GST M1/T1 and MTHFR polymorphisms as risk factors for hypertension

Genetic polymorphisms influence runners’ responses to the dietary ingestion of antioxidant supplementation based on pequi oil (Caryocar brasiliense Camb.): a before-after study

“…Because GST M1 and T1 null genotypes result in a complete absence of activity in their respective enzymes [52,68], these common deletion polymorphisms have been widely investigated for their effect on the risk of myocardial infarction [142], hypertension [80,103], and smoking-related and nonrelated coronary artery disease (CAD); [1,50,54,84,130,140]. However, these studies have yielded contradictory results, with some studies showing a significant association, and others showing no such association [140].…”

“…For the GSTT1 polymorphism, a meta-analysis of 19 studies including 8,020 cases and 11,501 controls [140] has indicated no correlation between GSTT1 null genotype and CAD risk [140]. GSTT1 null genotype has been also reported as a protective factor against CAD [50] and hypertension [80], as well as a risk factor for CAD independent of genotype-smoking interaction [1]. Our study corroborates the last of these results, given that this genotype presented a greater number of leukocytes and platelets as well as higher and significant values of TG and VLDL, mainly before pequi-oil supplementation.…”

Xenobiotic Detoxification Genes and Their Role in the Development of Pneumonia

“…В многочисленных исследованиях в разных лабо раториях показана корреляция мажорного варианта GSTT1 + с различными заболеваниями сердечно сосу дистой системы и другими патологиями, ассоциирован ными с курением и неблагоприятной экологией [30,32,33]. Подавляющее число больных исследованных групп (80,4%) являются носителями функционального алле ля GSTT1 (вариант + /+ или +/null).…”

Polymorphism in cardiovascular diseases (CVD) susceptibility loci in the azores islands (Portugal)

“…Conformity with Hardy-Weinberg equilibrium expectations (HW) was assessed using an exact test. Allelic frequencies observed in our population were compared with those reported for mainland Portugal [10][11][12][13][14][15][16] and several European and non-European populations [17][18][19][20][21][22][23][24][25][26][27][28][29], using an exact test of population differenttiation. For the polymorphic positions in F5 and MTHFR loci, gametic phase was estimated using a Bayesian test, by applying an ELB algorithm.…”