Hepatoprotcetive Effects of Oyster (Crassostrea gigas) Extract in a Rat Model of Alcohol-Induced Oxidative Stress

Osaki, Kenji; Arakawa, Teruaki; Kim, Bumsik; 이민재,; 정창식,; 강남길,

doi:10.3746/jkfn.2016.45.6.805

Cited by 6 publications

(7 citation statements)

References 21 publications

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“…It was necessary to first test the effect of oyster extract or lyophilized oyster powder untreated with hydrolase to determine whether it has similar activity as OH. Although many reports have demonstrated the hepatoprotective effect of oyster extract, the method of making oyster extract differs between reports, and some comments have been omitted [ 48 , 49 , 50 ]. So, we were unable to accurately determine the effect of oyster extract.…”

Section: Discussionmentioning

confidence: 99%

Dipeptide YA is Responsible for the Positive Effect of Oyster Hydrolysates on Alcohol Metabolism in Single Ethanol Binge Rodent Models

et al. 2020

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Accumulative alcohol hangovers cause liver damage through oxidative and inflammatory stress. Numerous antioxidant and anti-inflammatory reagents have been developed to reduce alcohol hangovers, but these reagents are still insignificant and have limitations in that they can cause liver toxicity. Oyster hydrolysate (OH), another reagent that has antioxidant and anti-inflammatory activity, is a product extracted through an enzymatic hydrolysis process from oysters (Crassostrea gigas), which can be easily eaten in meals. This study was aimed at determining the effects of OH on alcohol metabolism, using a single high dose of ethanol (EtOH) administered to rodents, by monitoring alcohol metabolic enzymes, oxidative stress signals, and inflammatory mediators. The effect of tyrosine-alanine (YA) peptide, a main component of OH, on EtOH metabolism was also identified. In vitro experiments showed that OH pretreatment inhibited EtOH-induced cell death, oxidative stress, and inflammation in liver cells and macrophages. In vivo experiments showed that OH and YA pre-administration increased alcohol dehydrogenase, aldehyde dehydrogenase, and catalase activity in EtOH binge treatment. In addition, OH pre-administration alleviated CYP2E1 activity, ROS production, apoptotic signals, and inflammatory mediators in liver tissues. These results showed that OH and YA enhanced EtOH metabolism and had a protective effect against acute alcohol liver damage. Our findings offer new insights into a single high dose of EtOH drinking and suggest that OH and YA could be used as potential marine functional foods to prevent acute alcohol-induced liver damage.

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Section: Discussionmentioning

confidence: 99%

Dipeptide YA is Responsible for the Positive Effect of Oyster Hydrolysates on Alcohol Metabolism in Single Ethanol Binge Rodent Models

et al. 2020

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“…(2015), Osaki et al . (2016) and Lee et al . (2021) demonstrated that the C. gigas components exerted hepatoprotective effects.…”

Section: Bioactivities Of Bioactive Compounds From C Gigasmentioning

confidence: 96%

“…The hydrolysate of C. gigas is reported to exert hepatoprotective effects (Osaki et al ., 2016; Lee et al ., 2021). Osaki et al .…”

Section: Bioactivities Of Bioactive Compounds From C Gigasmentioning

confidence: 99%

“…The hydrolysate of C. gigas is reported to exert hepatoprotective effects (Osaki et al, 2016;Lee et al, 2021). Osaki et al (2016) prepared C. gigas hydrolysate using water extraction and examined its hepatoprotective effect using ethanol-induced liver injury Wistar rat model by measuring the AST, ALT, MDA and CYP2E1 levels.…”

Section: Hepatoprotective Effect Of C Gigas In Vitro As Well As In Cl...mentioning

confidence: 99%

“…Several studies have reported the bioactive compounds of C. gigas , such as peptides (Je et al ., 2005; Han et al ., 2008; Liu et al ., 2008; Wang et al ., 2010; Hwang et al ., 2012; Cheong et al ., 2013; Seo et al ., 2013a, 2013b; Nam et al ., 2015; Hwang et al ., 2019), polysaccharides (Qian et al ., 2008; Shi et al ., 2015; Wang et al ., 2016; Zhang et al ., 2016; Cheong et al ., 2017; Hu et al ., 2017; Getachew et al ., 2019), oligosaccharides (Wu & Huang, 2017), polyphenols (Watanabe et al . 2012a) and lipids (Kim et al ., 2010), as well as those of C. gigas hydrolysate (Kim et al ., 2015; Osaki et al ., 2016; Lee et al ., 2018, 2021), mRNA (Sun et al . 2014), and powder (Bac et al ., 1998; Tanaka et al ., 2003).…”

Section: Introductionmentioning

confidence: 99%

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Nutritional value and potential bioactivities of Pacific oyster (Crassostrea gigas)

Negara

Mohibbullah

Sohn

et al. 2022

Int J of Food Sci Tech

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Globally, Pacific oysters (Crassostrea gigas) have a high market demand owing to their increased nutritional value. Crassostrea gigas can be a dietary source to meet the daily nutritional needs. Several studies have evaluated the nutritional value and bioactivity of C. gigas. However, a review of studies examining the nutritional value and bioactivity of C. gigas has not been previously performed. This study aimed to review the studies evaluating the nutritional value and bioactivities of C. gigas components using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The online databases Web of Science, ScienceDirect, MEDLINE and PubMed were searched to retrieve published studies on the nutritional value and bioactivity of C. gigas. Among the 37 studies obtained after filtering, the highest number of studies evaluated other bioactivities of C. gigas, followed by studies evaluating the antioxidant activity. This review examined the C. gigas components, including protein, moisture, glycogen, minerals, essential amino acids and fatty acids, which exerted beneficial effects on human health. Environmental conditions and cultivation techniques influenced the nutritional contents of C. gigas. The bioactive components of C. gigas exhibited antimicrobial, antioxidant, anti-inflammatory, antitumor and anticancer, hepatoprotective, antihypertensive, hypoglycaemic, skin whitening, skin immunomodulatory, antiwrinkle, cholesterol-lowering, antiaudiogenic seizure and probiotic activities. In conclusion, C. gigas has a high nutritional value and comprises various bioactive components. Thus, C. gigas can be a source of bioactive components and a functional food. However, most studies evaluating the bioactivity of C. gigas were performed in vitro.

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In vivo protective effect against ethanol metabolism and liver injury of oyster (Crassostrea Gigas) extracts obtained via subcritical water processing

Lee

Saravana

et al. 2021

Food Sci Biotechnol

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Hepatoprotcetive Effects of Oyster (Crassostrea gigas) Extract in a Rat Model of Alcohol-Induced Oxidative Stress

Cited by 6 publications

References 21 publications

Dipeptide YA is Responsible for the Positive Effect of Oyster Hydrolysates on Alcohol Metabolism in Single Ethanol Binge Rodent Models

Dipeptide YA is Responsible for the Positive Effect of Oyster Hydrolysates on Alcohol Metabolism in Single Ethanol Binge Rodent Models

Nutritional value and potential bioactivities of Pacific oyster (Crassostrea gigas)

In vivo protective effect against ethanol metabolism and liver injury of oyster (Crassostrea Gigas) extracts obtained via subcritical water processing

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