HDL-sphingomyelin reduction after weight loss by an energy-restricted diet is associated with the improvement of lipid profile, blood pressure, and decrease of insulin resistance in overweight/obese patients

Martínez-Ramírez, Miriam; Madero, Magdalena; Vargas‐Alarcón, Gilberto; Vargas-Barrón, Jesús; Fragoso, José Manuel; Rodríguez-Pérez, José Manuel; Martínez‐Sánchez, Carlos; González‐Pacheco, Héctor; Bautista-Pérez, Rocı́o; Carreón‐Torres, Elizabeth; Pérez-Méndez, Óscar

doi:10.1016/j.cca.2015.12.039

Cited by 20 publications

(17 citation statements)

References 34 publications

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“…Previous studies have reported a decreased serum or plasma sphingomyelin concentration after weight loss in humans ( 34 , 35 ). We could not confirm any linear relationship between sphingomyelin and body weight in all our patients, except for weak correlations at 12 and 24 months after surgery, where a higher body weight was associated to a lower sphingomyelin concentration.…”

Section: Discussionmentioning

confidence: 89%

Changes in Serum Sphingomyelin After Roux-en-Y Gastric Bypass Surgery Are Related to Diabetes Status

et al. 2018

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Metabolic surgery is superior to lifestyle intervention in reducing weight and lowering glycemia and recently suggested as treatment for type 2 diabetes mellitus. Especially Roux-en-Y gastric bypass (RYGB) has been focus for much research, but still the mechanisms of action are only partly elucidated. We suggest that several mechanisms might be mediated by sphingolipids like sphingomyelin. We measured serum sphingomyelin before and up to 2 years after RYGB surgery in 220 patients, divided before surgery in one non-diabetic subgroup and two diabetic subgroups, one of which contained patients obtaining remission of type 2 diabetes after RYGB, while patients in the other still had diabetes after RYGB. Pre- and postoperative sphingomyelin levels were compared within and between groups. Sphingomyelin levels were lower in diabetic patients than in non-diabetic patients before surgery. Following RYGB, mean sphingomyelin concentration fell significantly in the non-diabetic subgroup and the preoperative difference between patients with and without diabetes disappeared. Changes in diabetic subgroups were not significant. Relative to bodyweight, an increase in sphingomyelin was seen in all subgroups, irrespective of diabetes status. We conclude that RYGB has a strong influence on sphingomyelin metabolism, as seen reflected in changed serum levels. Most significantly, no differences between the two diabetic subgroups were detected after surgery, which might suggest that patients in both groups still are in a “diabetic state” using the non-diabetic subgroup as a reference.

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Section: Discussionmentioning

confidence: 89%

Changes in Serum Sphingomyelin After Roux-en-Y Gastric Bypass Surgery Are Related to Diabetes Status

et al. 2018

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“…Oxidized SMs enhance the susceptibility of HDL to aggregation and accumulation in the arterial walls [ 43 ] and reduce their clearance. A recent study reported that weight loss after a hypocaloric-diet intervention was associated with a decrease of HDL-SM, together with an improvement of the metabolic status [ 43 ]. The different post-surgery metabolic profiles of phenotypes 1 and 2 suggest that the benefits from the bariatric surgery are phenotypically dependent.…”

Section: Discussionmentioning

confidence: 99%

Metabotypes of response to bariatric surgery independent of the magnitude of weight loss

et al. 2018

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ObjectiveBariatric surgery is considered the most efficient treatment for morbid obesity and its related diseases. However, its role as a metabolic modifier is not well understood. We aimed to determine biosignatures of response to bariatric surgery and elucidate short-term metabolic adaptations.MethodsWe used a LC- and FIA-ESI-MS/MS approach to quantify acylcarnitines, (lyso)phosphatidylcholines, sphingomyelins, amino acids, biogenic amines and hexoses in serum samples of subjects with morbid obesity (n = 39) before and 1, 3 and 6 months after bariatric surgery. K-means cluster analysis allowed to distinguish metabotypes of response to bariatric surgery.ResultsFor the first time, global metabolic changes following bariatric surgery independent of the baseline health status of the subjects have been revealed. We identify two metabolic phenotypes (metabotypes) at the interval 6 months-baseline after surgery, which presented differences in the levels of compounds of urea metabolism, gluconeogenic precursors and (lyso)phospholipid particles. Clinically, metabotypes were different in terms of the degree of improvement in insulin resistance, cholesterol, low-density lipoproteins and uric acid independent of the magnitude of weight loss.ConclusionsThis study opens new perspectives and new hypotheses on the metabolic benefits of bariatric surgery and understanding of the biology of obesity and its associated diseases.

