Growth curve modelling to determine distinct BMI trajectory groups in HIV-positive adults on antiretroviral therapy in South Africa

Brennan, Alana T.; Berry, Kaitlyn M.; Rosen, Sydney; Stokes, Andrew; Crowther, Nigel J; George, Jaya; Raal, Frederick J.; Cassim, Naseem; Sanne, Ian; Long, Lawrence; Fox, Matthew P.

doi:10.1097/qad.0000000000002302

Cited by 14 publications

(11 citation statements)

References 50 publications

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“…The gain in CD4+ T cells increased with baseline BMI, and with a longer follow-up, the gain in CD4+ T cells in obese patients changed significantly [24,25]. CD4+ T cells continued to increase with the length of follow-up, especially in the first year, when the rate of CD4+ T-cell growth was most significant, a finding that is consistent with other studies [26,27]. The gain level of CD4+ T cells in overweight patients was not significantly different from that in normal BMI patients in the first year, while the gain level of CD4 + T cells in obese patients was higher than that in normal BMI patients in our study.…”

Section: Plos Onesupporting

confidence: 89%

High baseline body mass index predicts recovery of CD4+ T lymphocytes for HIV/AIDS patients receiving long-term antiviral therapy

et al. 2022

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The relationship between baseline BMI and CD4+ T cells during follow-up in HIV patients in China requires further evaluation. We conducted a retrospective cohort study based on adult AIDS patients who underwent or received antiretroviral therapy from 2003 to 2019 in Guangxi, China. BMI was divided into categories and compared, and after adjusting for BMI being related to the change in CD4 lymphocyte count, with normal weight as the reference group, the BMI before treatment was positively correlated with the changes in CD4+ T cells at different time periods. Among them, obese patients had significant CD4+ cell gain. In patients with pretreatment CD4+ T lymphocyte counts <200 cells/μL, a higher BMI was associated with an increased likelihood of achieving immunologic reconstitution [≥350 cells/μL: AHR: 1.02(1.01, 1.04), P = 0.004; ≥500 cells/μL: AHR: 1.03 (1.01, 1.05), P = 0.004]. Underweight in HIV patients was a risk factor for poor viral suppression [AHR: 1.24 (1.04, 1.48), P = 0.016]. Our study demonstrated that HIV/AIDS patients receiving ART with higher baseline BMI had better immune reconstitution and that baseline BMI could be an important predictor of immune reconstitution in patients receiving ART. Baseline BMI was not associated with virological failure, but a lower baseline BMI indicated poor viral suppression during follow-up.

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Section: Plos Onesupporting

confidence: 89%

High baseline body mass index predicts recovery of CD4+ T lymphocytes for HIV/AIDS patients receiving long-term antiviral therapy

et al. 2022

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“…As for BMI, we found statistically significant differences in proportions of overweight and obesity (62.5% in controls vs 30.6%). Cumulative evidence suggests a tendency of increased BMI in PLWHIV, which seems abrupt in the first year of ART [ 30 ] and more apparent in patients using protease inhibitors. [ 31 ] Nonetheless, the proportion of obesity in PLWHIV was comparable to what has been reported previously (ie, about one-third of PLWHIV).…”

Section: Discussionmentioning

confidence: 99%

“…[ 31 ] Nonetheless, the proportion of obesity in PLWHIV was comparable to what has been reported previously (ie, about one-third of PLWHIV). [ 30 , 31 ]…”

Section: Discussionmentioning

confidence: 99%

Sociodemographic, behavioral, and geriatric characteristics in older adults with and without HIV

