GSTM1 gene polymorphism as a possible marker for susceptibility to head and neck cancers among Japanese smokers

Kihara, Masako; Kihara, Masahiro; Kubota, Akira; Furukawa, Madoka; Kimura, Hirokazu

doi:10.1016/s0304-3835(96)04584-3

Cited by 50 publications

(30 citation statements)

References 24 publications

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“…We speculate that smoking may be responsible for the increased risk in males because glutathione S-transferase genes have been reported to detoxify nicotine and smoke (13). Previous studies on the interaction of GSTM1 and GSTT1 with smoking in tobacco-associated cancer have shown that the deletion of the GSTM1 and GSTT1 genes may increase cancer risk in smokers (9,25), whereas another study reported an interaction with tobacco chewing but not with smoking for head and neck squamous cell carcinoma (22). Further studies on the effects of smoking and GSTM1 and GSTT1 genotypes will clarify the role of smoking-gene interactions in nasopharyngeal carcinoma.…”

Section: Discussionmentioning

confidence: 90%

GSTM1 and GSTT1 Gene Deletions and the Risk for Nasopharyngeal Carcinoma in Han Chinese

Guo

O’Brien

Zeng

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Southern China is a major nasopharyngeal carcinomaendemic region. Environmental factors and genetic susceptibility contribute to nasopharyngeal carcinoma development in this area. Polymorphic deletions of GSTM1 and GSTT1 genes involved in the detoxification of potentially carcinogenic agents may be a risk factor for nasopharyngeal carcinoma. To investigate the roles of genetic variations of GSTM1 and GSTT1 in nasopharyngeal carcinoma susceptibility in the Chinese population, we conducted a case-control study of 350 nasopharyngeal carcinoma cases and 622 controls. GSTM1 and GSTT1 deletion variants were genotyped by multiplex PCR assays. Logistic regression analysis was used to estimate odds ratios and 95% confidence intervals (95% CI). No significant association was observed for either GSTM1-or GSTT1-null genotype independently in the contribution to nasopharyngeal carcinoma risk. To explore possible joint effects of the GSTM1-and GSTT1-null polymorphisms with each other and with other risk factors for nasopharyngeal carcinoma, we examined the association between each combined genotype and the risk for nasopharyngeal carcinoma stratified by gender and EBV replication status. We found that individuals who carried GSTM1/ GSTT1 -double null genotype had a higher risk for nasopharyngeal carcinoma in the male population (odds ratio, 1.76; 95% confidence interval, 1.04-2.97; P = 0.03); however, this was not significant after correction for multiple comparisons. No statistical difference was found between cases and controls in females and the subpopulation positive for immunoglobulin A antibodies to EBV capsid antigen for combined genotypes. Our results suggest that the GSTM1/GSTT1 -double null genotype may be a risk factor for nasopharyngeal carcinoma among males in southern China, but this result warrants confirmation in other studies. (Cancer Epidemiol Biomarkers Prev 2008;17(7):1760 -3)

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Section: Discussionmentioning

confidence: 90%

GSTM1 and GSTT1 Gene Deletions and the Risk for Nasopharyngeal Carcinoma in Han Chinese

Guo

O’Brien

Zeng

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…In Asia, large differences could be observed between countries. The frequencies in India varied from 24% to 37%, 78,80,84,90,96 in Japan from 39.8% to 48.7% 73,77,[91][92][93][94] , although the only study from Taiwan observed a frequency of 57.7%. 95 In South America these values ranged from 38.2% to 48.7% 71,79,97,98 and in Europe and United States from 51% to 54.8%.…”

Section: Population Frequenciesmentioning

confidence: 93%

“…44,83,92,94 The oral cavity, pharynx, and larynx are unique structures with different functions and possibly different sensitivities to carcinogens, especially alcohol and tobacco. Studies suggest that HPV may be the etiologic agent involved in most pharyngeal tumors (particularly those in the oropharynx).…”