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“…In contrast to the general phosphatidylcholine levels, two sphingomyelins [18:0 SM and SM(24:1)] and one phosphatidylcholine isoform [PC(40:4)] were reduced at weaning in dams from the current study. Overweight humans consuming an energy-restricted diet experienced weight loss, decreased levels of sphingomyelins, and ameliorated metabolic syndrome (Martinez-Ramirez et al, 2016). Additionally sphingolipids, which include sphingomyelins, are known to influence steroid hormone production by regulating components of the biosynthesis pathway (Lucki and Sewer, 2008).…”

Section: Discussionmentioning

confidence: 99%

Non-targeted Plasma Metabolome of Early and Late Lactation Gilts

Rempel

Miles

Oliver

et al. 2016

Front. Mol. Biosci.

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Female pigs nursing their first litter (first-parity gilts) have increased energy requirements not only to support their piglets, but they themselves are still maturing. Non-targeted plasma metabolomics were used to investigate the differences between (1) post-farrowing and weaning (early or late lactation), (2) degree of body condition loss after lactation (extreme or minimal), and (3) interactions; to potentially identify compounds or pathways that could aide in alleviating energetic demands of lactation in gilts. Twenty first-parity gilts were selected with similar (P ≥ 0.4475) number of piglets born and nursed, and similar (P ≥ 0.3141) body condition traits (e.g., body weight and backfat thickness) post-farrowing, yet exhibited minimal or extreme loss (P ≤ 0.0094) in body weight (8.6 ± 1.48 kg and 26.1 ± 1.90 kg, respectively) and backfat thickness (1.3 ± 0.67 mm and 4.7 ± 0.86 mm, respectively) following lactation (weaning). Plasma samples from first-parity gilts at post-farrowing and weaning were investigated using UPLC-MS and GC-MS to generate a comprehensive metabolic profile. Each approach yielded approximately 700 detected features. An ANOVA was performed on each detected compound in R for time of collection, body condition change, and the interaction, followed by a false discovery correction. Two unknown features were different (P ≤ 0.05) for extreme vs. minimal body condition change. Several compound differences (P ≤ 0.05) were identified between post-farrowing and weaning. Thirty-two features detected by UPLC-MS had at least a log2 fold-change of ±1.0 while only 18 features had a log2 fold-change of ±0.6 or more for the significant GC-MS features. Annotation implicated various metabolic pathways. Creatinine was greater at weaning (P = 0.0224) and others have reported increased serum concentrations of creatinine in response to body weight loss. Hippurate and caprolactam, associated with protein catabolism, were also greater (P ≤ 0.0166) at weaning. Phospholipid features (P ≤ 0.0347) and inositol-related features (P ≤ 0.0236) were also greater at weaning. Inositol features may exert insulin-like effects. The energetic demands of lactation in gilts nursing their first litter indicated a greater difference exists between early and late lactation regardless of body condition loss.

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HDL-sphingomyelin reduction after weight loss by an energy-restricted diet is associated with the improvement of lipid profile, blood pressure, and decrease of insulin resistance in overweight/obese patients

Cited by 20 publications

References 34 publications

Changes in Serum Sphingomyelin After Roux-en-Y Gastric Bypass Surgery Are Related to Diabetes Status

Changes in Serum Sphingomyelin After Roux-en-Y Gastric Bypass Surgery Are Related to Diabetes Status

Metabotypes of response to bariatric surgery independent of the magnitude of weight loss

Non-targeted Plasma Metabolome of Early and Late Lactation Gilts

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