Group II metabotropic glutamate receptor activation in the basolateral amygdala mediates individual differences in stress-induced changes in rapid eye movement sleep

Sweeten, Brook L.W.; Adkins, Austin M.; Wellman, Laurie L.; Sanford, Larry D.

doi:10.1016/j.pnpbp.2020.110014

Cited by 9 publications

(14 citation statements)

References 44 publications

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“…We have found individual differences in the REM response in outbred Wistar strain rats ( Wellman et al, 2016 , 2017 ; Sweeten et al, 2020a , Sweeten et al, 2020b ) that parallel those observed with uncontrollable and controllable stress. REM vulnerable (Vul) rats show decreases in REM after training with IS whereas REM resilient (Res) rats showed no decreases, or even increases, in REM after IS ( Wellman et al, 2016 , 2017 ; Sweeten et al, 2020a , Sweeten et al, 2020b ). The rapidly normalized and enhanced REM in Res rats suggests a rapid recovery of sleep homeostasis ( Wellman et al, 2018 ) which is consistent with stress resilience.…”

Section: Modulators Of Stress Responsesmentioning

confidence: 57%

“…As with our work with controllable and uncontrollable stress, these differences in REM occur even though freezing and SIH are identical in both groups. The Vul and Res phenotypes are also differentially responsive to other stressors (e.g., novel chamber ( Sweeten et al, 2020a , Sweeten et al, 2020b ) and simulated space radiation ( Britten et al, 2021 )) indicating the differences are not limited to footshock stress. Contextual fear memories also produce virtually identical sleep, freezing and SIH responses to those they exhibited to IS in Vul and Res rats ( Wellman et al, 2016 , 2017 ; Sweeten et al, 2020a , Sweeten et al, 2020b ).…”

Section: Modulators Of Stress Responsesmentioning

confidence: 99%

See 1 more Smart Citation

Modeling integrated stress, sleep, fear and neuroimmune responses: Relevance for understanding trauma and stress-related disorders

Sanford

Wellman

Adkins

et al. 2023

Neurobiology of Stress

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Section: Modulators Of Stress Responsesmentioning

confidence: 57%

Section: Modulators Of Stress Responsesmentioning

confidence: 99%

Modeling integrated stress, sleep, fear and neuroimmune responses: Relevance for understanding trauma and stress-related disorders

Sanford

Wellman

Adkins

et al. 2023

Neurobiology of Stress

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“…121 Further, a single treatment with LY341495 improved isolated mice performance in the Y maze test but not in the novel object recognition test, while repeating the treatments were efficient for both tasks. [121][122][123] Conversely, mGluR2/3 agonist, LY379268, has also improved recognition memory impairment in SI rats. 121,124 Earlier investigations have suggested and decreased BDNF induced by chronic isolation were modified in EE.…”

Section: Drug Tre Atmentsmentioning

confidence: 99%

“…Additionally, Results have revealed that in socially isolated mice, the excitatory presynaptic release of pyramidal neurons in the mPFC has attenuated, and metabotropic glutamate receptor 2/3 (mGluR2/3) antagonist, LY341495 , played a crucial role in recovering working memory by building reasonably vast synaptic strength in the mPFC in SI‐reared mice 121 . Further, a single treatment with LY341495 improved isolated mice performance in the Y maze test but not in the novel object recognition test, while repeating the treatments were efficient for both tasks 121‐123 . Conversely, mGluR2/3 agonist, LY379268 , has also improved recognition memory impairment in SI rats 121,124 .…”

Section: Drug Treatmentsmentioning

confidence: 99%

Depresssion, anxiety and other cognitive consequences of social isolation: Drug and non‐drug treatments