Titon

Júnior

et al. 2021

Medicine

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Older adults with human immunodeficiency virus (HIV) have higher risks for early manifestations of age-related disabilities. The objective of this study was to compare HIV-positive and HIV-negative adults aged ≥50 years in relation to sociodemographic, behavioral, and geriatric characteristics. A case-control study was conducted with a >90% estimated statistical power. A total of 52 individuals living with HIV were matched by age, sex, and neighborhood of residence with 104 community controls. Age-related disabilities were assessed throughout a comprehensive geriatric assessment. Review of medical records and interviews were used to obtain behavioral and clinical covariates. No statistical differences on clinically significant age-related disabilities were found. However, multivariate regression analyses, controlling for education and income, revealed that behavioral (use of condom [odds ratio {OR}: 7.03; 95% confidence intervals {CI}: 2.80-7.65] and number of medical visits [OR: 1.25; 95%CI: 1.09-1.43]), along with faster gait speed (OR: 17.68; 95%CI: 2.55-122.85) and lower body and muscle mass indexes were independently associated with HIV (OR: .88; 95%CI: .79-.98 and OR: .72; 95%CI: .54-.97, respectively). In summary, results on age-related disabilities between groups could mean that public policies on HIV might be contributing to patients' positive outcomes regardless of the effects of aging, albeit gait speed, body and muscle mass indexes were independently associated with HIV. Screenings for age-related disabilities in specialized HIV services are recommended.Abbreviations: ADL = Barthel Index for Activities of Daily Living, ART = antiretroviral treatment, BMI = body mass index, CGA = comprehensive geriatric assessment, CNID = chronic non-infectious diseases, GS = geriatric syndromes, HIV = human immunodeficiency virus, IADL = Lawton Scale for Instrumental Activities of Daily Living, MNA = Mini Nutritional Assessment, PLWHIV = people living with HIV, PNLWHIV = people not living with HIV, TCC = testing and counseling center.

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“…It is marked the decreasing number of TLC and CD4 among people living with HIV (PLHIV) then followed by symptoms like persistent diarrhoea, drastic weight loss without knowing the reason, fever and muscle ache (Pitri, 2013). As a result, PLHIV will experience nutritional status disorders, which is marked by a low BMI score (Pusdiklat, 2014;Brennan, 2019). Excessive catabolism occurs followed by lower levels of albumin in the blood.…”

Section: Introductionmentioning

confidence: 99%

Clinical Manifestation of Bmi, Tlc, Albumin and Cd4 After Provision of Snakehead Nugget and Colored Fruit Juice to People With Hiv

Ria

Siahaan

Nasution

et al. 2022

MGI

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Snakehead fish has high content of zinc and albumin, it can be given to people with immune disorder. Snakehead fish can be made into various kind of food product that are high in nutrients, have aestetic value, and taste like nugget. The effectiveness of zinc and albumin function can work optimally when the consumption is combined with food ingredient that are high in bioactive substances such as lycopene, anthocyanin, flavonoid, karetonoid, bromelain, papain and quercetin. The purpose of this study was to analyze the effectof snakehead nugget administration and colored fruit juices simultaneously on clinical manifestation, BMI, TLC, albumin and CD4 value in PLHIV at HIV/AIDS Rehabilitation Center in Medan. The design of research was quasy experimental with pre and post test design. The subjects was 40 people who lived at HIV/AIDS Rehabilitation Center in Medan and given snackhead fish nugget and colored fruit juice for 24 days. The data analysis used dependent T-test, after data normality test had previously been carried out. There was effect before and after administration of snakehead fish nuggets and colored fruit juice on clinical manifestation, BMI, TLC and CD4 levels with p value <0.05. It is necessary to provide treatment in longer term as preventive measure for the emergence of various clinical manifestations as well as to increase BMI, TLC, albumin and CD4 in PLHIV at HIV/AIDS Rehabilitation Center in Medan.

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Growth curve modelling to determine distinct BMI trajectory groups in HIV-positive adults on antiretroviral therapy in South Africa

Cited by 14 publications

References 50 publications

High baseline body mass index predicts recovery of CD4+ T lymphocytes for HIV/AIDS patients receiving long-term antiviral therapy

High baseline body mass index predicts recovery of CD4+ T lymphocytes for HIV/AIDS patients receiving long-term antiviral therapy

Sociodemographic, behavioral, and geriatric characteristics in older adults with and without HIV

Clinical Manifestation of Bmi, Tlc, Albumin and Cd4 After Provision of Snakehead Nugget and Colored Fruit Juice to People With Hiv

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