Helicobacter Pylori Associated Chronic Gastritis and Application of Visual Analogue Scale for the Grading of the Histological Parameters in Nepal

Maharjan, Sushna

doi:10.26717/bjstr.2017.01.000108

Cited by 4 publications

(11 citation statements)

References 25 publications

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“…Similar to these results Udoh 2012 [10] also reported chronic gastritis cases in younger age group with mean age of 48.6 years. Data obtained from this study showed that around two third of the sample were female, which is in a good accordance with results produced by Shahram [11], who reported that female rate were significantly higher than male rates, similarly in [12] study the prevalence of H. pylori infection in female were 52% was higher as compared by male patients. In contrast to these observations a higher incidence was seen in males with a male: female ratio of 2.1: 1 [13].…”

Section: Discussionsupporting

confidence: 91%

Evaluation of Invasive and Non-Invasive Methods for the Diagnosis of H. pylori in Dyspepsia Patients

Mawlood¹,

Kawther²,

Balaky³

2019

DJM

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Background: H. pylori has been established as the major causative agent of chronic gastritis, and represents the main etiological cause of other gastroduodenal diseases such as peptic ulceration, gastric lymphoma, and gastric cancer. Therefore, screening and treatment of the bacterium is an important strategy for preventing gastric cancer. Objective: To compare some invasive classical histological tests to non-invasive serological antibody and stool antigen tests for the diagnosis of H. pylori infections. Patients and Methods:The study population comprised of 171 patients with symptoms of dyspepsia and other gastritis related symptoms. Three biopsy specimens were taken and collected from the stomach and sent for histopathologic study. H and E staining and modified Giemsa staining were performed on tissue sections of each case. Serology antibody and Stool antigen tests were also used as nan-invasive tests in this study. Results: Four tests had been done to detect the presence of H. pylori Bacteria. The mean age (+ SD) of the studied sample was 43.8 + 14.7 years, ranging from 20 to 74 years. The median was 44 years. The total agreement between the serum Ab test and the stool Ag test was 88.3%. Significant differences were detected between the two tests (p < 0.001). It is evident that the serum Ab test is highly sensitive (sensitivity = 98.4%), but the Predictive value positive (76.3%) was not so high. The Giemsa test was highly specific (specificity = 98.2%), and highly sensitive (sensitivity = 93.5%). Conclusion: The main advantage of histopathology tests is not only restricted to detection purpose, it also can detect any abnormalities of gastric mucosa by bacteria such as peptic ulcer bleeding, atrophic gastritis, intestinal metaplasia, and gastric cancer. The modified Giemsa staining method could be used as a method of choice for the detection of H. pylori due to its sensitivity, simplicity and consistency.

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Section: Discussionsupporting

confidence: 91%

Evaluation of Invasive and Non-Invasive Methods for the Diagnosis of H. pylori in Dyspepsia Patients

Mawlood¹,

Kawther²,

Balaky³

2019

DJM

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“… 7 , 8 , 15 Majority of inflammation in this study were of moderate grade (48.8%) followed by mild 42% and marked 9.6%, which is similar to the other studies. 8 , 14 , 15 In contrary to this, a study by Garg et.al found that majority of inflammation was mild. 7 Moreover H. pylori was detected in 150 (60%) cases of Chronic gastritis that is consistent with a previous study.…”

Section: Discussionmentioning

confidence: 78%

“… 7 , 8 , 12 , 13 However, this finding is contrary to the study by Maharjan et al, where females were found to have a higher rate of H. pylori infection . 14 …”

Section: Discussionmentioning

confidence: 99%

“… 7 Moreover H. pylori was detected in 150 (60%) cases of Chronic gastritis that is consistent with a previous study. 14 …”

Section: Discussionmentioning

confidence: 99%

“… 8 , 15 However, the result in the present study outnumbered the observation of previous studies by Garg et al (33.33 % ), Hassan et al (31.84%), and Maharjan et al (33.6%). 7 , 10 , 14 …”

