Gut-Brain-Microbiota Axis: Antibiotics and Functional Gastrointestinal Disorders

Karakan, Tarkan; Özkul, Ceren; Akkol, Esra Küpeli; Bilici, Saniye; Sobarzo‐Sánchez, Eduardo; Capasso, Raffaele

doi:10.3390/nu13020389

Cited by 105 publications

(53 citation statements)

References 102 publications

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“…The gut microbiota has the ability to modulate the ENS and CNS, with the ability to produce many neurotransmitters, as in the human brain [ 49 ]. Among the neurotransmitters produced locally by the gut microbiota, there are local neurotransmitters such as γ-aminobutyric acid (GABA), noradrenaline, dopamine, serotonin (5-hydroxytryptamine-5-HT), melatonin, histamine and acetylcholine, and a biologically active catecholamine form in the lumen, thereby can affect the nervous system activity [ 50 , 51 , 52 ].…”

Section: Importance Of Labs In Dairy Foods In Terms Of Healthmentioning

confidence: 99%

“…), and many environmental factors (stress, fear, social interaction, etc. ), and the composition of the intestinal microbiota plays a key role in this modulation [ 49 ]. In fact, as the evidence on the effectiveness of diet in the intestinal microbiota increases in recent years, the “gut–brain axis” network, known as bi-directional communication, will be started to be called three-directional as the “food–gut–brain axis” [ 48 , 55 ].…”

Section: Importance Of Labs In Dairy Foods In Terms Of Healthmentioning

confidence: 99%

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Dairy Lactic Acid Bacteria and Their Potential Function in Dietetics: The Food–Gut-Health Axis

Ağagündüz

Yılmaz

Şahin

et al. 2021

Foods

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Fermented dairy products are the good source of different species of live lactic acid bacteria (LAB), which are beneficial microbes well characterized for their health-promoting potential. Traditionally, dietary intake of fermented dairy foods has been related to different health-promoting benefits including antimicrobial activity and modulation of the immune system, among others. In recent years, emerging evidence suggests a contribution of dairy LAB in the prophylaxis and therapy of non-communicable diseases. Live bacterial cells or their metabolites can directly impact physiological responses and/or act as signalling molecules mediating more complex communications. This review provides up-to-date knowledge on the interactions between LAB isolated from dairy products (dairy LAB) and human health by discussing the concept of the food–gut-health axis. In particular, some bioactivities and probiotic potentials of dairy LAB have been provided on their involvement in the gut–brain axis and non-communicable diseases mainly focusing on their potential in the treatment of obesity, cardiovascular diseases, diabetes mellitus, inflammatory bowel diseases, and cancer.

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Section: Importance Of Labs In Dairy Foods In Terms Of Healthmentioning

confidence: 99%

Section: Importance Of Labs In Dairy Foods In Terms Of Healthmentioning

confidence: 99%

Dairy Lactic Acid Bacteria and Their Potential Function in Dietetics: The Food–Gut-Health Axis

Ağagündüz

Yılmaz

Şahin

et al. 2021

Foods

View full text Add to dashboard Cite

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“…Today through the advances of evolutionary molecular genetics for the analysis of the intestinal microbiome, we can better understand how 99% of our genes, which are microbial through co-evolution, can affect our immune system and state of health. New promises for the treatment of the chronic diseases opens through recent studies that claim that through diet and a healthy way of living we can modify not only the expression of the human genome, but also the intestinal microbiota [ 260 ].…”

Section: Photobiomodulation Applied On the Gut–lung–brain Axismentioning

confidence: 99%

Probiotics, Photobiomodulation, and Disease Management: Controversies and Challenges

Ailioaie

Litscher

2021

IJMS

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In recent decades, researchers around the world have been studying intensively how micro-organisms that are present inside living organisms could affect the main processes of life, namely health and pathological conditions of mind or body. They discovered a relationship between the whole microbial colonization and the initiation and development of different medical disorders. Besides already known probiotics, novel products such as postbiotics and paraprobiotics have been developed in recent years to create new non-viable micro-organisms or bacterial-free extracts, which can provide benefits to the host with additional bioactivity to probiotics, but without the risk of side effects. The best alternatives in the use of probiotics and postbiotics to maintain the health of the intestinal microbiota and to prevent the attachment of pathogens to children and adults are highlighted and discussed as controversies and challenges. Updated knowledge of the molecular and cellular mechanisms involved in the balance between microbiota and immune system for the introspection on the gut–lung–brain axis could reveal the latest benefits and perspectives of applied photobiomics for health. Multiple interconditioning between photobiomodulation (PBM), probiotics, and the human microbiota, their effects on the human body, and their implications for the management of viral infectious diseases is essential. Coupled complex PBM and probiotic interventions can control the microbiome, improve the activity of the immune system, and save the lives of people with immune imbalances. There is an urgent need to seek and develop innovative treatments to successfully interact with the microbiota and the human immune system in the coronavirus crisis. In the near future, photobiomics and metabolomics should be applied innovatively in the SARS-CoV-2 crisis (to study and design new therapies for COVID-19 immediately), to discover how bacteria can help us through adequate energy biostimulation to combat this pandemic, so that we can find the key to the hidden code of communication between RNA viruses, bacteria, and our body.

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“…Similarly, emotional factors, such as stress or depression, can influence the development of chronic gastrointestinal diseases, such as inflammatory bowel disease (the most common being Crohn's disease and ulcerative colitis) and irritable bowel syndrome [23].…”

Section: Bi-directional Regulation Mechanism Of Brain-gut Axismentioning

confidence: 99%

Maintaining the Balance of Intestinal Flora through the Diet: Effective Prevention of Illness

Zhang

et al. 2021

Foods

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The human body is home to a complex community of dynamic equilibrium microbiota, including bacteria, fungi, parasites, and viruses. It is known that the gut microbiome plays a crucial role in regulating innate and adaptive immune responses, intestinal peristalsis, intestinal barrier homeostasis, nutrient uptake, and fat distribution. The complex relationship between the host and microbiome suggests that when this relationship is out of balance, the microbiome may contribute to disease development. The brain–gut–microbial axis is composed of many signal molecules, gastrointestinal mucosal cells, the vagus nerve, and blood–brain barrier, which plays an essential role in developing many diseases. The microbiome can influence the central nervous system function through the brain–gut axis; the central nervous system can also affect the composition and partial functions of the gut microbiome in the same way. Different dietary patterns, specific dietary components, and functional dietary factors can significantly affect intestinal flora’s structure, composition, and function, thereby affecting human health. Based on the above, this paper reviewed the relationship between diet, intestinal flora, and human health, and the strategies to prevent mental illness through the dietary modification of intestinal microorganisms.

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Gut-Brain-Microbiota Axis: Antibiotics and Functional Gastrointestinal Disorders

Cited by 105 publications

References 102 publications

Dairy Lactic Acid Bacteria and Their Potential Function in Dietetics: The Food–Gut-Health Axis

Dairy Lactic Acid Bacteria and Their Potential Function in Dietetics: The Food–Gut-Health Axis

Probiotics, Photobiomodulation, and Disease Management: Controversies and Challenges

Maintaining the Balance of Intestinal Flora through the Diet: Effective Prevention of Illness

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