Section: Controlsmentioning

confidence: 99%

“…Some of the publications do not provide sufficient details on the characteristics of the cases and controls, the way controls have been recruited or even the period where this occurred. 66,77,79,85,88,92,94 In some hospital-based studies information on the causes for hospital admission were not provided. Nevertheless, we were able to evaluate the influence of control group source in this analysis.…”

Section: Controlsmentioning

confidence: 99%

“…The categorization of individuals as never/ex/current/ever smokers could be inaccurate and not sufficiently standardized across studies. 77,79,81,88,92,94 Misclassification of exposure could lead to biased results so this must be taken into account when interpreting the findings. It would be preferable to further characterize tobacco consumption as lifetime exposure (pack-years), but in the present meta-analysis and pooled analysis this was not possible because of the heterogeneous categorization of the smoking habits.…”

Section: Controlsmentioning

confidence: 99%

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Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers: a HuGE-GSEC review

Varela-Lema

Taioli

Ruano-Raviña

et al. 2008

Genetics in Medicine

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The association of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers was assessed through a metaanalysis of published case-control studies and a pooled analysis of both published and unpublished case-control studies from the Genetic Susceptibility to Environmental Carcinogens database (http://www.upci.upmc.edu/research/ccps/ccontrol/ index.html). Thirty publications used in the meta-analysis included a total of 7783 subjects (3177 cases and 4606 controls); 21 datasets, 9397 subjects (3130 cases and 6267 controls) were included in the pooled analysis. The GSTM1 deletion was 2-fold more likely to occur in African American and African cases than controls (odds ratio: 1.7, 95% confidence interval: 0.9-3.3), although this was not observed among whites (odds ratio: 1.0, 95% confidence interval: 0.9-1.1). The metaanalysis and pooled analysis showed a significant association between oral and pharyngeal cancer and the CYP1A1 MspI homozygous variant (meta-OR m2/m2 : 1.9, 95% confidence interval: 1.4-2.7; Pooled OR m2m2 : 2.0, 95% confidence interval:1.3-3.1; OR m1m2 or [infi]m2m2 : 1.3, 95% confidence interval: 1.1-1.6). The association was present for the CYP1A1 (exon 7) polymorphism (OR Val/Val : 2.2, 95% confidence interval: 1.1-4.5) in ever smokers. A joint effect was observed for GSTM1 homozygous deletion and the CYP1A1 m1m2 variant on cancer risk. Our findings suggest that tobacco use and genetic factors play a significant role in oral and pharyngeal cancer. Genet Med 2008:10(6):369-384. Key Words: GSTM1, CYP1A1, oral and pharyngeal cancers, epidemiology, meta-analysis and pooled analysis Glutathione S-transferasesThe Glutathione S-transferases (GSTs) comprise a family of phase II detoxifying enzymes that catalyze a large number of reactions taking place between the cytosolic glutathione and compounds containing an electrophilic center. 1 These enzymes are involved in the elimination of xenobiotics and endogenous products of oxidative stress formed as a result of aerobic metabolism, exposure to ionizing radiation or any other process that causes cellular damage. Substrates for GSTs include acetaldehyde and several polyaromatic hydrocarbons (PAHs) found in tobacco smoke. The main steps for GST catalysis includes the formation of a complex with the cytosolic glutathione and the ionization of the sulfydryl group of this enzyme bound to glutathione to yield a highly reactive thiolate anion through hydrogen bonding with the adjacent hydroxyl

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Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and oral cavity cancer

et al. 1999

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GSTM1 gene polymorphism as a possible marker for susceptibility to head and neck cancers among Japanese smokers

Cited by 50 publications

References 24 publications

GSTM1 and GSTT1 Gene Deletions and the Risk for Nasopharyngeal Carcinoma in Han Chinese

GSTM1 and GSTT1 Gene Deletions and the Risk for Nasopharyngeal Carcinoma in Han Chinese

Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers: a HuGE-GSEC review

Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and oral cavity cancer

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