Helical nanobots as mechanical probes of intra- and extracellular environments

Pal, Malay; Dasgupta, Debayan; Somalwar, Neha; Vr, Reshma; Tiwari, Mayank; Teja, Dharma; Narayana, Suma Mysore; Katke, Aradhana; Rs, Jayshree; Bhat, Ramray; Saini, Deepak Kumar; Ghosh, Ambarish

doi:10.1088/1361-648x/ab6f89

Cited by 42 publications

(37 citation statements)

References 57 publications

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“…However, motion of helical magnetic nanorobots was successfully explored in Hela, kidney, and endothelial cells environments after incubation and internalization. [ 359 ] This robotic intracellular probe approach was also demonstrated to measure viscosity, [ 360 ] and adhesive forces inside metastatic cancer cells. [ 361 ] Piezoelectric microrobots were also reported as wireless probes for neural stimulation mapping and differentiation of single cell using the piezoelectric effect produced by an external ultrasound field.…”

Section: Diagnosismentioning

confidence: 99%

Medical Micro/Nanorobots in Precision Medicine

et al. 2020

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Advances in medical robots promise to improve modern medicine and the quality of life. Miniaturization of these robotic platforms has led to numerous applications that leverages precision medicine. In this review, the current trends of medical micro and nanorobotics for therapy, surgery, diagnosis, and medical imaging are discussed. The use of micro and nanorobots in precision medicine still faces technical, regulatory, and market challenges for their widespread use in clinical settings. Nevertheless, recent translations from proof of concept to in vivo studies demonstrate their potential toward precision medicine.

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Section: Diagnosismentioning

confidence: 99%

Medical Micro/Nanorobots in Precision Medicine

et al. 2020

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“…It was observed that at the site of injection of nanorobots many of them got adhered to the glass slide. The presence of local pockets of injected fluids has been reported in a previous literature 69 , where it was shown that within a time scale of approximately 30 minutes, the system gains its structural uniformity.…”

Section: D Culture and Experimental Procedurementioning

confidence: 54%

Nanorobots Sense Local Physiochemical Heterogeneities of Tumor Matrisome

Dasgupta¹,

Pally²,

Saini³

et al. 2020

Preprint

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The dissemination of cancer is brought about by continuous interaction of malignant cells with their surrounding tissue microenvironment. Understanding and quantifying the remodeling of local extracellular matrix (ECM) by invading cells can therefore provide fundamental insights into the dynamics of cancer dissemination. In this paper, we use an active and untethered nanomechanical tool, realized as magnetically driven nanorobots, to locally probe a 3D tissue culture microenvironment consisting of cancerous and non-cancerous epithelia, embedded within reconstituted basement membrane (rBM) matrix. Our assay is designed to mimic the in vivo histopathological milieu of a malignant breast tumor. We find that nanorobots preferentially adhere to the ECM near cancer cells: this is due to the distinct charge conditions of the cancer-remodeled ECM. Surprisingly, quantitative measurements estimate that the adhesive force increases with the metastatic ability of cancer cell lines, while the spatial extent of the remodeled ECM was measured to be approximately 40 μm for all cancer cell lines studied here. We hypothesized and experimentally confirmed that specific sialic acid linkages specific to cancer-secreted ECM may be a major contributing factor in determining this adhesive behavior. The findings reported here can lead to promising applications in cancer diagnosis, quantification of cancer aggression, in vivo drug delivery applications, and establishes the tremendous potential of magnetic nanorobots for fundamental studies of cancer biomechanics.

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“…[ 144 ] Magnetic helical nanorobots as mechanical probes realized accurate measurement of cytoplasmic viscosity of HeLa cell. [ 155 ]…”

Section: Versatile Biomedical Applications Of Magnetic Micro/nanorobotsmentioning

confidence: 99%

Engineering Magnetic Micro/Nanorobots for Versatile Biomedical Applications

Wang

Meng

Chen

et al. 2021

Advanced Intelligent Systems

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With the rapid development of micro/nanomanufacturing technology, a variety of multifunctional micro/nanorobots have emerged. In particular, magnetic actuation-based micro/nanorobots have attracted much interest due to their advantages of untethered contact, remote control, noninvasiveness, and high tissue-penetrating capability. Various magnetic micro/nanorobots have been designed and applied in biomedicine, which indicates the great potential of clinical transformation. This article reviews the new advancements of engineering magnetic micro/nanorobots for versatile biomedical applications, ranging from targeted delivery, minimally invasive surgery, cellular and intracellular measurement, and intelligent sensing to detoxification and antibacterial applications. The controllability, visualization, and biosafety aspects of magnetically manipulated micro/nanorobots are summarized. In particular, the challenges being faced are discussed to outlook future prospective development.

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Helical nanobots as mechanical probes of intra- and extracellular environments

Abstract: Supporting information1. Dynamics of helical nanobots under rotating magnetic fields A helical nanorobot actuated under rotating magnetic field shows different kind of dynamics depending upon the applied field, frequency and the fluid viscosity. This difference in dynamics

Cited by 42 publications

References 57 publications

Medical Micro/Nanorobots in Precision Medicine

Medical Micro/Nanorobots in Precision Medicine

Nanorobots Sense Local Physiochemical Heterogeneities of Tumor Matrisome

Engineering Magnetic Micro/Nanorobots for Versatile Biomedical Applications

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