Section: Discussionmentioning

confidence: 99%

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Prevalence of Helicobacter Pylori in Endoscopic Gastric Biopsies of Chronic Gastritis Patients at A Tertiary Care Centre

et al. 2020

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Introduction: Presence and severity of Helicobacter pylori (H. pylori) colonization is an important factor to decide the treatment of chronic gastritis. This study aimed to find the prevalence of H. pylori colonization in chronic gastritis patients. Methods: This descriptive,cross-sectional study was carried out at the tertiary care center in the the western region of Nepal among the dyspeptic patients undergoing endoscopic gastric biopsy from October 2018 to March 2020 after approval from the Institutional review committee. Convenience sampling was done to reach the sample size. Two hundred fifty cases were included in the study. Data were recorded in proforma and Data analysis was done in the statistical package for social sciences (SPSS 16.0). The severity of H. pylori colonization and gastritis was graded using the Updated Sydney System. Results: All cases showed chronic gastritis on histopathology. H. pylori were seen in 150 (60%) of cases. Mild, moderate, and severe H. pylori infection was seen in 59, 78, and 13 cases respectively. Out of 59 mild H. pylori cases, 35 (59.32%) had mild chronic inflammation; out of 78 moderate H. pylori cases 51 (65.38%) had moderate chronic inflammation and among 13 severe H. pylori cases, 10 (76.92%) had severe chronic inflammation. Conclusions: Prevalence of H. pylori colonization is high in chronic gastritis and there is a parallel increase in the severity of gastritis with an increase in the severity of H. pylori load.

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Prevalence of Atrophic Gastritis in Symptomatic Patients Undergoing Gastric Biopsy in a Tertiary Care Center of Nepal

Ranjan

Poudyal

Neupane

et al. 2023

JCMC

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Background: Atrophic gastritis and intestinal metaplasia are precancerous conditions associated with Helicobacter pylori infection. The prevalence of these conditions varies among countries and even among different regions in same country. There is limited data from central Nepal regarding these entities. The primary aim of this study was to assess the prevalence of atrophic gastritis in gastric biopsy of symptomatic patients. Methods: A prospective study which included all consecutive patients undergoing endoscopic gastric biopsy. Biopsies from body and antrum obtained as per Sydney protocol. Histopathological examination was done by a team of histopathologists and reported according to updated Sydney classification. Statistical software SPSS (version 26, SPSS Inc. Chicago, IL) and STATA 14 were used for statistical analysis. Results: Of 113 consecutive patients, 103 were included for final analysis (female: 59.2% and mean age: 46.29 ± 16.54 years). Dyspepsia [EPS: 69 (66.9%) and PDS:19 (18.4%)] followed by GERD in 21 (20.3%) were the commonest presentations. On histology, atrophic gastritis was present in 101 (98.05%) patients with mild-, moderate-, and severe AG seen in 12 (11.8%), 87 (86.1%), and 2 (1.9%) respectively. Prevalence of AG was not different in patients with or without H. pylori infection (p=0.10). Intestinal metaplasia was present in 13 (12.62%). Helicobacter pylori were present in 58 (56.3%) with prevalence in antrum and body being 57 (55.3%) vs. 41 (39.8%), p=0.02. Conclusions: Atrophic gastritis, IM, and H. pylori infection is highly prevalent in symptomatic patients and the prevalence in younger population is equally high compared to older population.

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Helicobacter Pylori Associated Chronic Gastritis and Application of Visual Analogue Scale for the Grading of the Histological Parameters in Nepal

Cited by 4 publications

References 25 publications

Evaluation of Invasive and Non-Invasive Methods for the Diagnosis of H. pylori in Dyspepsia Patients

Evaluation of Invasive and Non-Invasive Methods for the Diagnosis of H. pylori in Dyspepsia Patients

Prevalence of Helicobacter Pylori in Endoscopic Gastric Biopsies of Chronic Gastritis Patients at A Tertiary Care Centre

Prevalence of Atrophic Gastritis in Symptomatic Patients Undergoing Gastric Biopsy in a Tertiary Care Center of Nepal

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