Zadeh

Rahmani

Alidadi

et al. 2021

Int J Clinical Practice

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Social interaction has a crucial role in human well-being, both mentally and physically. 1 Human social isolation (SI) happens when the social relationship between individuals become deficient. 2 Moreover, it mostly occurs when the number of individuals, who are members of social links, decrease, or the qualification of social relations, diminishes. During SI, people experience unpleasant situations mentally, emotionally, and spiritually. 3,4 Some conditions force individuals to leave human groups and reduce their socia9l interactions, presence in the population, and group activities. Being single, getting a divorce and separation may also result in isolation. 2,5 Further, weak connections and lack of social support have shown to be significant risk factors of isolation, which result in loneliness, stress, and committing suicide. 6,7 Meanwhile, some infectious diseases such as COVID-19, AIDS and some physical disorders have shown to develop SI in humans. 8,9 Also, some studies have confirmed impairment in sensory processing is significantly correlated with depression.Extreme sensory processing patterns make humans feel hopeless and depressed. 10,11 As previous scientific research has described the association between vision disabilities and hearing problems with isolation and reduced human relation. 12 Loneliness is considered as a risk factor for many psychiatric disorders such as adjustment disorder, chronic stress, insomnia and also late-life dementia 9 which may be long lasting. 13 Adverse effects on cognition and behaviour, decision-making, and pain perception are followed by social isolation. 14,15 SI has shown to change the immune system, glutamate system, and hormones. [15][16][17] Besides, cardiovascular disease, high blood pressure, stroke, and developmental neurodegenerative diseases have occurred during SI. 15 It has been

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“…Stress has both subjective and objective effects on sleep quantity, quality, and structure, which appear to be mediated by changes in metabotropic glutamate receptor functioning in limbic brain regions ( Highland et al, 2019 ; Sweeten et al, 2021 ). In addition, sleep deprivation leads to reduced hippocampal neurogenesis and plasticity, potentially impairing resilience to stress ( Saletin et al, 2016 ).…”

Section: Key Research Areas In the Neurobiology Of Resilience And Thementioning

confidence: 99%

Harnessing the Neurobiology of Resilience to Protect the Mental Well-Being of Healthcare Workers During the COVID-19 Pandemic

Rajkumar

2021

Front. Psychol.

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Healthcare workers are at a high risk of psychological morbidity in the face of the COVID-19 pandemic. However, there is significant variability in the impact of this crisis on individual healthcare workers, which can be best explained through an appreciation of the construct of resilience. Broadly speaking, resilience refers to the ability to successfully adapt to stressful or traumatic events, and thus plays a key role in determining mental health outcomes following exposure to such events. A proper understanding of resilience is vital in enabling a shift from a reactive to a proactive approach for protecting and promoting the mental well-being of healthcare workers. Research in the past decade has identified six areas that provide promising leads in understanding the biological basis of individual variations in resilience. These are: (1) the key role played by the monoamines noradrenaline and serotonin, (2) the centrality of the hypothalamic-pituitary-adrenal axis in influencing stress vulnerability and resilience, (3) the intimate links between the immune system and stress sensitivity, (4) the role of epigenetic modulation of gene expression in influencing the stress response, (5) the role played by certain neuropeptides as a natural “brake” mechanism in the face of stress, and (6) the neurobiological mechanisms by which environmental factors, such as exercise, diet, and social support, influence resilience to subsequent life events. Though much of this research is still in its early stages, it has already provided valuable information on which strategies – including dietary changes, lifestyle modification, environmental modification, psychosocial interventions, and even pharmacological treatments – may prove to be useful in fostering resilience in individuals and groups. This paper examines the above evidence more closely, with a specific focus on the challenges faced by healthcare workers during the COVID-19 pandemic, and provides suggestions regarding how it may be translated into real-world interventions, as well as how the more tentative hypotheses advanced in this field may be tested during this critical period.

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Group II metabotropic glutamate receptor activation in the basolateral amygdala mediates individual differences in stress-induced changes in rapid eye movement sleep

Cited by 9 publications

References 44 publications

Modeling integrated stress, sleep, fear and neuroimmune responses: Relevance for understanding trauma and stress-related disorders

Modeling integrated stress, sleep, fear and neuroimmune responses: Relevance for understanding trauma and stress-related disorders

Depresssion, anxiety and other cognitive consequences of social isolation: Drug and non‐drug treatments

Harnessing the Neurobiology of Resilience to Protect the Mental Well-Being of Healthcare Workers During the COVID-19 Pandemic

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