Hepatoprotective Effects and Antioxidant Potential of Polyherbal Formulation Against CCl4- Induced Hepatic Injury in Albino Rats

Yogi, Bhumika; Mishra, Ashutosh

doi:10.2174/2215083802666160620131553

Cited by 3 publications

(5 citation statements)

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“…1g). Morphological findings in all groups of this study were consistent with observations of serum enzymes such as SGPT, SGOT, ALP, cholesterol, and tuberculosis values as reported previously [27].…”

Section: Yogi and Mishrasupporting

confidence: 92%

“…. Phytoconstituents such as phenolic compounds and tannins were reported for their hepatoprotective effects [27] and these two were present in alcoholic and aqueous extracts. These active principles may be accounted for hepatoprotective effect.…”

Section: Resultsmentioning

confidence: 99%

“…Herbal ingredients were powdered separately and stored. Polyherbal preparation was made by mixing the three ingredients in equal ratio (w/w) and homogenizing in aqueous methanol (30:70) with the help of a pestle and mortar [27]. Polyherbal formulation and crude extracts were macerated with aqueous methanol (30:70) for 7 days in airtight vessels with occasional shaking at room temperature.…”

Section: Preparation Of Crude Extracts and Polyherbal Formulationmentioning

confidence: 99%

“…The acute toxicity studies for the formulation and extracts of G. sylvestre, C. procera, and L. inermis were performed earlier using OECD 423 guideline [27].…”

Section: Acute Toxicity Studiesmentioning

confidence: 99%

“…Biochemical parameters such as serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), serum alkaline phosphatase (ALP), and total bilirubin, cholesterol were analyzed and reported previously [27].…”

Section: Estimation Of Biochemical Markersmentioning

confidence: 99%

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Hepatoprotective Effects of Polyherbal Formulation Against Carbon Tetrachloride-Induced Hepatic Injury in Albino Rats: A Toxicity Screening Approach

Yogi¹,

Mishra²

2016

Asian J Pharm Clin Res

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Objective: To investigate the hepatoprotective activity of aqueous methanolic extract of polyherbal formulation and individual extracts of Calotropis procera, Gymnema sylvestre, and Lawsonia inermis leaves. Methods:The hepatoprotective activity of the formulation and extracts were assessed on the basis of histopathological changes in liver of carbon tetrachloride-induced hepatotoxic rats. Results:The result of present studies strongly indicates that the hepatoprotective property of polyherbal formulation as evidenced by less damaged hepatocytes cells. Conclusion:Polyherbal formulation revealed excellent hepatoprotective profile as compared to individual plants due to synergistic effect produced by different phytochemicals present in the formulation.

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Section: Yogi and Mishrasupporting

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Section: Preparation Of Crude Extracts and Polyherbal Formulationmentioning

confidence: 99%

“…The acute toxicity studies for the formulation and extracts of G. sylvestre, C. procera, and L. inermis were performed earlier using OECD 423 guideline [27].…”

Section: Acute Toxicity Studiesmentioning

confidence: 99%

Section: Estimation Of Biochemical Markersmentioning

confidence: 99%

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Hepatoprotective Effects of Polyherbal Formulation Against Carbon Tetrachloride-Induced Hepatic Injury in Albino Rats: A Toxicity Screening Approach

Yogi¹,

Mishra²

2016

Asian J Pharm Clin Res

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Hepatoprotective and Curative Activities of Daphne Gnidium L. Aqueous Extract Against CCl4-Induced Liver Injury in Rats

