Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic diets

Abstract

These results support the concept that both hyperinsulinemia and a low-fat diet increase DNL, and that DNL contributes to hypertriglyceridemia.

Genome-wide transcriptome expression in the liver of a mouse model of high carbohydrate diet-induced liver steatosis and its significance for the disease

“…2) were identified whose expression was changed in the livers of HCD-fed animals. These genes include the ones that encode the enzymes, approximately 20, involved in glucose and fructose metabolism and their conversion to fat [10,12,15] ( Table 3 and Table I of supplementary material, and Fig. 4).…”

“…Human clinical investigations have demonstrated that a diet low in fat and rich in carbohydrates (closely resembling the HCD used in our mouse study), even when administered for short periods of time, for example, 5 or 25 days, can lead to occurrence of uncomplicated fatty liver [12][13][14][15]. Thus, this mouse model is a highly relevant means of investigating mechanisms of hepatic steatosis.…”

Concept of fat balance in human obesity revisited with particular reference to de novo lipogenesis

“…31 The major confounding factor seems to be the degree of insulin resistance. 32 The key issue is whether or not obesity (at least some form of obesity) may be associated to an increase in DNL through the regular consumption of high CHO meals in state of positive energy balance.…”

A high-carbohydrate diet enhances the adverse effect of the S2 allele of APOC3 SstI polymorphism on the TG/HDL-C ratio only in young Chinese females

“…Previous studies (31) have indicated that serum lipids could reach a new steady state after 5 days of dietary intervention. Therefore, a regime of 7 days of washout control diet followed by 6 days of high-CHO intervention diet was adopted in this study.…”