Heparin-like surface modification of polyethersulfone membrane and its biocompatibility

Grafting of zwitterion from polysulfone membrane via surface-initiated ATRP with enhanced antifouling property and biocompatibility

“…Furthermore, to improve antifouling property and biocompatibility of membranes, several polymers were used for surface modification over the past two decades, such as heparin [15][16][17][18][19], heparin-like polymers [20][21][22][23][24], PEG [6,8,9,25,26], phospholipid polymers [3][4][5][27][28][29] and zwitterionic polymers [7,[30][31][32][33][34][35][36][37][38][39][40], and so on. It was reported that the polymers with zwitterionic structures (sulfobetaine and carboxybetaine) could maintain normal conformation of biomacromolecules and improve biocompatibility [30,34].…”

Facile chemical modification of polysulfone membrane with improved hydrophilicity and blood compatibility

“…The APTTs for the PSf and PSf-Cl membranes were about 48.2 s. After -OH groups was introduced onto the membrane surface, the APTT was slightly increased to 51.1 s. Surprisingly, the APTTs for the -COOH and -SO 3 H grafted membranes were about 61.3 and 75.1 s, respectively. The improved anticoagulant property may be due to the combination of Ca 2 þ in the blood plasma [12,13]. As shown in Fig.…”

Overview of PES biocompatible/hemodialysis membranes: PES–blood interactions and modification techniques

“…The successful reduction might be attributed to the increased hydrophilicity and anionic character of additive. Tang et al [29] used the anionic character contributed by poly(acrylonitrile-co-vinylpyrrolidone-co-acrylic acid (P(AN-co-VP-co-AA)) to decrease the platelet adsorption from 142 to 30 (1 × 10 4 cells/cm 2 ) with SPES and PES membranes respectively. Liu et al [30] blended PES membrane with poly(vinylpyrrolidone-coacrylic acid) (P(VP-co-AA)) with grafted BSA and Nie et al [31] used poly(styrene-co-acrylic acid)-b-poly(vinyl pyrrolidone)-bpoly(styrene-co-acrylic acid) (P(St-co-AA)-b-PVP-b-P(St-co-AA)) additive to minimize the platelet adsorption as illustrated in Fig.…”

“…Complement activations are the inflammatory responses, started by localized inflammatory mediator which prompt the host defense system and could be quantified by the production of anaphylatoxins C5a, C4a and C3a [33]. The constituents of a complement system consist of a number of plasma proteins that act either as binding proteins or enzymes.…”