Hemangioendothelioma with intravascular coagulation and ischemic colitis

Weinblatt, Mark E.; Kahn, Ellen; Kochen, Joseph

doi:10.1002/1097-0142(19841115)54:10<2300::aid-cncr2820541041>3.0.co;2-0

Cited by 17 publications

(5 citation statements)

References 24 publications

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“…The clinical and histopathological features of our case are very similar to those previously reported as Kaposiform haemangioendothelioma [1][2][3][4][5] . This case lacked epithelioid endothelial cells, haemosiderin, hyaline globules, and cytoplasmic vacuolation of endothelial cells, which were identified in some cases described by Zukerberg et al 1 .…”

Section: Discussionsupporting

confidence: 86%

“…Kaposiform haemangioendothelioma is a very rare, but distinctive, vascular tumour first described by Zukerberg et al 1 . However, several similar tumours have been reported under a variety of names including Kaposi-like infantile haemangioendothelioma 2 , locally metastasizing vascular tumour 3 , haemangioma with Kaposi sarcoma-like features 4 , or simply haemangioendothelioma 5 . It usually occurs in the retroperitoneum, skin, or soft tissue of infants [1][2][3][4][5] .…”

Section: Introductionmentioning

confidence: 99%

“…However, several similar tumours have been reported under a variety of names including Kaposi-like infantile haemangioendothelioma 2 , locally metastasizing vascular tumour 3 , haemangioma with Kaposi sarcoma-like features 4 , or simply haemangioendothelioma 5 . It usually occurs in the retroperitoneum, skin, or soft tissue of infants [1][2][3][4][5] . This lesion is often complicated by Kasabach-Merritt syndrome of consumptive thrombocytopenia or coagulopathy associated with a vascular neoplasm 6 , lymphangiomatosis, obstructive jaundice, or intestinal obstruction.…”

Section: Introductionmentioning

confidence: 99%

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Kaposiform haemangioendothelioma associated with Kasabach‐Merritt syndrome

1996

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Kaposiform haemangioendothelioma associated with Kasabach‐Merritt syndrome

1996

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“…Inceman and Tangun, 12 in 1969, and Weinblatt et al . 13 in 1984, reported cases of giant hemangiomas associated with chronic disseminated intravascular coagulation and microangiopathic hemolytic anemia.…”

Section: Discussionmentioning

confidence: 99%

Kasabach–Merritt syndrome in two successive pregnancies

Singh

Rajendran

1998

Int J Dermatology

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A 20‐year‐old Indian Hindu woman, a primigravida at 8 months of pregnancy, presented with symptoms of progressively worsening dyspnea and anasarca of 1 month duration. Physical examination showed signs of severe congestive cardiac failure. She had multiple hemangiomas, 5 cm in size, located over the right temporal region, right side of the chin, right side of the nose, left upper part of the abdominal wall, and anterior aspect of the left leg ( Fig. 1). These hemangiomas had been present since birth and had enlarged considerably during pregnancy. The clinical diagnosis was pregnancy—34 weeks—with multiple hemangiomas and congestive cardiac failure. 1 Hemangiomas Laboratory investigations revealed hemoglobin (Hb) 11 g/dL, total leucocyte count 7000/mm3, differential count P 60 L 40, random blood sugar 110 mg/dL, blood urea (BU) 34 mg/dL, creatinine 0.9 mg/dL, and serum electrolytes: Na, 130 mEq/L; K, 4 mEq/L; Cl, 110 mEq/L. Electrocardiogram (ECG) was normal. Chest X‐ray showed cardiomegaly with congestion. Echocardiogram (ECHO) showed enlarged right atrium and right ventricle. The patient was refractory to antifailure therapy and went into labor at the end of 35 weeks of pregnancy and delivered a 1.3 kg male baby. The patient developed post partum hemorrhage and was treated with blood transfusion. During labor, the patient developed purpuric eruption and epistaxis. At that time, the bleeding time was more than 15 min and the platelet count was 46,000. At this juncture, a diagnosis of Kasabach–Merritt syndrome was considered. Skin biopsy revealed hemangiomatous changes. After delivery, the patient’s edema and dyspnea decreased considerably and the eruption disappeared. The hemangiomas regressed in size. A platelet count performed 3 days after delivery was 120,000/mm3. The bleeding time was 7 min, and a chest X‐ray showed the reduction of heart size to normal. ECHO repeated 1 week after delivery showed normal‐sized chambers. Follow‐up as an outpatient showed the patient returning to normalcy. She had a similar presentation during her second pregnancy, 1 year later.

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“…KHE demonstrates locally aggressive behaviour but cutaneous forms usually have good prognosis. Lesions on the trunk or proximal extremities have a higher incidence of lymphangiomatosis and Kasabach–Meritt syndrome, whereas those limited to distal extremities are benign and easily cured with surgical excision 2,3 …”

Section: Clinical Characteristics Of Adult Patients With Khe Reportedmentioning

confidence: 99%

Kaposiform hemangioendothelioma in an adult with an unusual presentation

Şentürk¹,

Yýldiz²,

Aydin³

et al. 2006

Acad Dermatol Venereol

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detectable by PCR in PBMC. If such is indicative of active infection, 30% of healthy individuals would be having active HHV-7 infection at any one time point.In summary, we compliment Vág et al. in having reported a high-quality study with a novel approach, but are unconvinced that their results provide conclusive evidence of recent primary HHV-7 infection in young adults with PR. References1 Vág T, Sonkoly E, Kárpáti S, Kemény B, Ongrádi J. Avidity of antibodies to human herpesvirus 7 suggests primary infection in young adults with pityriasis rosea. J Eur Acad Dermatol Venereol 2004; 18: 738 -740. 2 Kosuge H, Tanaka-Taya K, Miyoshi H et al. Epidemiological study of human herpesvirus-6 and human herpesvirus-7 in pityriasis rosea. Br J Dermatol 2000; 143: 795-798. 3 Yasukawa M, Sada E, Machino H, Fugita S. Reactivation of human herpesvirus 6 in pityriasis rosea. Br J Dermatol 1999; 140: 169 -170. 4 Chuh AAT, Chiu SSS, Peiris JSM. Human herpesvirus 6 and 7 DNA in peripheral blood leukocytes and plasma in patients with pityriasis rosea by polymerase chain reaction -a prospective case control study. Acta Derm Venereol 2001; 81: 289-290. 5 Chan PK, Peiris JS, Yuen KY et al. Human herpesvirus-6 and human herpesvirus-7 infections in bone marrow transplant recipients. J Med Virol 1997; 53: 295 -305. 6 Vág T, Sonkoly E, Kemeny B et al. [Studies on the novel association of human herpesvirus-7 with skin diseases.].

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Hemangioendothelioma with intravascular coagulation and ischemic colitis

Cited by 17 publications

References 24 publications

Kaposiform haemangioendothelioma associated with Kasabach‐Merritt syndrome

Kaposiform haemangioendothelioma associated with Kasabach‐Merritt syndrome

Kasabach–Merritt syndrome in two successive pregnancies

Kaposiform hemangioendothelioma in an adult with an unusual presentation

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