Hair Growth Promoting Activity of Nothopanax scutellarium Merr. Leaves

Rifkia, Via; Jufri, Mahdi; Mun’im, Abdul

doi:10.5530/jyp.2017.9.85

Cited by 4 publications

(7 citation statements)

References 16 publications

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“…Further, at week four, the weight of the rabbit was determined by pulling out and weighing the fur in each test area. Fur diameter was observed at week three using the SEM [9].…”

Section: Hair Growth Activity Testmentioning

confidence: 99%

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Formulation and Evaluation of Phytosome Lotion From Nothopanax Scutellarium Leaf Extract for Hair Growth

2021

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Objective: The purpose of this study was to formulate a phytosome lotion from Mangkokan leaf using green solvent extraction. Methods: Ionic liquid, 1-butyl-3-methylimidazolium tetrafluoroborate, combined with microwave-assisted extraction, was used to obtain flavonoid compounds. Mangkokan leaf extract was formulated into a phytosome with three different ratios of phospholipon (1:0.5), (1:1), and (1:2). Three phytosome formulas were analyzed to identify the best formula. The analysis included morphology, particle size, and zeta potential, entrapment efficiency, and spectrum analysis using an FTIR spectrophotometer. The formula which chosen was formulated into three lotion formulas with different concentration (20%; 25%; 30%) then, evaluated for physical stability, and hair growth activity test included hair length, weight, and diameter. Minoxidil and non-phytosome lotion were used as comparison. Data were analyzed using two-way ANOVA. Results: The FTIR of phytosome was confirmed a complex formation of extract and phospholipon. The phytosome morphology was displayed irregular spherical vesicles. Phytosome with the ratio of phospholipon (1:0.5) was formulated into lotion because has a smaller particle size (289 nm), and higher entrapment efficiency (99.76%±0.24) than others. Phytosome lotions displayed higher activity than 2% minoxidil (p = 0.0001). Phytosome lotion (30%) thus showed the highest efficacy for hair length, weight and diameter. Conclusion: Mangkokan leaf that extracted using 1-butyl-3-methylimidazolium tetrafluoroborate solvent combined with microwave-assisted extraction then formulated into phytosome lotion has higher activity than 2% minoxidil. Lotion that contains 30% mangkokan leaf phytosome was showed the highest efficacy.

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“…Further, at week four, the weight of the rabbit was determined by pulling out and weighing the fur in each test area. Fur diameter was observed at week three using the SEM [9].…”

Section: Hair Growth Activity Testmentioning

confidence: 99%

“…Leaf extract has known to have hair growth promoter activity in published work, but its mechanism is still unclear. Currently, flavonoids are thought to be active constituents [7][8][9]. Flavonoid was also known for antioxidant, antimicrobial, and anti-inflammatory [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Phytosome Lotion From Nothopanax Scutellarium Leaf Extract for Hair Growth

2021

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“…Then the fraction of water that had been dissolved with distilled water was entered into the initial mixture slowly while still stirring with the stirrer. Finally, propylene glycol was added and stirred with a stirrer until homogeneous [30].…”

Section: Gel and Hair Tonic Formulationmentioning

confidence: 99%

A Comparison Study of Hair Tonic and Gel Formulation of Angiopteris Evecta as a Hair Growth Stimulant

et al. 2019

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Objective: Previous research has proven that the water fraction of the Angiopteris evecta root has hair growth activities. The objective of this research was to determine the formula of gel and hair tonic preparations of pakis munding (Angiopteris evecta L.) which met the requirements as a pharmaceutical preparation, good and effective in stimulating hair growth. Methods: Formulation of hair tonic and gel preparations were made using 7.5, 10.0, and 12.5 % of A. Evecta root water extracts as active compounds. The formulation of the two preparations was based on the standard formulation method. The evaluation and formulation test were carried out by organoleptic examination and homogeneity, pH, viscosity, scattering power test, stability test, and safety test based on the standard preparations including Indonesian pharmacopeia. Statistical tests were carried out on both formulas against rabbits based on the modification of the Tanaka method. Comparison of statistics on both formulas was also carried out. Results: It was found both formulas fulfill standard requirements as pharmaceutical preparations. Statistically, the best activity in hair tonic preparations was at a concentration of 12.5% and for gels at a concentration of 10.0% ethanol extract seen from measurements of hair length. Statistically, using the Independent T-test to find out the significant differences in the average hair length on hair tonic and gel, it was found there was no significant difference between the two formulas. It was found that the best formula for hair tonic and gel was in the addition of 10.0% and 12.5% extracts, respectively. Conclusion: The results obtained in this research work clearly indicated that both hair tonic and gel formulas of A. evecta root water extract may be used as stimulating hair growth.

