2003
DOI: 10.1080/10807030390251038
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Haber's Rule: The Search for Quantitative Relationships in Toxicology

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Cited by 22 publications
(3 citation statements)
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“…For selected time windows, a more generalized power law model ( C × t m = K ) rather than simple Haber’s law ( C × t = K ) yields robust predictions (Shusterman et al., 2006). For some respiratory irritants, the value of m will range from 0.3 to 1 (Bunce and Remillard, 2003). If we take a value of 0.3, the concentration not to be exceeded will be 300 μg/m 3 for 15 min and 420 μg/m 3 for 5 min.…”
Section: Discussionmentioning
confidence: 99%
“…For selected time windows, a more generalized power law model ( C × t m = K ) rather than simple Haber’s law ( C × t = K ) yields robust predictions (Shusterman et al., 2006). For some respiratory irritants, the value of m will range from 0.3 to 1 (Bunce and Remillard, 2003). If we take a value of 0.3, the concentration not to be exceeded will be 300 μg/m 3 for 15 min and 420 μg/m 3 for 5 min.…”
Section: Discussionmentioning
confidence: 99%
“…However, the slopes of the time functions were clearly better described by an individual parameter (Θ 5 ) than by the squared time. This is consistent with Haber's rule in its generalised format (Bunce and Remillard 2003) and leads to the following global concentration-time-effect model (used throughout):…”
Section: Concentration-response Relationships and Concentration-time-mentioning
confidence: 92%
“…For inhaled toxicants, m generally has a value between 0 and 1, whereas for carcinogens, m is usually between 1 and 5. The absence of a universal value for m, or one that is generally applicable to different classes of toxicants, makes it not yet possible to develop a Haber-type rule with which to extrapolate successfully between exposure scenarios (Bunce and Remillard, 2003).…”
Section: Modeling Of Dose-response Relationshipsmentioning
confidence: 99%