Hemodialysis membranes prepared from poly(vinyl alcohol): Effects of the preparation conditions on the morphology and performance

Barzin, Jalal; Madaeni, S.S.; Pourmoghadasi, S.

doi:10.1002/app.25627

Cited by 24 publications

(18 citation statements)

References 24 publications

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“…Heparin that has negative charges of sulfonate or sulfate groups, has been suggested as an T. Hayashita is with the Department of Materials and Science, Faculty of Science and Technology, Sophia University, Tokyo, Japan. effective way to reduce protein adsorption by chitosan [2], [3].…”

Section: Introductionmentioning

confidence: 99%

“…Several routes can be used to change the surface of chitosan, the key purpose of which is to alter the chemical composition and the surface properties of chitosan to suit specific application [3]- [7]. For the purpose of this research, the modification of chitosan was conducted especially to prevent the interaction between protein and the membrane surface, so that the surface no longer exhibits positive charge.…”

Section: Introductionmentioning

confidence: 99%

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Permeability of Urea in N-Carboxymethyl Chitosan-Poly (Vynilalcohol) Blend Membranes for Hemodialysis

Lusiana¹,

Siswanta²,

Mudasir³

et al. 2013

IJCEA

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Abstract-A series of membranes are prepared by solvent drying method, which were composed of N-carboxymehtyl chitosan blended with poly(vinyl alcohol) [N-CMC/PVA]. The N-CMC/PVA membranes showed improved strength properties and permeability for low-molecular weight compounds. This novel membranes exhibited good permeability properties for small molecules also indicated a decrease in protein adsorption on the surface of membrane. The structure and the morphology of the resulting membranes were characterized by FTIR. NMR, elementary analysis and scanning electron microscopy (SEM).

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Permeability of Urea in N-Carboxymethyl Chitosan-Poly (Vynilalcohol) Blend Membranes for Hemodialysis

Lusiana¹,

Siswanta²,

Mudasir³

et al. 2013

IJCEA

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“…Practically, physical PVA hydrogels show a good biocompatibility, which makes them of high interest to the biomedical field. They have been widely studied as a constitutive material for biomembranes (15,16), cell encapsulation (17,18), or soft-tissue reconstruction (4,19). In that respect, several methods have been developed to induce the gelation of PVA, using solvent evaporation (20), thermal treatments by freezing-thawing (19), coagulation in poor solvent (15), or salting out (21).…”

Section: Significancementioning

confidence: 99%

Hydrogel films and coatings by swelling-induced gelation

Moreau

Chauvet

François

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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Hydrogel films used as membranes or coatings are essential components of devices interfaced with biological systems. Their design is greatly challenged by the need to find mild synthesis and processing conditions that preserve their biocompatibility and the integrity of encapsulated compounds. Here, we report an approach to produce hydrogel films spontaneously in aqueous polymer solutions. This method uses the solvent depletion created at the surface of swelling polymer substrates to induce the gelation of a thin layer of polymer solution. Using a biocompatible polymer that self-assembles at high concentration [poly(vinyl alcohol)], hydrogel films were produced within minutes to hours with thicknesses ranging from tens to hundreds of micrometers. A simple model and numerical simulations of mass transport during swelling capture the experiments and predict how film growth depends on the solution composition, substrate geometry, and swelling properties. The versatility of the approach was verified with a variety of swelling substrates and hydrogel-forming solutions. We also demonstrate the potential of this technique by incorporating other solutes such as inorganic particles to fabricate ceramic-hydrogel coatings for bone anchoring and cells to fabricate cell-laden membranes for cell culture or tissue engineering. H ydrogel films are used in a number of biomedical applications like wound healing (1), drug delivery (1), antiadhesive membranes (2), soft-tissue reconstruction (3, 4), and cell culture (5). The quality of their interactions with biological tissues or entrapped cells is central to the performance of these systems. Although considerable advances have been made in synthesis (6) and processing (7) to tailor these interactions, the toxicity of by-products and the degradation caused by harsh processing conditions remain key issues (8), which can be overcome (9) but are often addressed at the cost of difficult synthesis or multistep processes. There is a great interest for simple, versatile, and in vivo-friendly methods to fabricate and modify hydrogels. We propose a strategy to design hydrogel films in mild conditions. This method could be used to produce freestanding hydrogel membranes or hydrogel coatings to functionalize other hydrogels.Our approach relies on the understanding of transport phenomena occurring near the surface of a polymer network swelling in a polymer solution. As an illustration, let us consider a flat polymer network with thickness H 0 immersed in a solution containing a volume fraction Φ 0 of free polymer chains, as depicted in Fig. 1A. When the solvent of the solution is also a solvent for the network, the network swells in a diffusive process. For early immersion times t, the increase in thickness ΔH is given by the following (10, 11):where H ∞ is the thickness at equilibrium swelling in the polymer solution and D 0 is a diffusivity coefficient depending on the dynamics of the network and of the solution. The systems of interest are those where the chains in solution do not penetrate...

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“…PVA is a hydrophilic, elastic, non-toxic, no carcinogenic and biodegradable polymer [6]. The combination between PVA and chitosan can be used as a basic material to prepare hemodialysis membrane [7]. The combination of the two materials aims to neutralize the positive charge of the chitosan as well as increase the hydrophilicity and mechanical properties of the membrane.…”

Section: Introductionmentioning

confidence: 99%

“…The OH-group located along the open chain of PVA made this material easy to modify by substituting the hydroxyl group with other groups according to particular purposes [7] in this case for hemodialysis membranes. The crosslinking reaction of PVA with citric acid is done in order to incorporate the reactive -COOH groups of citric acid to the backbone chain of PVA.…”

Section: Introductionmentioning

confidence: 99%

THE INFLUENCE OF PVA.cl.CITRIC ACID/CHITOSAN MEMBRANE HYDROPHICILITY ON THE TRANSPORT OF CREATININE AND UREA

Lusiana¹,

Siswanta²,

Mudasir³

et al. 2013

Indones. J. Chem.

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The influence of cross-linking and membrane hydrophilicity on the transport rate had been studied using a membrane prepared from a mixture of chitosan/PVA cross-linked citric acid (PVA.cl.CA) for creatinine and urea transport. The optimum mole ratio of PVA:citric acid as well as the best composition of chitosan:PVA.cl.CA were determined using creatinine transport study. Using the optimum compositions, further study was done using different thickness of the membrane in transporting creatinine, urea and a mixture of 3 species (creatinine, urea and vitamin B 12

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Hemodialysis membranes prepared from poly(vinyl alcohol): Effects of the preparation conditions on the morphology and performance

Cited by 24 publications

References 24 publications

Permeability of Urea in N-Carboxymethyl Chitosan-Poly (Vynilalcohol) Blend Membranes for Hemodialysis

Permeability of Urea in N-Carboxymethyl Chitosan-Poly (Vynilalcohol) Blend Membranes for Hemodialysis

Hydrogel films and coatings by swelling-induced gelation

THE INFLUENCE OF PVA.cl.CITRIC ACID/CHITOSAN MEMBRANE HYDROPHICILITY ON THE TRANSPORT OF CREATININE AND UREA

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