Medila

Ikram

Adaika

2021

CBC

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Background:: Liver is one of the largest organs of the human body and the main site for intense metabolism and excretion. Liver injury or dysfunction is recognized as a serious worldwide health problem. Daphne gnidium L., medicinal plant widely distributed in Algeria and used by populations in traditional medicine in the treatment of hepatitis and other diseases. Objective:: Protective and curative effects of aqueous extract of Daphne gnidium L. leaves were investigated against carbon tetrachloride (CCl4) induced hepatic damage in rats (Wistar Albino). Method:: This study was conducted on 32 Albino rats, which were divided into four groups; the first served as control. Group II animals were treated intraperitoneally with CCl4 solution (3ml/kg). Group III animals were treated intraperitoneally with CCl4 solutions (3ml/kg) in the first day, and given aqueous Daphne extract orally at a dose level of (300 mg/kg) daily for 7 days (curative activity test). Animals of group IV were orally administered aqueous Daphne extract at a dose level of (300 mg/kg) daily, and on the seventh day treated intraperitoneally with CCl4 solution (3ml/kg) 3 hours after the latest extract administration (preventive activity test). Results:: Our results show that CCl4 significantly increases the relative liver weight, serum values of ALT, AST, ALP, GGT, and Total bilirubin, as well as the hepatic rate of oxidative stress parameters; MDA, CAT activities, and significantly decreases hepatic GSH levels compared to the control group. These results were confirmed by liver lesions observed in histological analyses. Pre-treatment and curative treatment of dose 300 mg / kg of aqueous Daphne gnidium L. extract significantly reduced relative weight, serum levels of ALT, AST, ALP, GGT and Total bilirubin liver rate, CAT activity and increases GSH level. In addition, normal liver architecture has been restored. Conclusion:: The present study demonstrates the hepatoprotective and curative effects of aqueous extract Daphne gnidium leaves against CCl4-induced liver injury in rats by improving the antioxidant status in tissues (liver) and ameliorating the harmful effects induced by CCl4.

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Hepatoprotective activities of polyherbal formulations: A systematic review

Aladejana,

Aladejana

2023

Journal of Medicinal Plants for Economic Development

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Background: Liver diseases pose a substantial global public health challenge, encompassing conditions such as liver failure, hepatitis, cirrhosis and associated complications Safeguarding the liver becomes important as these conditions impact human health. Hepatoprotective agents play a pivotal role in mitigating liver damage caused by chemicals, drugs and toxins. Polyherbal formulations, combining botanical components from traditional medicine, offer a promising approach to addressing liver disorders. Their popularity arises from a multi-targeted strategy in treating complex diseases, marking a shift in focus toward these formulations.Aim: The study aimed to conduct a thorough review of the existing literature on the hepatoprotective activity of polyherbal formulations and provide a comprehensive overview of their mechanisms of action. This review provides the overview of the use of polyherbal formulations in the management of liver disease.Method: A systematic search of electronic databases, including : Scopus, Academia, Elsevier, Science Direct, Wiley, BioMed Central, PubMed, and Google Scholar, was conducted using a combination of keywords such as ‘polyherbal formulations’, ‘hepatoprotective’ and ‘liver diseases’. Studies published between January 2010 and April 2023 were included in the review.Results: A total of 61 articles were reviewed, and the studies showed that polyherbal formulations possess significant hepatoprotective activity against various hepatotoxic agents. The mechanisms of action of these formulations include antioxidant, antiinflammatory, antifibrotic and antiapoptotic effects. Additionally, some polyherbal formulations were found to stimulate liver regeneration, enhance bile secretion and promote detoxification processes.Conclusion: Polyherbal formulations have shown promising hepatoprotective activity, and their multitargeted approach to treating complex diseases makes them a potential alternative to conventional medicines. However, identifying the active compounds responsible for the hepatoprotective effects of these formulations and their pharmacokinetics and pharmacodynamics could provide insights into the development of new and effective drugs for liver disorders.Contribution: This article contributes to the growing body of literature on the potential of polyherbal formulations as hepatoprotective agents.

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Hepatoprotective Effects and Antioxidant Potential of Polyherbal Formulation Against CCl4- Induced Hepatic Injury in Albino Rats

Cited by 3 publications

References 0 publications

Hepatoprotective Effects of Polyherbal Formulation Against Carbon Tetrachloride-Induced Hepatic Injury in Albino Rats: A Toxicity Screening Approach

Hepatoprotective Effects of Polyherbal Formulation Against Carbon Tetrachloride-Induced Hepatic Injury in Albino Rats: A Toxicity Screening Approach

Hepatoprotective and Curative Activities of Daphne Gnidium L. Aqueous Extract Against CCl4-Induced Liver Injury in Rats

Hepatoprotective activities of polyherbal formulations: A systematic review

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