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“…1 Based on prior studies, mangkokan leaves can promote hair growth. [2][3][4] Although the mechanism of this effect is unclear, the activity of mangkokan leaves was believed to be attributable to its flavonoid content.…”

Section: Introductionmentioning

confidence: 99%

“…In ethanol extracts of mangkokan Leaf an average at 1.53%, in ethyl fractions acetate an average at 4.79%, and ethyl acetate extract at 1.64%, ethyl acetate fraction at 5.83%. [2][3] Several studies used ionic liquid (IL)-based microwave-assisted extraction (MAE), which has great advantages for extracting plant with high extraction levels and short extraction times. [10][11] The main advantages of MAE compared with conventional extraction techniques include the use of smaller amounts of solvents, lower costs and improved extraction quality because of the reduced degradation of thermolabile constituents.…”

Section: Introductionmentioning

confidence: 99%

Extraction of Quercetin from Nothopanax scutellarium Leaves via Ionic Liquid-based Microwave-assisted Extraction

Rahmi

Jufri²,

Mun’im³

2020

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and analyzed by the Indonesian Institute of Sciences. The leaves were washed and dried in an oven, and the dried sample was crushed using a grinder. Chemical materials and equipmentHSO 4 ), and [HMIM]Br were obtained from Shanghai Cheng Jie Chemical Co. LTD (China). Other chemicals used in this study included NaHCO 3 (Merck, Germany), K 2 HPO 4 (Merck, Germany), NaCl (Merck, Germany), ethyl acetate (Bratachem, Indonesia), methanol (Merck, Germany), glacial acetic acid (Merck, Germany), Aqua Pro Injection (PT. Ikapharmindo Putramas, Indonesia), quercetin standard (Sigma-Aldrich, Siangapore), and distilled water (CV. Satya Darmawan, Indonesia). The equipment used in the ABSTRACT Introduction: Nothopanax scutellarium leaves have been used in Indonesian traditional medicine to treat several diseases. Previous studies used conventional extraction methods with large volumes of organic solvents, long extraction times, and low levels of quercetin content. This study was aimed to identify the optimal solvent among different ionic liquids that has the highest quercetin content. Methods: Ionic liquids including 1-butyl-3-methylimidazolium bromide, 1-butyl-3-methylimidazolium tetrafluoroborate, 1-butyl-3-methylimidazolium chloride, 1-butyl-3-methylimidazolium hydrogen sulfate, and 1-hexyl-3-methylimidazolium bromide, for extracting quercetin from N. scutellarium leaves using microwave-assisted extraction under the following conditions: ratio, 1:10; operation time, 10 min; and power, 10 W. Then, quercetin was fractionated using ethyl acetate and separated using 0.01 mol/L sodium bocarbonate, dipotassium phosphate or sodium cloride. The total flavonoid content was determined using a UV-Vis spectrophotometer, and quercetin content was determined using HPLC. Results: Extraction with 1-butyl-3-methylimidazolium chloride using NaCl as the separation salt was associated with the highest total flavonoid (360.57 mg/g) content among the ILs, whereas 1-butyl-3-methylimidazolium tetrafluoroborate combined with sodium chloride generated the highest quercetin content (26.13 mg/g). Conclusion: 1-butyl-3-methylimidazolium tetrafluoroborate is the optimal solvent for extracting quercetin from N. scutellarium leaves.

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Hair Growth Promoting Activity of Nothopanax scutellarium Merr. Leaves

Cited by 4 publications

References 16 publications

Formulation and Evaluation of Phytosome Lotion From Nothopanax Scutellarium Leaf Extract for Hair Growth

Formulation and Evaluation of Phytosome Lotion From Nothopanax Scutellarium Leaf Extract for Hair Growth

A Comparison Study of Hair Tonic and Gel Formulation of Angiopteris Evecta as a Hair Growth Stimulant

Extraction of Quercetin from Nothopanax scutellarium Leaves via Ionic Liquid-based Microwave-assisted Extraction

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