate in developing kidney due to same mechanism. These particles also surprisingly execute sex specific corrosive manifestation. We have examined the corrosive and hazardous effect of 10 gestational days (5 to 15 gestational days) serial oral bolus ingestion of 2.75 to 18.5 nm size range AgNps colloidal solution in a lower dose of 0.35 (1), 0.55 (2) mg/kg. b.w, in an in between dose of 4 (3), 8 (4) mg/ kg. b.w. and in a higher dose of 12 (5) and 16 (6) mg/kg. b.w. treatment on mature and developing right and left kidneys of pregnant mice and fetuses. Groups were designated as 1(Control); 2, 3, 4, 5 and 6 (Treated). At lower dose we report negligible histological findings and at higher bolus dose we report marked histological findings. This particular size range group silver nano particles (AgNps) treatment turns into insignificant reduction in kidney weight and height at higher dose, with some hemorrhagic focuses along with histological alterations. Predominantly agenesis and severe atrophy of renal corpuscles, increase of urinary space, generalized anasarca of podocytes, degeneration and dysmorphology with congestion of proximal convoluted tubules and distal convoluted tubules, loss of brush border membranes and damage of squamous epithelium of loop of Henley with severe congestion in medullary rays and collecting ducts are observed in routine histology. The in between dose demonstrated in between results. These manifestations are found quite same to chronic and acute renal failure with hematuria. All these alterations, in prolong sustain, could land up to beginning of apoptosis and progress of cell necrosis in these vital organs.

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Green synthesis of silver nanoparticles using Azadirachta indica aqueous leaf extract

Cited by 904 publications

References 27 publications

Green synthesis of zinc oxide nanoparticles using Azadirachta indica A. Juss. leaves extract and its antibacterial activity against Xanthomonas orzyae pv. oryzae

Green synthesis of zinc oxide nanoparticles using Azadirachta indica A. Juss. leaves extract and its antibacterial activity against Xanthomonas orzyae pv. oryzae

Effect of Silver Nanoparticle-Mediated Wound Therapy on Biochemical, Hematological, and Histological Parameters

Small Size Silver Nanoparticle’s Corrosive and Hazardous Manifestations on Mature and Developing Kidney Following Accumulation in Pregnant Mice and Offspring’s after Serial Oral Bolus Experimental Application: A New Chapter in Teratogenicity and Toxicity Search

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