Heat Shock Protein 27 (HSP27) As a Therapeutic Target in Ischemic Stroke and Neurodegenerative Disorders

Shimura, Hideki; Tanaka, Ryota; Urabe, Takao

doi:10.14789/jmj.63.17

Cited by 3 publications

(3 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Overexpressing HSP27 in HSP27 transgenic mice prevented cells from suffering further neuronal damage by preventing ASK1-dependent MKK4/JNK activation (23). Intravenous injection of HSP27 in the MCAO mouse model also showed inhibition of apoptosis and inflammatory responses (7). However, the antioxidant benefits that HSP27 has to exist during its large oligomeric conditions (24).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The effect of extra virgin olive oil on HSP27 expression in the cerebral cortex of male Rattus norvegicus middle cerebral artery occlusion model

Machin,

Kalanjati,

Abidah

et al. 2024

Food & Nutrition Research

View full text Add to dashboard Cite

Background: Ischemic stroke produces oxidative stress in neurons and neuroglial, triggering a cellular response with HSP27 as one of the markers. Extra virgin olive oil (EVOO) is reported to act as a neuroprotection by inhibiting reactive oxygen species, which can modulate HSP27. Objective: To analyze the potential neuroprotection of EVOO containing 7-g MUFA on the expression of HSP27 in the cerebral cortex of Rattus norvegicus Wistar strain middle cerebral artery occlusion (MCAO) model. Design: MCAO-Rattus norvegicus Wistar male rodents (n = 32), randomly divided into negative control (sham), positive control (P0), MCAO added EVOO 0.5 mL/kg body weight (P1), and MCAO added EVOO 2 mL/kg body weight (P2); the experiment was conducted 14 days. The nuclei of neurons, glial, and expression of HSP27 on the cerebral cortex were analyzed using Image J software, data were compared between groups with a significance level of P < 0.05. Results: There were significant differences in the neuron and glia nuclei numbers between groups (P = 0.01). There was also a significant difference in cerebral cortex HSP27 expression between groups (P = 0.006). Conclusion: There was a significant down-regulated of HSP27 in the cerebral cortex of the male Rattus norvegicus Wistar strain MCAO model given EVOO with 7 g of MUFA content at a dose of 0.5–2 mL/kgBW.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Heat shock protein 27 (HSP27) can function as an antioxidant by increasing intracellular glutathione levels to reduce ROS (7). HSP27, under stress conditions, will interact with phosphatidylinositol 3-kinase (PI3-K), which can increase the expression of protein kinase B (Akt).…”

mentioning

confidence: 99%

The effect of extra virgin olive oil on HSP27 expression in the cerebral cortex of male Rattus norvegicus middle cerebral artery occlusion model

Machin,

Kalanjati,

Abidah

et al. 2024

Food & Nutrition Research

View full text Add to dashboard Cite

show abstract

“…Based on the result that has been reported intravenously administration of HSP27 showed protection of the brain in different stroke rat models. 98 The authors claim that they did not observe any significant adverse effect of HSP27. Further studies are needed in order to develop HSP27 intravenous therapy for the treatment of stroke.…”

Section: Therapeutical Targeting/inhibitionmentioning

confidence: 98%

Impact of Heat Shock Proteins in Neurodegeneration: Possible Therapeutical Targets

Beretta

Shala

2022

Annals of Neurosciences

View full text Add to dashboard Cite

Human neurodegenerative diseases occur as a result of various factors. Regardless of the variety in the etiology of development, many of these diseases are characterized by the accumulation of pathological, misfolded proteins; hence, such diseases are considered as proteinopathies. While plenty of research study has been conducted in order to identify the pathophysiology of these proteinopathies, there is still a lack of understanding in terms of potential therapeutic targets. Molecular chaperones present the main workforce for cellular protection and stress response. Therefore, considering these functions, molecular chaperones present a promising target for research within the field of conformational diseases that arise from proteinopathies. Since the association between neurodegenerative disorders and their long-term consequences is well documented, the need for the development of new therapeutic strategies becomes even more critical. In this review, we summarized the molecular function of heat shock proteins and recent progress on their role, involvement, and other mechanisms related to neurodegeneration caused by different etiological factors. Based on the relevant scientific data, we will highlight the functional classification of heat shock proteins, regulatin, and their therapeutic potential for neurodegenerative disorders.

show abstract

Heat Shock Proteins in Oxidative and Nitrosative Stress

Kattaia

El-Baset

Mohamed

2018

Heat Shock Proteins

View full text Add to dashboard Cite

Heat Shock Protein 27 (HSP27) As a Therapeutic Target in Ischemic Stroke and Neurodegenerative Disorders

Cited by 3 publications

References 33 publications

The effect of extra virgin olive oil on HSP27 expression in the cerebral cortex of male Rattus norvegicus middle cerebral artery occlusion model

The effect of extra virgin olive oil on HSP27 expression in the cerebral cortex of male Rattus norvegicus middle cerebral artery occlusion model

Impact of Heat Shock Proteins in Neurodegeneration: Possible Therapeutical Targets

Heat Shock Proteins in Oxidative and Nitrosative Stress

Contact Info

Product

Resources

About